Christophe L. M. J. Verlinde

Biochemistry, Genetics and Molecular Biology · Life Sciences

48h-index7.7kcitations199works1.02yr avg
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Research Topics

Biochemical and Molecular Research(54), Trypanosoma species research and implications(52), HIV/AIDS drug development and treatment(34), RNA and protein synthesis mechanisms(33), Research on Leishmaniasis Studies(16)

Publications198 total

Towards a primary care based COVID-19 adult vaccination strategy in Flanders
International Journal of Integrated Care·2025· 1 citedOpen Access
Spontaneous Selection of <i>Cryptosporidium</i> Drug Resistance in a Calf Model of Infection
Antimicrobial Agents and Chemotherapy·2021· 29 citedOpen Access
Repurposing Infectious Disease Hits as Anti-<i>Cryptosporidium</i> Leads
ACS Infectious Diseases·2021· 10 citedOpen Access
Spontaneous selection of <i>Cryptosporidium</i> drug resistance in a calf model of infection
2021· 1 citedOpen Access
Structure-guided discovery of selective methionyl-tRNA synthetase inhibitors with potent activity against <i>Trypanosoma brucei</i>
RSC Medicinal Chemistry·2020· 15 citedOpen Access
Optimization of Methionyl tRNA-Synthetase Inhibitors for Treatment of <i>Cryptosporidium</i> Infection
Antimicrobial Agents and Chemotherapy·2019· 50 citedOpen Access
Antitrypanosomiasis Drug Development Based on Structures of Glycolytic Enzymes
2018· 10 cited
The crystal structure of the drug target<i>Mycobacterium tuberculosis</i>methionyl-tRNA synthetase in complex with a catalytic intermediate
Acta Crystallographica Section F Structural Biology Communications·2018· 15 citedOpen Access
The calcium-dependent protein kinase 1 from <i>Toxoplasma gondii</i> as target for structure-based drug design
Parasitology·2017· 27 citedOpen Access
Development of Methionyl-tRNA Synthetase Inhibitors as Antibiotics for Gram-Positive Bacterial Infections
Antimicrobial Agents and Chemotherapy·2017· 35 citedOpen Access
Leishmania donovani tyrosyl-tRNA synthetase structure in complex with a tyrosyl adenylate analog and comparisons with human and protozoan counterparts
Biochimie·2017· 16 citedOpen Access
Optimization of a binding fragment targeting the “enlarged methionine pocket” leads to potent Trypanosoma brucei methionyl-tRNA synthetase inhibitors
Bioorganic & Medicinal Chemistry Letters·2017· 18 citedOpen Access
Structure-guided design of novel Trypanosoma brucei Methionyl-tRNA synthetase inhibitors
European Journal of Medicinal Chemistry·2016· 30 citedOpen Access
5-Fluoroimidazo[4,5-<i>b</i>]pyridine Is a Privileged Fragment That Conveys Bioavailability to Potent Trypanosomal Methionyl-tRNA Synthetase Inhibitors
ACS Infectious Diseases·2016· 30 citedOpen Access
Inhibitors of Methionyl-tRNA Synthetase Have Potent Activity against Giardia intestinalis Trophozoites
Antimicrobial Agents and Chemotherapy·2015· 21 citedOpen Access
A binding hotspot in<i>Trypanosoma cruzi</i>histidyl-tRNA synthetase revealed by fragment-based crystallographic cocktail screens
Acta Crystallographica Section D Biological Crystallography·2015· 21 citedOpen Access
Identification of Potent Inhibitors of the Trypanosoma brucei Methionyl-tRNA Synthetase via High-Throughput Orthogonal Screening
SLAS DISCOVERY·2014· 41 citedOpen Access
Structure-based drug design against Trypanosoma brucei methionyl-tRNA synthetase
Acta Crystallographica Section A Foundations and Advances·2014Open Access
Structures of Trypanosoma brucei Methionyl-tRNA Synthetase with Urea-Based Inhibitors Provide Guidance for Drug Design against Sleeping Sickness
PLoS neglected tropical diseases·2014· 41 citedOpen Access
Development of potent and selective Plasmodium falciparum calcium-dependent protein kinase 4 (PfCDPK4) inhibitors that block the transmission of malaria to mosquitoes
European Journal of Medicinal Chemistry·2014· 63 cited
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Frequent Co-authors

Wim G. J. Hol(28), Wesley C. Van Voorhis(22), Frederick S. Buckner(19), Erkang Fan(15), Michael H. Gelb(14), E.A. Merritt(14), Zhongsheng Zhang(9), Kayode K. Ojo(9), Dustin J. Maly(8), E.T. Larson(6), Jessica E. Kim(6), J. Robert Gillespie(6), Molly C. Reid(5), Katelyn R. Keyloun(4), Ryan C. Murphy(4), Alberto J. Napuli(4), Anna M. W. Fox(4), Steven M. Johnson(4), Kasey Rivas(4), Ryan Choi(4)