Lorenzo Spagnuolo

Dutch Research Council — Netherlands

Medicine · Health Sciences

11h-index719citations21works0.02yr avg
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Research Topics

Cancer Immunotherapy and Biomarkers(7), Immunotherapy and Immune Responses(6), Immune Cell Function and Interaction(6), Immune cells in cancer(5), Immune Response and Inflammation(4)

Publications21 total

Abstract 243: Organoid co-cultures with allogenic T cells to assess toxicity and efficacy of bispecific antibodies
Cancer Research·2024
Abstract 2696: Tumor organoid and immune cells co-cultures to study myeloid cells-targeting immunotherapy
Cancer Research·2024
Neoadjuvant immune checkpoint blockade triggers persistent and systemic T <sub>reg</sub> activation which blunts therapeutic efficacy against metastatic spread of breast tumors
OncoImmunology·2023· 55 citedOpen Access
IL-5-producing CD4+ T cells and eosinophils cooperate to enhance response to immune checkpoint blockade in breast cancer
Cancer Cell·2022· 192 citedOpen Access
HMGB1 promotes CXCL12‐dependent egress of murine B cells from Peyer's patches in homeostasis
European Journal of Immunology·2021· 12 citedOpen Access
Author response for "HMGB1 promotes CXCL12‐dependent egress of murine B cells from Peyer's patches in homeostasis"
2021Open Access
LBA10 Critical role of eosinophils during response to immune checkpoint blockade in breast cancer and other cancer types
Annals of Oncology·2020· 13 cited
Amphiphilic nanoparticle delivery enhances the anticancer efficacy of a TLR7 ligand via local immune activation
Biomaterials·2018· 58 citedOpen Access
Immune regulation of metastasis: mechanistic insights and therapeutic opportunities
Disease Models & Mechanisms·2018· 147 citedOpen Access
Activation of M2 muscarinic acetylcholine receptors by orthosteric and dualsteric agonists in glioblastoma cancer stem cells: effects on cell proliferation and drug resistance
2018
PO-365 Dissecting the synergistic effect of chemotherapy and immunotherapy on anti-tumoral T cell functions in breast cancer
ESMO Open·2018Open Access
NAB2 is a novel immune stimulator of MDA-5 that promotes a strong type I interferon response
Oncotarget·2017· 6 citedOpen Access
Arginase inhibition suppresses lung metastasis in the 4T1 breast cancer model independently of the immunomodulatory and anti-metastatic effects of VEGFR-2 blockade
OncoImmunology·2017· 56 citedOpen Access
Reprogramming of TLR7 signaling enhances antitumor NK and cytotoxic T cell responses
OncoImmunology·2016· 35 citedOpen Access
TLR7-based cancer immunotherapy decreases intratumoral myeloid-derived suppressor cells and blocks their immunosuppressive function
OncoImmunology·2016· 79 citedOpen Access
Selective agonists for M2 muscarinic acetylcholine receptors inhibit cell proliferation and survival in human glioblastoma cells: possible effects on drug resistance
2016
A Reappraisal of the Diagnostic and Therapeutic Management of Uncommon Histologies of Primary Ocular Adnexal Lymphoma
The Oncologist·2013· 42 citedOpen Access
CDC25A Protein Stability Represents a Previously Unrecognized Target of HER2 Signaling in Human Breast Cancer: Implication for a Potential Clinical Relevance in Trastuzumab Treatment
Neoplasia·2013· 19 citedOpen Access
Gains of <i><scp>CCND</scp>3</i> gene in ocular adnexal <scp>MALT</scp> lymphomas: an integrated analysis
British Journal of Haematology·2012· 5 citedOpen Access
[A case of simultaneous intra- and extra-uterine pregnancy. Diagnostic and therapeutic considerations].
PubMed·1989
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Frequent Co-authors

Carole Bourquin(7), Olga Blomberg(5), Karin E. de Visser(5), Thibaud Spinetti(5), Inès Mottas(5), Kelly Kersten(4), C. Hotz(4), Anne Oberson(4), Hannah Garner(3), Olga I. Isaeva(3), Noor A. M. Bakker(3), Cheei‐Sing Hau(3), Kim Vrijland(3), Kevin Kos(3), Marleen Kok(3), Claudio Doglioni(3), Viola Puddinu(3), Leonie Voorwerk(2), Ewald van Dyk(2), Myriam Chalabi(2)