Gabriele M. König

University of North Carolina at Chapel Hill — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

63h-index13.4kcitations363works5.32yr avg
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Research Topics

Marine Sponges and Natural Products(127), Microbial Natural Products and Biosynthesis(126), Receptor Mechanisms and Signaling(35), Protein Kinase Regulation and GTPase Signaling(26), Synthetic Organic Chemistry Methods(26)

Publications363 total

Psychedelic compounds directly excite 5-HT2A layer V medial prefrontal cortex neurons through 5-HT2A Gq activation
UNC Libraries·2025Open Access
Psychedelic compounds directly excite 5-HT2A layer V medial prefrontal cortex neurons through 5-HT2A Gq activation
Translational Psychiatry·2025· 7 citedOpen Access
Cyclic peptide inhibitors function as molecular glues to stabilize Gq/11 heterotrimers
Proceedings of the National Academy of Sciences·2025· 2 citedOpen Access
Silencing Gq Proteins Prevents and Reverses Pulmonary Hypertension
American Journal of Respiratory and Critical Care Medicine·2025
Glue-Tiful Inhibitors: Cyclic Depsipeptides Enhance Protein-Protein Interaction within the Subunits of Heterotrimeric Gq/11 Proteins (Abstract ID: 164994)
Journal of Pharmacology and Experimental Therapeutics·2025Open Access
A molecular mechanism to diversify Ca2+ signaling downstream of Gs protein-coupled receptors
Nature Communications·2024· 21 citedOpen Access
Pharmacological Gq inhibition induces strong pulmonary vasorelaxation and reverses pulmonary hypertension
EMBO Molecular Medicine·2024· 3 citedOpen Access
GRK specificity and Gβγ dependency determines the potential of a GPCR for arrestin-biased agonism
Communications Biology·2024· 17 citedOpen Access
Structural response of G protein binding to the cyclodepsipeptide inhibitor FR900359 probed by NMR spectroscopy
Chemical Science·2024· 2 citedOpen Access
Biosynthesis of the corallorazines, a widespread class of antibiotic cyclic lipodipeptides
RSC Chemical Biology·2024· 1 citedOpen Access
Cyclic peptide inhibitors stabilize Gq/11 heterotrimers
2023· 4 citedOpen Access
The Bacterial Gq Signal Transduction Inhibitor FR900359 Impairs Soil-Associated Nematodes
Journal of Chemical Ecology·2023· 4 citedOpen Access
Adenylation Domain-Guided Recruitment of <i>Trans-</i>Acting Nonheme Monooxygenases in Nonribosomal Peptide Biosynthesis
ACS Chemical Biology·2023· 6 cited
The Bacterial Gq Signal Transduction Inhibitor Fr900359 Impairs Soil-associated and Plant Pathogenic Nematodes
Research Square (Research Square)·2023Open Access
Glucose-stimulated insulin secretion depends on FFA1 and Gq in neonatal mouse islets
Diabetologia·2023· 5 citedOpen Access
Structure-affinity and structure-residence time relationships of macrocyclic Gαq protein inhibitors
iScience·2023· 10 citedOpen Access
Is a Modified Actin the Key to Toxin Resistance in the Nudibranch Chromodoris? A Biochemical and Molecular Approach
Diversity·2023· 3 citedOpen Access
Author Correction: Selective optogenetic control of Gq signaling using human Neuropsin
Nature Communications·2023Open Access
Pharmacokinetics and Pharmacodynamics (PK/PD) of Corallopyronin A against Methicillin-Resistant Staphylococcus aureus
Pharmaceutics·2022· 16 citedOpen Access
Imaging of Gαq Proteins in Mouse and Human Organs and Tissues
Pharmaceutics·2022· 1 citedOpen Access
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Frequent Co-authors

Anthony D. Wright(19), Stefan Kehraus(16), Evi Kostenis(9), Ronald Kaminsky(5), Anja Krick(5), Till F. Schäberle(5), Nicole Merten(4), Asuka Inoue(4), Raphael Reher(4), Cindy K. Angerhofer(4), Katharina Simon(3), Ulrike Rick(3), Junken Aoki(3), Jesús Gomeza(3), Ramona Schrage(3), Ahmed Abdel‐Lateff(3), Otto Sticher(3), Ulrich Höller(3), Alexander Pfeifer(3), Harald Gross(3)