Tadhg P. Begley

Mitchell Institute — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

66h-index14.0kcitations305works1.22yr avg
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Research Topics

Metabolism and Genetic Disorders(79), Biochemical and Molecular Research(75), Enzyme Structure and Function(68), Biochemical Acid Research Studies(59), Alcoholism and Thiamine Deficiency(41)

Publications305 total

Vitamin B <sub>2</sub> Catabolism: Nature’s Route from Riboflavin to Acetoacetate and Pyruvate
ACS Central Science·2025· 2 citedOpen Access
Insights into the initial steps of the thiamin pyrimidine synthase (ThiC)-catalyzed reaction through EPR spectroscopic characterization of radical intermediates
Chemical Science·2025Open Access
Abstract 2036 Characterization of Riboflavin (Vitamin B2) Catabolism
Journal of Biological Chemistry·2025Open Access
Mec+ peptidase (Mycobacterium tuberculosis)
Handbook of Proteolytic Enzymes·2025
List of contributors
Handbook of Proteolytic Enzymes·2025
Phosphomethylpyrimidine Synthase (ThiC): Trapping of Five Intermediates Provides Mechanistic Insights on a Complex Radical Cascade Reaction in Thiamin Biosynthesis
ACS Central Science·2024· 9 citedOpen Access
Abstract 2295 Menaquinone Biosynthesis: Regioselectivity of Prenylation and Methylation in the final steps of aminofutalosine pathway
Journal of Biological Chemistry·2024Open Access
Abstract 2314 Phosphomethylpyrimidine synthase (ThiC): A “Radical Dance” in bacterial thiamin biosynthesis
Journal of Biological Chemistry·2024Open Access
Abstract 1585 Characterization of a bacterial vitamin B2 catabolic pathway
Journal of Biological Chemistry·2024Open Access
Alkylcysteine Sulfoxide C–S Monooxygenase Uses a Flavin-Dependent Pummerer Rearrangement
Journal of the American Chemical Society·2023· 13 citedOpen Access
Oxidative Dearomatization of PLP in Thiamin Pyrimidine Biosynthesis in <i>Candida albicans</i>
Journal of the American Chemical Society·2023· 3 citedOpen Access
Retraction notice to “Comparison of thiaminase activity in fish using the radiometric and 4-nitrothiophenol colorimetric methods” [J. Great Lakes Res. 36 (2010) 641–645]
Journal of Great Lakes Research·2022Open Access
Mechanistic Studies on the Single-Turnover Yeast Thiamin Pyrimidine Synthase: Characterization of the Inactive Enzyme
Journal of the American Chemical Society·2022· 2 cited
Cysteine Dealkylation in <i>Bacillus subtilis</i> by a Novel Flavin-Dependent Monooxygenase
Biochemistry·2022· 6 cited
Trapping and structural characterisation of a covalent intermediate in vitamin B<sub>6</sub> biosynthesis catalysed by the Pdx1 PLP synthase
RSC Chemical Biology·2021· 4 citedOpen Access
Radiosynthesis of 5-[18F]Fluoro-1,2,3-triazoles through Aqueous Iodine–[18F]Fluorine Exchange Reaction
Molecules·2021· 4 citedOpen Access
Menaquinone Biosynthesis: The Mechanism of 5,8-Dihydroxy-2-naphthoate Synthase (MqnD)
Biochemistry·2021· 2 cited
Menaquinone Biosynthesis: New Strategies to Trap Radical Intermediates in the MqnE-Catalyzed Reaction
Biochemistry·2021· 10 cited
Editorial Board
Journal of Biological Chemistry·2020Open Access
Editorial Board
Journal of Biological Chemistry·2020Open Access
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Frequent Co-authors

Cynthia Kinsland(14), S.E. Ealick(12), Fred W. McLafferty(11), Pieter C. Dorrestein(7), Sean V. Taylor(5), Erick Strauss(4), Ying Ge(3), Joo-Heon Park(3), Hsiu‐Ju Chiu(3), Keri L. Colabroy(3), Andrei L. Osterman(3), P. G. N. Nayar(3), Yang Zhang(3), Kristin E. Burns(3), Jun Xi(2), Oleg V. Kurnasov(2), Clifton E. Barry(2), C.R. Simmons(2), P. Andrew Karplus(2), Martha H. Stipanuk(2)