Mathew Blurton‐Jones

University of California, Irvine — United States

Neuroscience · Life Sciences

54h-index15.7kcitations202works12.62yr avg
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Research Topics

Neuroinflammation and Neurodegeneration Mechanisms(102), Alzheimer's disease research and treatments(64), Neurological Disease Mechanisms and Treatments(29), Neurogenesis and neuroplasticity mechanisms(26), Immune cells in cancer(26)

Publications201 total

Human iPSC-derived APOE4/4 Alzheimer´s disease astrocytes exhibit a senescent and pro-inflammatory state that compromises neuronal support
Journal of Neuroinflammation·2025Open Access
Loss of PILRA promotes microglial immunometabolism to reduce amyloid pathology in cell and mouse models of Alzheimer’s disease
Science Translational Medicine·2025· 1 cited
Microglia replacement by peripheral delivery of CSF1R inhibitor-resistant hematopoietic cells
Molecular Therapy·2025Open Access
CSF1R inhibitor-resistant model for CNS-wide microglia replacement strategies
Molecular Therapy·2025Open Access
Human microglia differentially respond to β‐amyloid, tau, and combined Alzheimer's disease pathologies in vivo
Alzheimer s & Dementia·2025· 2 citedOpen Access
Amyloid precursor protein and C99 are subunits in human microglial Hv1 channels that enhance current and inflammatory mediator release
Proceedings of the National Academy of Sciences·2025· 1 citedOpen Access
Microglia-specific regulation of lipid metabolism in Alzheimer’s disease revealed by microglial depletion in 5xFAD Mice
Nature Communications·2025· 2 citedOpen Access
Brain wide engraftment of human monocytes induces neurodegeneration and cognitive dysfunction
2025Open Access
Fluid and Neuroimaging Biomarkers in Microgliopathy Colony-Stimulating Factor-1 Receptor-Related Disorders
2025Open Access
Cerebrovascular alterations in a mouse model of late-onset Alzheimer’s disease
Neurophotonics·2025Open Access
Harnessing human iPSC-microglia for CNS-wide delivery of disease-modifying proteins
Cell stem cell·2025· 29 citedOpen Access
Immune checkpoint TIM-3 regulates microglia and Alzheimer’s disease
Nature·2025· 36 citedOpen Access
PILRA regulates microglial immunometabolism to reduce disease pathology as a candidate therapeutic target for Alzheimer’s disease
2025· 1 citedOpen Access
Retraction Note: Efficacy and immunogenicity of MultiTEP-based DNA vaccines targeting human α-synuclein: prelude for IND enabling studies
npj Vaccines·2025Open Access
Inhaled xenon modulates microglia and ameliorates disease in mouse models of amyloidosis and tauopathy
Science Translational Medicine·2025· 5 cited
Microglial APOE3 Christchurch protects neurons from Tau pathology in a human iPSC-based model of Alzheimer’s disease
Cell Reports·2024· 16 citedOpen Access
Microglia-Dependent and Independent Modulation of Brain Lipid Metabolism in Alzheimer’s Disease Revealed by Pharmacological and Genetic Microglial Depletion
2024Open Access
Circulatory proteins shape microglia state and boost phagocytosis
2024· 10 citedOpen Access
Microglia are not necessary for maintenance of blood-brain barrier properties in health, but PLX5622 alters brain endothelial cholesterol metabolism
Neuron·2024· 33 citedOpen Access
Organelle phenotyping and multi‐dimensional microscopy identify C1q as a novel regulator of microglial function
Journal of Neurochemistry·2024· 2 citedOpen Access
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Frequent Co-authors

Frank M. LaFerla(15), Hayk Davtyan(12), Wayne W. Poon(10), Jonathan Hasselmann(8), Carl W. Cotman(7), Amanda McQuade(7), Samuel E. Marsh(6), Christina Tu(6), Sepideh Kiani Shabestari(6), Jean Paul Chadarevian(6), Clare Pridans(5), David Hume(4), Kim N. Green(4), Robert A. Rissman(4), Salvatore Oddo(4), Morgan Coburn(4), Robert C. Spitale(4), Joy Davis(4), Mark H. Tuszynski(4), Christopher K. Glass(3)