Harriet V Mears

The Francis Crick Institute — United Kingdom

Medicine · Health Sciences

12h-index673citations28works12.02yr avg
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Research Topics

SARS-CoV-2 and COVID-19 Research(15), COVID-19 Clinical Research Studies(6), RNA Research and Splicing(4), Viral gastroenteritis research and epidemiology(4), Viral Infections and Immunology Research(4)

Publications28 total

IFIT3 controls IFIT1 accumulation and specificity preventing self mRNA targeting during the innate immune response
2025Open Access
Emergence of SARS-CoV-2 subgenomic RNAs that enhance viral fitness and immune evasion
PLoS Biology·2025· 24 citedOpen Access
Real-time estimation of immunological responses against emerging SARS-CoV-2 variants in the UK: a mathematical modelling study
The Lancet Infectious Diseases·2024· 6 citedOpen Access
ER-export and ARFRP1/AP-1–dependent delivery of SARS-CoV-2 Envelope to lysosomes controls late stages of viral replication
Science Advances·2024· 15 citedOpen Access
COVID-19 in non-hospitalised adults caused by either SARS-CoV-2 sub-variants Omicron BA.1, BA.2, BA.4/5 or Delta associates with similar illness duration, symptom severity and viral kinetics, irrespective of vaccination history
PLoS ONE·2024· 11 citedOpen Access
Combined analyses of within-host SARS-CoV-2 viral kinetics and information on past exposures to the virus in a human cohort identifies intrinsic differences of Omicron and Delta variants
PLoS Biology·2024· 16 citedOpen Access
SARS-CoV-2 mucosal neutralising immunity after vaccination
The Lancet Infectious Diseases·2023· 8 citedOpen Access
33 Fourth dose bivalent mRNA vaccines containing BA.1 significantly augment neutralising antibody titres against SARS-COV-2 Omicron sub-lineages XBB and BQ.1.1 in healthy adults
Clinical Infection in Practice·2023Open Access
34 COVID-19 caused by either Omicron sub-variants or Delta in non-hospitalised adults associates with similar illness duration, symptom severity and viral kinetics, irrespective of vaccination history
Clinical Infection in Practice·2023· 1 citedOpen Access
Neutralising immunity to omicron sublineages BQ.1.1, XBB, and XBB.1.5 in healthy adults is boosted by bivalent BA.1-containing mRNA vaccination and previous Omicron infection
The Lancet Infectious Diseases·2023· 32 citedOpen Access
Dichotomy of neutralizing antibody, B cell and T cell responses to SARS-CoV-2 vaccination and protection in healthy adults
2023· 3 citedOpen Access
Within-host SARS-CoV-2 viral kinetics informed by complex life course exposures reveals different intrinsic properties of Omicron and Delta variants
2023· 5 citedOpen Access
WHO's Therapeutics and COVID-19 Living Guideline on mAbs needs to be reassessed
The Lancet·2022· 53 citedOpen Access
COVID-19 in non-hospitalised adults caused by either SARS-CoV-2 sub-variants Omicron BA.1, BA.2, BA.5 or Delta associates with similar illness duration, symptom severity and viral kinetics, irrespective of vaccination history
2022· 5 citedOpen Access
Emergence of new subgenomic mRNAs in SARS-CoV-2
2022· 27 citedOpen Access
Three-dose vaccination elicits neutralising antibodies against omicron
The Lancet·2022· 99 citedOpen Access
ER-export and ARFRP1/AP-1-dependent delivery of SARS-CoV-2 Envelope to lysosomes controls late stages of viral replication
2021· 7 citedOpen Access
Mouse Ifit1b is a cap1-RNA–binding protein that inhibits mouse coronavirus translation and is regulated by complexing with Ifit1c
Journal of Biological Chemistry·2020· 12 citedOpen Access
The flavivirus polymerase NS5 regulates translation of viral genomic RNA
Nucleic Acids Research·2020· 35 citedOpen Access
On the expression, function and regulation of the murine Ifit family of antiviral RNA-binding proteins.
Apollo (University of Cambridge)·2019Open Access
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Frequent Co-authors

David L.V. Bauer(16), Emma Wall(14), Ruth Harvey(14), Bryan Williams(14), Sonia Gandhi(14), Charles Swanton(14), Edward J Carr(12), Hermaleigh Townsley(12), Rupert Beale(12), Trevor R. Sweeney(11), Mary Wu(11), Lorin Adams(11), Ashley S Fowler(11), Nicola O’Reilly(10), Edward Emmott(9), Gavin Kelly(9), George Kassiotis(9), Vincenzo Libri(9), Murad Miah(8), Callie Smith(8)