Jakub Rohlena

Czech Academy of Sciences, Institute of Biotechnology — Czech Republic

Biochemistry, Genetics and Molecular Biology · Life Sciences

35h-index5.3kcitations112works2.52yr avg
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Research Topics

Mitochondrial Function and Pathology(47), Cancer, Hypoxia, and Metabolism(44), ATP Synthase and ATPases Research(22), RNA modifications and cancer(11), Metabolism and Genetic Disorders(9)

Publications107 total

Macrophage-secreted Pyrimidine Metabolites Confer Chemotherapy Resistance in Acute Myeloid Leukemia (AML)
2025· 1 citedOpen Access
Role of ANT2 in mitochondrial function and cancer cell survival: a target for therapeutic intervention
Cell Death Discovery·2025· 2 citedOpen Access
Distinct transcriptional changes in hematopoietic progenitor subsets on LPS-induced emergency granulopoiesis
Experimental Hematology·2025· 3 citedOpen Access
Abstract 6381: SAMHD1high macrophages drive resistance to cytarabine in acute myeloid leukemia (AML) by pyrimidine metabolite deoxycytidine (dC)
Cancer Research·2025
HSCs and Tregs cooperate to preserve extramedullary hematopoiesis under chronic inflammation
2025
The adaptor protein Miro1 modulates horizontal transfer of mitochondria in mouse melanoma models
Cell Reports·2025· 11 citedOpen Access
Abstract A018: Endothelial pyrimidine synthesis deficiency promotes tumor growth
Cancer Research·2024
The adaptor protein Miro1 modulates horizontal transfer of mitochondria in cancer
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease·2024
Alternative pahtway of asparate synthesis sustains tumor growth
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease·2024
Miro1 role in intra- and inter-cellular mitochondrial movement in tumour microenvironment
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease·2024
Aspartate in tumor microenvironment and beyond: Metabolic interactions and therapeutic perspectives
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease·2024· 12 cited
3113 – CD53 AND MHCII EXPRESSION DEFINE A UNIQUE HSC PRESENT IN EXTRAMEDULLARY HEMATOPOIETIC SITES UNDER CHRONIC INFLAMMATION
Experimental Hematology·2024
3188 – WNT LIGAND SECRETION REGULATES EMERGENCY GRANULOPOEISIS BY INDUCING MYELOID DIFFERENTIATION
Experimental Hematology·2024
Mitochondrial <scp>HER</scp>2 stimulates respiration and promotes tumorigenicity
European Journal of Clinical Investigation·2024· 6 citedOpen Access
Disordered-to-ordered transitions in assembly factors allow the complex II catalytic subunit to switch binding partners
Nature Communications·2024· 7 citedOpen Access
Disordered-to-ordered transitions in assembly factors allow the complex II catalytic subunit to switch binding partners
Figshare·2024Open Access
Role of Miro1 adaptor protein in mitochondrial mobility between cancer and stromal cells
BIO Web of Conferences·2024Open Access
Distinct Cellular, Transcriptional, and Mechanistic Properties Determine HSC Fate during Emergency Granulopoiesis
Blood·2023
Hematopoietic stem cells undergo a lymphoid to myeloid switch in early stages of emergency granulopoiesis
The EMBO Journal·2023· 14 citedOpen Access
MitoTam-01 Trial: Mitochondrial Targeting as Plausible Approach to Cancer Therapy. Comment on Yap et al. Complex I Inhibitor of Oxidative Phosphorylation in Advanced Solid Tumors and Acute Myeloid Leukemia: Phase I Trials. Nat. Med. 2023, 29, 115–126
Cancers·2023· 7 citedOpen Access
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Frequent Co-authors

Jiřı́ Neužil(39), Lan‐Feng Dong(24), Kateřina Rohlenová(11), Renata Zobalová(11), Katarína Kľučková(10), Jaroslav Truksa(10), Pavel Hozák(8), Soňa Hubáčková(8), Jan Štursa(8), Ayenachew Bezawork‐Geleta(7), Jacob Goodwin(7), Michael V. Berridge(6), Štěpána Boukalová(6), Zuzana Nahácka(6), Stephen J. Ralph(6), Berwini Endaya(5), Martina Bajzíková(5), Hans Pannekoek(5), Silvia Magalhaes Novais(5), Jaromíra Kovářová(4)