Adele K. Addington

Virginia Tech — United States

Medicine · Health Sciences

9h-index963citations23works0.32yr avg
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Research Topics

Adipose Tissue and Metabolism(8), Muscle Physiology and Disorders(4), Muscle metabolism and nutrition(4), Exercise and Physiological Responses(4), Mitochondrial Function and Pathology(3)

Publications23 total

Ulk1(S555) inhibition alters nutrient stress response by prioritizing amino acid metabolism
Molecular Metabolism·2025Open Access
NOX4 Selectively Modulates Skeletal Muscle Mitochondrial Bioenergetic and Membrane Potential in a Substrate-Dependent Manner
Free Radical Biology and Medicine·2025
Endothelial Nitric Oxide Synthase: a Critical Mediator of Fatty Acid Oxidation during Energetic Stress in Skeletal Muscle
Free Radical Biology and Medicine·2025
Distinct endothelial gene responses to acute exercise in skeletal muscle
American Journal of Physiology-Endocrinology and Metabolism·2025· 1 citedOpen Access
Ulk1(S555) inhibition alters nutrient stress response by prioritizing amino acid metabolism
2025Open Access
Sex-specific metabolic responses to high-fat diet in mice with NOX4 deficiency
Redox Biology·2025· 1 citedOpen Access
Loss of NOX4 results in a sexually dimorphic response to high fat diet feeding in liver, bone and muscle
Free Radical Biology and Medicine·2024Open Access
Neuromuscular Dysfunction Precedes Cognitive Impairment in a Mouse Model of Alzheimer’s Disease
Function·2023· 18 citedOpen Access
Crossroads of Nitric Oxide and Mitochondrial Metabolism: Implications for Skeletal Muscle Adaptations to Exercise
Free Radical Biology and Medicine·2023
Prolonged voluntary wheel running reveals unique adaptations in mdx mice treated with microdystrophin constructs ± the nNOS-binding site
Frontiers in Physiology·2023· 6 citedOpen Access
NOX4 Drives Exercise-Induced Mitophagy
Free Radical Biology and Medicine·2022
NOX4 deletion affects metabolic and bone parameters in animal model of high fat diet obesity
Bone Reports·2022Open Access
Voluntary wheel running complements microdystrophin gene therapy to improve muscle function in mdx mice
Molecular Therapy — Methods & Clinical Development·2021· 1 citedOpen Access
Voluntary wheel running complements microdystrophin gene therapy to improve muscle function in mdx mice
Molecular Therapy — Methods & Clinical Development·2021· 20 citedOpen Access
Nox4 mediates skeletal muscle metabolic responses to exercise
Molecular Metabolism·2021· 55 citedOpen Access
Nox4-derived ROS are Essential for Skeletal Muscle Substrate Oxidation Post-exercise
Free Radical Biology and Medicine·2020
Flavanol supplementation protects against obesity-associated increases in systemic interleukin-6 levels without inhibiting body mass gain in mice fed a high-fat diet
Nutrition Research·2019· 4 cited
Mice deficient in the mitochondrial branched-chain aminotransferase (BCATm) respond with delayed tumour growth to a challenge with EL-4 lymphoma
British Journal of Cancer·2018· 15 citedOpen Access
Branched-Chain Amino Acids and Brain Metabolism
Neurochemical Research·2017· 205 cited
Leucine acts in the brain to suppress food intake but does not function as a physiological signal of low dietary protein
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology·2014· 61 citedOpen Access
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Frequent Co-authors

Siobhan M. Craige(11), Ryan P. McMillan(8), Jacob Bond(8), Joshua C. Drake(7), Kalyn S. Specht(6), Susan M. Hutson(4), Robert W. Grange(4), Anna S. Nichenko(4), Charles P. Najt(4), Shelby E. Hamm(3), Michael W. Lawlor(3), Mariah J. Prom(3), Carl Morris(3), Matthew H. Brisendine(3), Orion S Willoughby(3), Niloufar Amiri(3), Rebecca M. Wall(3), Michaela Tencerová(3), Rebecca Mammel(3), Alexey V. Zaitsev(3)