J. S. Brimacombe

University of Dundee — United Kingdom

Chemistry · Physical Sciences

33h-index5.6kcitations610works0.02yr avg
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Research Topics

Carbohydrate Chemistry and Synthesis(249), Diet, Metabolism, and Disease(101), Glycosylation and Glycoproteins Research(86), Synthesis of Organic Compounds(37), Enzyme Catalysis and Immobilization(27)

Publications609 total

Some recent neighbouring-group participation and rearrangement reactions of carbohydrates
2006· 6 cited
Synthesis of a cell-permeable analogue of a glycosylphosphatidylinositol (GPI) intermediate that is toxic to the living bloodstream form of Trypanosoma brucei
Tetrahedron Letters·2005· 8 cited
In Vitro Biosynthesis of Glycosylphosphatidylinositol in <i>Aspergillus fumigatus</i>
Biochemistry·2004· 16 cited
Chemical validation of GPI biosynthesis as a drug target against African sleeping sickness
The EMBO Journal·2004· 77 citedOpen Access
The synthesis of some deoxygenated analogues of early intermediates in the biosynthesis of glycosylphosphatidylinositol (GPI) membrane anchors
Carbohydrate Research·2004· 7 cited
Further probing of the substrate specificities and inhibition of enzymes involved at an early stage of glycosylphosphatidylinositol (GPI) biosynthesis
Carbohydrate Research·2002· 18 cited
Specificities of Enzymes of Glycosylphosphatidylinositol Biosynthesis in Trypanosoma brucei and HeLa Cells
Journal of Biological Chemistry·2002· 20 citedOpen Access
Substrate Specificity of the<i>Plasmodium falciparum</i>Glycosylphosphatidylinositol Biosynthetic Pathway and Inhibition by Species-Specific Suicide Substrates
Biochemistry·2002· 28 cited
PARASITE-SPECIFIC SUICIDE SUBSTRATE INHIBITORS OF GlcNAc-PI DE-N-ACETYLASE IN THE GPI BIOSYNTHETIC PATHWAY
XXIst International Carbohydrate Symposium 2002·2002
GPI AND GLYCOPROTEIN BIOSYNTHESIS AS TARGETS FOR ANTI-PARASITE DRUG DESIGN
XXIst International Carbohydrate Symposium 2002·2002
SUBSTRATE ANALOGUES OF EARLY INTERMEDIATES IN THE BIOSYNTHETIC PATHWAY OF GLYCOSYLPHOSPHATIDYLINOSITOL MEMBRANE ANCHORS
XXIst International Carbohydrate Symposium 2002·2002
1,6:3,4-Dianhydro-2-azido-2-deoxy-β-<scp>D</scp>-galactopyranose
Acta Crystallographica Section E Structure Reports Online·2002
Methyl (2′<i>R</i>,3′<i>R</i>)-2-azido-2,6-dideoxy-3,4-<i>O</i>-(2′,3′-dimethoxybutane-2′,3′-diyl)-α-<scp>L</scp>-glucopyranoside
Acta Crystallographica Section E Structure Reports Online·2002· 1 cited
Methyl (2′<i>R</i>,3′<i>R</i>)-6-deoxy-3,4-<i>O</i>-(2′,3′-dimethoxybutane-2′,3′-diyl)-2-<i>O</i>-toluene-<i>p</i>-sulfonyl-α-<scp>L</scp>-mannopyranoside
Acta Crystallographica Section E Structure Reports Online·2002
CCDC 182597: Experimental Crystal Structure Determination
The Cambridge Structural Database·2002Open Access
CCDC 185804: Experimental Crystal Structure Determination
The Cambridge Structural Database·2002Open Access
CCDC 182598: Experimental Crystal Structure Determination
The Cambridge Structural Database·2002Open Access
ChemInform Abstract: Synthesis of 3′‐, 4′‐, and 6′‐Deoxy and Other Analogues of D‐Glucosaminylphosphatidylinositol.
ChemInform·2001
ChemInform Abstract: Analogues of D‐Glucosaminylphosphatidylinositol: Synthesis of the Glycosyl Donors.
ChemInform·2001
Synthesis of 3′-, 4′- and 6′-deoxy and other analogues of d -glucosaminylphosphatidylinositol
Tetrahedron Letters·2001· 6 cited
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Frequent Co-authors

Michael A. J. Ferguson(14), Terry Smith(7), M. Stacey(7), A. B. Foster(7), Arthur Crossman(5), Sylvain Cottaz(4), S. A. Barker(4), Andrei V. Nikolaev(3), Robert A. Field(3), Kenneth G. Milne(3), Deepak Sharma(3), J. M. Webber(3), M. C. Cook(3), D. H. Whiffen(3), A. K. M. S. KABIR(3), Georg Lundgren(2), Olof Theander(2), M.J. How(2), Anthony J. Rollins(2), Trevor J. Rutherford(2)