Karthik Sekar

SingHealth Duke-NUS Academic Medical Centre — Singapore

Medicine · Health Sciences

14h-index1.2kcitations34works3.52yr avg
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Research Topics

Ferroptosis and cancer prognosis(9), Cancer Mechanisms and Therapy(7), Cancer Genomics and Diagnostics(6), RNA modifications and cancer(5), Glioma Diagnosis and Treatment(4)

Publications34 total

PATH-68. Susceptibility of p53-mutant medulloblastomas (MB) to polo-like kinase 4 (PLK4) inhibition
Neuro-Oncology·2025Open Access
SAT-100-YI Multiomic insights into bile acid dysregulation, microbiome dysbiosis, and epigenetic modifications in metabolically associated non-B, non-C hepatocellular carcinoma: findings from multi-cohort studies and implications for early detection and therapeutic targeting
Journal of Hepatology·2025
Re-programming by a six-factor-secretome in the patient tumor ecosystem during nutrient stress and drug response
iScience·2024Open Access
A multimodal atlas of hepatocellular carcinoma reveals convergent evolutionary paths and ‘bad apple’ effect on clinical trajectory
Journal of Hepatology·2024· 14 citedOpen Access
Multi-region spatial transcriptome analysis reveals cellular networks and pathways associated with hepatocellular carcinoma recurrence
2023Open Access
A genomic enhancer signature associates with hepatocellular carcinoma prognosis
JHEP Reports·2023· 14 citedOpen Access
Multi-region sampling with paired sample sequencing analyses reveals sub-groups of patients with novel patient-specific dysregulation in Hepatocellular Carcinoma
BMC Cancer·2023· 6 citedOpen Access
Additional file 4 of Multi-region sampling with paired sample sequencing analyses reveals sub-groups of patients with novel patient-specific dysregulation in Hepatocellular Carcinoma
Figshare·2023Open Access
Additional file 1 of Multi-region sampling with paired sample sequencing analyses reveals sub-groups of patients with novel patient-specific dysregulation in Hepatocellular Carcinoma
Figshare·2023Open Access
Additional file 5 of Multi-region sampling with paired sample sequencing analyses reveals sub-groups of patients with novel patient-specific dysregulation in Hepatocellular Carcinoma
Figshare·2023Open Access
Additional file 7 of Multi-region sampling with paired sample sequencing analyses reveals sub-groups of patients with novel patient-specific dysregulation in Hepatocellular Carcinoma
Figshare·2023Open Access
Additional file 2 of Multi-region sampling with paired sample sequencing analyses reveals sub-groups of patients with novel patient-specific dysregulation in Hepatocellular Carcinoma
Figshare·2023Open Access
MEDB-08. Inhibition of different mitotic targets demonstrated distinct DNA damage and cell death response in p53-mutant medulloblastoma
Neuro-Oncology·2022· 1 citedOpen Access
The aberrant upregulation of exon 10-inclusive SREK1 through SRSF10 acts as an oncogenic driver in human hepatocellular carcinoma
Nature Communications·2022· 75 citedOpen Access
Abstract 634: Targeting metastatic brain germinoma using PDOX tumor models with sequential metastases
Cancer Research·2021
Maximizing the potential of aggressive mouse tumor models in preclinical drug testing
Scientific Reports·2021· 4 citedOpen Access
EMBR-23. KIF11 DEPENDENCY ON P53 MUTATIONAL STATUS IN MEDULLOBLASTOMA
Neuro-Oncology·2021· 1 citedOpen Access
Correlation of NUF2 Overexpression with Poorer Patient Survival in Multiple Cancers
Cancer Research and Treatment·2021· 27 citedOpen Access
Clinical and metabolomics analysis of hepatocellular carcinoma patients with diabetes mellitus
Metabolomics·2019· 17 cited
Relevance of a TCGA-derived Glioblastoma Subtype Gene-Classifier among Patient Populations
Scientific Reports·2019· 67 citedOpen Access
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Frequent Co-authors

Kam M. Hui(21), Brian K. P. Goh(17), London Lucien Ooi(11), Wan‐Yee Teo(10), Shay Lee Chong(10), Juinn Huar Kam(10), Vanessa H. de Villa(10), Glenn Kunnath Bonney(10), Pierce K. H. Chow(10), Veerabrahma Pratap Seshachalam(9), Lingyan Wu(9), Peng Chung Cheow(9), Alfred Wei Chieh Kow(9), Shridhar Ganpathi Iyer(9), Wei Qiang Leow(9), Xiao‐Nan Li(9), Jianxiang Chen(8), Raden Indah Kendarsari(8), Hannah Lai(8), Wen Huan Ling(8)