Christopher J. Guerriero

University of Pittsburgh — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

18h-index1.6kcitations46works1.72yr avg
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Research Topics

Endoplasmic Reticulum Stress and Disease(22), Cellular transport and secretion(12), Autophagy in Disease and Therapy(11), Heat shock proteins research(8), Pancreatic function and diabetes(6)

Publications46 total

Data for: Identification of polycystin 2 missense mutants targeted for endoplasmic reticulum-associated degradation
University Library System, University of Pittsburgh·2026Open Access
Heterozygous ADAR mutant mice exhibit RNA sensing-dependent neuroinflammation and phenotypes associated with Aicardi-Goutières syndrome
iScience·2026Open Access
Regulated degradation of KCC2, a potassium-chloride co-transporter required for synaptic transmission and neurodevelopment
Channels·2025Open Access
<i>In vivo</i> manipulation of the protein homeostasis network in rhabdomyosarcoma
Oncotarget·2025· 2 citedOpen Access
Aicardi-Goutières Syndrome Associated <i>ADAR</i> G1007R mutation dominantly induces neuroinflammation in mouse brain
2025Open Access
Identification of polycystin 2 missense mutants targeted for endoplasmic reticulum-associated degradation
American Journal of Physiology-Cell Physiology·2024· 3 citedOpen Access
Investigating the Biogenesis and Degradation of Polycystin 2 Missense Mutants
Journal of the American Society of Nephrology·2024
Characterization of hyperactive mutations in the renal potassium channel ROMK uncovers unique effects on channel biogenesis and ion conductance
Molecular Biology of the Cell·2024· 2 citedOpen Access
The HERCulean task of recognizing, ubiquitinating, and shielding misfolded integral membrane proteins
The Journal of Cell Biology·2024Open Access
Loss of Grp170 results in catastrophic disruption of endoplasmic reticulum function
Molecular Biology of the Cell·2024· 10 citedOpen Access
Loss of Grp170 results in catastrophic disruption of endoplasmic reticulum functions
2023· 3 citedOpen Access
Lhs1 dependent ERAD is determined by transmembrane domain context
Biochemical Journal·2023· 5 citedOpen Access
A campaign targeting a conserved Hsp70 binding site uncovers how subcellular localization is linked to distinct biological activities
Cell chemical biology·2022· 12 citedOpen Access
Substrate ubiquitination retains misfolded membrane proteins in the endoplasmic reticulum for degradation
Cell Reports·2021· 13 citedOpen Access
Distinct classes of misfolded proteins differentially affect the growth of yeast compromised for proteasome function
FEBS Letters·2021· 6 citedOpen Access
Harmonizing Experimental Data with Modeling to Predict Membrane Protein Insertion in Yeast
Biophysical Journal·2019· 5 citedOpen Access
Abstract 4268: Protein folding pathway modulation upon Hsp70 inhibition in cancer cells
Cancer Research·2019
Abstract 4268: Protein folding pathway modulation upon Hsp70 inhibition in cancer cells
Molecular and Cellular Biology / Genetics·2019
Hsp104 facilitates the endoplasmic‐reticulum–associated degradation of disease‐associated and aggregation‐prone substrates
Protein Science·2019· 17 citedOpen Access
Chaperoning Endoplasmic Reticulum–Associated Degradation (ERAD) and Protein Conformational Diseases
Cold Spring Harbor Perspectives in Biology·2019· 142 citedOpen Access
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Frequent Co-authors

Jeffrey L. Brodsky(32), Ora A. Weisz(10), Amit J. Sabnis(7), Sara Sannino(6), Peter Wipf(5), Trever G. Bivona(5), Kelly M. Weixel(4), Kurt F. Weiberth(4), Gregory M. Preston(4), Teresa M. Buck(4), Mark T. Miedel(3), Youssef Rbaibi(3), Michael Grabe(3), Karl‐Richard Reutter(3), Andrew A. Augustine(3), Kunio Nakatsukasa(3), Paul A. Welling(3), Thomas R. Kleyman(3), Hannah E. Vorndran(3), Maria Sukhoplyasova(3)