Jason D. Burch

Q Therapeutics (United States) — United States

Chemistry · Physical Sciences

19h-index1.3kcitations51works3.02yr avg
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Research Topics

Synthetic Organic Chemistry Methods(12), Asymmetric Synthesis and Catalysis(8), Inflammatory mediators and NSAID effects(8), Carbohydrate Chemistry and Synthesis(7), Microbial Natural Products and Biosynthesis(5)

Publications51 total

Structural insight into the cGAS active site explains differences between therapeutically relevant species
Communications Chemistry·2025· 10 citedOpen Access
Discovery of novel NLRP3 inhibitors enabled by a high-throughput screen
Bioorganic & Medicinal Chemistry Letters·2025
Discovery of Novel Nlrp3 Inhibitors Enabled by a High-Throughput Screen
SSRN Electronic Journal·2025Open Access
Discovery of Potent and Orally Bioavailable Pyrimidine Amide cGAS Inhibitors via Structure-Guided Hybridization
ACS Medicinal Chemistry Letters·2024· 2 citedOpen Access
Discovery of NXT-10796, an orally active, intestinally restricted EP4 agonist prodrug for the treatment of inflammatory bowel disease
Bioorganic & Medicinal Chemistry Letters·2023Open Access
NEGATIVE MODULATORS OF THE CGAS-STING PATHWAY
Medicinal chemistry reviews·2022· 2 cited
Total Synthesis of Aflastatin A
Journal of the American Chemical Society·2022· 9 cited
Could AlphaFold revolutionize chemical therapeutics?
Nature Structural & Molecular Biology·2021· 48 cited
Novel pyridone EP4 agonists featuring allylic alcohol ω-chains
Bioorganic & Medicinal Chemistry Letters·2020· 9 citedOpen Access
Aminoalkylation of [1.1.1]Propellane Enables Direct Access to High-Value 3-Alkylbicyclo[1.1.1]pentan-1-amines
Organic Letters·2019· 78 cited
Enantioselective synthesis of GNE-6688, a potent and selective inhibitor of interleukin-2 inducible T-cell kinase (ITK)
Tetrahedron Letters·2019· 3 cited
Scaffold-Hopping Approach To Discover Potent, Selective, and Efficacious Inhibitors of NF-κB Inducing Kinase
Journal of Medicinal Chemistry·2018· 51 citedOpen Access
Fragment Molecular Orbital Method Applied to Lead Optimization of Novel Interleukin-2 Inducible T-Cell Kinase (ITK) Inhibitors
Journal of Medicinal Chemistry·2016· 79 cited
Discovery and Development of Doravirine: An Investigational Next Generation Non-Nucleside Reverse Transcriptase Inhibitor (NNRTI) for the Treatment of HIV
ACS symposium series·2016· 5 cited
Inhibition of the kinase ITK in a mouse model of asthma reduces cell death and fails to inhibit the inflammatory response
Science Signaling·2015· 41 cited
Tetrahydroindazoles as Interleukin-2 Inducible T-Cell Kinase Inhibitors. Part II. Second-Generation Analogues with Enhanced Potency, Selectivity, and Pharmacodynamic Modulation in Vivo
Journal of Medicinal Chemistry·2015· 44 citedOpen Access
1,1′-Binaphthyl-2-[di(<i>tert</i>)-butyl]phosphine
Encyclopedia of Reagents for Organic Synthesis·2014
Design, synthesis and structure–activity relationships of a novel class of sulfonylpyridine inhibitors of Interleukin-2 inducible T-cell kinase (ITK)
Bioorganic & Medicinal Chemistry Letters·2014· 9 citedOpen Access
Property- and Structure-Guided Discovery of a Tetrahydroindazole Series of Interleukin-2 Inducible T-Cell Kinase Inhibitors
Journal of Medicinal Chemistry·2014· 40 citedOpen Access
Discovery and optimization of indazoles as potent and selective interleukin-2 inducible T cell kinase (ITK) inhibitors
Bioorganic & Medicinal Chemistry Letters·2014· 19 citedOpen Access
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Frequent Co-authors

David A. Evans(11), Alex G. Therien(7), Zhonghua Pei(7), Patsy Clark(6), Danielle Denis(6), Marie‐Claude Mathieu(6), Yongxin Han(6), Daniel F. Ortwine(6), Christian Eidamshaus(5), Georg Jaeschke(5), Paul McEwan(5), Moulay Hicham Alaoui Ismaili(5), Charles Eigenbrot(5), Xiaolu Wang(5), Stéphane Dorich(5), Valérie Dumais(5), Yves Ducharme(4), Daigen Xu(4), Amandine Chefson(4), Mark Wrona(4)