Megan L. Peach

Frederick National Laboratory for Cancer Research — United States

Computer Science · Physical Sciences

21h-index1.6kcitations69works8.52yr avg
OpenAlex↗ORCID↗Google Scholar↗Lab page↗

Accepting Students?

No reports yet. Know if this professor is taking students?

Research Topics

Computational Drug Discovery Methods(20), Protein Kinase Regulation and GTPase Signaling(19), Microbial Natural Products and Biosynthesis(11), Ubiquitin and proteasome pathways(10), Protein Structure and Dynamics(8)

Publications69 total

Novel DAG‐Lactone‐Based Vav1 Inhibitors Show Anti‐proliferative Activity in Pancreatic Cancer Models
ChemMedChem·2025Open Access
KDM3B inhibitors disrupt the oncogenic activity of PAX3-FOXO1 in fusion-positive rhabdomyosarcoma
Nature Communications·2024· 17 citedOpen Access
Enigmazole Phosphomacrolides from the Marine Sponge <i>Cinachyrella enigmatica</i>
The Journal of Organic Chemistry·2023· 7 cited
KDM3B inhibitors disrupt PAX3-FOXO1 oncogenic activity in fusion positive rhabdomyosarcoma.
2022Open Access
Selective Recognition of Carbohydrate Antigens by Germline Antibodies Isolated from AID Knockout Mice
Journal of the American Chemical Society·2022· 6 citedOpen Access
Design, Synthesis, and Characterization of Novel <i>sn</i> -1 Heterocyclic DAG-Lactones as PKC Activators
Journal of Medicinal Chemistry·2021· 9 citedOpen Access
Antiangiogenic Activity and in Silico Cereblon Binding Analysis of Novel Thalidomide Analogs
Molecules·2020· 20 citedOpen Access
SAVI, in silico generation of billions of easily synthesizable compounds through expert-system type rules
Scientific Data·2020· 70 citedOpen Access
Design, Synthesis and Characterization of Novel sn-1 Heterocyclic DAGlactones as PKCe Activators
2020· 1 citedOpen Access
Design, Synthesis and Characterization of Novel sn-1 Heterocyclic DAGlactones as PKCe Activators
2020· 1 citedOpen Access
Synthetically Accessible Virtual Inventory (SAVI)
2020· 6 citedOpen Access
Synthetically Accessible Virtual Inventory (SAVI)
2020· 12 citedOpen Access
Synthetically Accessible Virtual Inventory (SAVI)
National Cancer Institute·2020· 11 citedOpen Access
Epigenetic re-wiring of breast cancer by pharmacological targeting of C-terminal binding protein
Cell Death and Disease·2019· 10 citedOpen Access
α-Arylidene Diacylglycerol-Lactones (DAG-Lactones) as Selective Ras Guanine-Releasing Protein 3 (RasGRP3) Ligands
Journal of Medicinal Chemistry·2018· 7 citedOpen Access
Chemoinformatics at the<scp>CADD</scp>Group of the National Cancer Institute
2018· 4 cited
Probing the <i>hras</i>-1<sup>Y</sup> i-motif with small molecules
MedChemComm·2018· 20 citedOpen Access
Therapeutic Antibodies to Ganglioside GD2 Evolved from Highly Selective Germline Antibodies
Cell Reports·2017· 20 citedOpen Access
Macrophilone A: Structure Elucidation, Total Synthesis, and Functional Evaluation of a Biologically Active Iminoquinone from the Marine Hydroid <i>Macrorhynchia philippina</i>
Organic Letters·2017· 21 citedOpen Access
Exploring the influence of indololactone structure on selectivity for binding to the C1 domains of PKCα, PKCε, and RasGRP
Bioorganic & Medicinal Chemistry·2017· 12 citedOpen Access
page 1 of 4Next →

Frequent Co-authors

Marc C. Nicklaus(28), Peter M. Blumberg(17), Nancy E. Lewin(15), Noémi Kedei(10), Víctor E. Márquez(10), Peter P. Roller(7), Dina M. Sigano(6), Alexey Zakharov(4), Markus Sitzmann(4), James B. McMahon(4), Kirk R. Gustafson(4), Nadya I. Tarasova(4), Gary E. Keck(4), Yongmei Pu(4), James A. Kelley(4), Manchao Zhang(4), Hongpeng Liu(4), Dajun Yang(4), Hitesh Patel(3), Philip N. Judson(3)