Amanda M. DiNofia

Children's Hospital of Philadelphia — United States

Medicine · Health Sciences

21h-index1.8kcitations97works5.52yr avg
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Research Topics

Acute Lymphoblastic Leukemia research(58), CAR-T cell therapy research(50), Virus-based gene therapy research(9), Neuroblastoma Research and Treatments(7), Adolescent and Pediatric Healthcare(7)

Publications97 total

CD19 CAR T-cell outcomes in relapsed/refractory extramedullary B-ALL: a multi-site, retrospective cohort review
Blood Advances·2026Open Access
CCR4 expression defines a targetable subset of T-cell acute lymphoblastic leukemia
Blood Advances·2026Open Access
CD19 CAR T-cell Therapy in Infant B-ALL: Durable Remissions, Relapse Patterns, and Molecular Correlates
Transplantation and Cellular Therapy·2026
Next Generation Sequencing Minimal Residual Disease in Pediatric B-ALL after CD19 and/or CD22 CAR T-cell Therapy: Depth and Kinetics of Response Predict Relapse Risk.
Transplantation and Cellular Therapy·2026
High Rates of Clinically Significant Late Infections and Recurrent Sinopulmonary Disease in Long-Term Survivors after CD19 CAR T-cell Therapy for Pediatric B-ALL
Transplantation and Cellular Therapy·2026
Hematopoietic cell transplantation after CD19-directed CAR T-cell therapy for remission consolidation or relapse treatment in pediatric acute lymphoblastic leukemia
Haematologica·2025Open Access
Humanized CD19 chimeric antigen receptor (CAR) T-cell therapy for high-risk and post-CAR relapse of B-cell acute lymphoblastic leukemia
Blood·2025
CD19 CAR T cell therapy is an effective strategy for first CNS relapse in pediatric b ALL
Blood·2025Open Access
CD123-directed chimeric antigen receptor T-cell (CART123) therapy for relapsed/refractory pediatric acute myeloid leukemia
Blood·2025
Financial toxicity and association with treatment outcomes during pediatric CAR T therapy.
Journal of Clinical Oncology·2025
CD22-targeted chimeric antigen receptor-modified T cells for children and adults with relapse of B-cell acute lymphoblastic leukemia after CD19-directed immunotherapy
Journal for ImmunoTherapy of Cancer·2025· 11 citedOpen Access
Clinical Factors Associated with Prolonged Cytopenias in Children and Young Adults Treated with CD19-Directed CAR T Cells (CAR19) for Acute Lymphoblastic Leukemia
Transplantation and Cellular Therapy·2025
Long-term safety of lentiviral or gammaretroviral gene-modified T cell therapies
Nature Medicine·2025· 58 cited
Therapies and outcomes following extramedullary relapse of pediatric and young adult ALL after CD19 CAR T-cell therapy
Blood Advances·2024· 4 citedOpen Access
Clinical Factors Associated with Prolonged Cytopenias after CD19 Chimeric Antigen Receptor T-Cell Therapy for Pediatric B-Cell Acute Lymphoblastic Leukemia
Blood·2024· 1 cited
Preinfusion Risk Factors for the Development of Severe Immune Effector Cell Associated Neurotoxicity Syndrome Following Chimeric Antigen Receptor T-Cell Infusion in Pediatric Patients
Blood·2024· 1 cited
In Vivo Persistence and Function of CAR19 T-Cell Products for Pediatric B-Cell Acute Lymphoblastic Leukemia Are Impacted By Media, Cytokine Supplementation and Metabolite Bioavailability during Ex Vivo Manufacturing
Blood·2024· 1 citedOpen Access
Cost-Effective Manufacture and Promising Initial Efficacy of huCART19 Cells Manufactured Using the Clinimacs Prodigy Platform
Blood·2024· 2 citedOpen Access
Abstract B051: Marrow and peripheral blood cytokine architecture differences between pediatric patients receiving CD19- and CD22-directed CART
Cancer Research·2024
Quadriparesis and paraparesis following chimeric antigen receptor T-cell therapy in children and adolescents
Blood·2024· 15 citedOpen Access
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Frequent Co-authors

Stephan A. Grupp(41), Shannon L. Maude(35), Regina M. Myers(33), Yimei Li(26), Richard Aplenc(25), Allison Barz Leahy(23), Susan R. Rheingold(21), Colleen Callahan(19), Lisa Wray(18), Carl H. June(18), Diane Baniewicz(17), David T. Teachey(15), Caroline Diorio(12), David M. Barrett(11), Vanessa Gonzalez(11), Alix E. Seif(10), Simon F. Lacey(9), Bruce L. Levine(9), Haley Newman(9), Hongyan Liu(9)