Chih‐Chen Wang

Chinese Academy of Sciences — China

Biochemistry, Genetics and Molecular Biology · Life Sciences

19h-index1.4kcitations33works0.02yr avg
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Research Topics

Endoplasmic Reticulum Stress and Disease(17), Heat shock proteins research(9), Pancreatic function and diabetes(8), Enzyme Structure and Function(6), Protein Structure and Dynamics(4)

Publications33 total

Compensatory Increase of Serum Hepassocin Protects Hyperthyroidism-Induced Hepatic Dysfunction
Biomedicines·2023Open Access
Reducing oxidative protein folding alleviates senescence by minimizing ER‐to‐nucleus H <sub>2</sub> O <sub>2</sub> release
EMBO Reports·2023· 28 citedOpen Access
Real-World Comparative Evaluation of Add-On Glucagon-like Peptide 1 Receptor Agonist in Type 2 Diabetes Treated with or without Insulin
Pharmaceuticals·2022Open Access
Growth differentiation factor‐15 is independently associated with metabolic syndrome and hyperglycemia in non‐elderly subjects
BioFactors·2022· 9 cited
Two protein disulfide isomerase subgroups work synergistically in catalyzing oxidative protein folding
PLANT PHYSIOLOGY·2021· 18 citedOpen Access
Proteolytic processing of secretory pathway kinase Fam20C by site-1 protease promotes biomineralization
Proceedings of the National Academy of Sciences·2021· 35 citedOpen Access
Protein disulfide isomerase is regulated in multiple ways: Consequences for conformation, activities, and pathophysiological functions
BioEssays·2020· 34 cited
Phosphorylation switches protein disulfide isomerase activity to maintain proteostasis and attenuate ER stress
The EMBO Journal·2020· 98 citedOpen Access
The b′ domain of protein disulfide isomerase cooperates with the a and a′ domains to functionally interact with platelets
Journal of Thrombosis and Haemostasis·2018· 22 citedOpen Access
Secretory kinase Fam20C tunes endoplasmic reticulum redox state via phosphorylation of Ero1α
The EMBO Journal·2018· 72 citedOpen Access
Metformin alleviates human cellular aging by upregulating the endoplasmic reticulum glutathione peroxidase 7
Aging Cell·2018· 174 citedOpen Access
Structural Insights into the Redox-Regulated Dynamic Conformations of Human Protein Disulfide Isomerase
Antioxidants and Redox Signaling·2012· 213 cited
Thermal-Induced Dissociation and Unfolding of Homodimeric DsbC Revealed by Temperature-Jump Time-Resolved Infrared Spectra
Biophysical Journal·2009· 14 citedOpen Access
Crystal structure of human ERp44 shows a dynamic functional modulation by its carboxy‐terminal tail
EMBO Reports·2008· 69 citedOpen Access
Contributions of Cysteine Residues in Zn2 to Zinc Fingers and Thiol-Disulfide Oxidoreductase Activities of Chaperone DnaJ
Biochemistry·2005· 41 cited
Donor–Donor Energy‐Migration Measurements of Dimeric DsbC Labeled at Its N‐Terminal Amines with Fluorescent Probes: A Study of Protein Unfolding
Angewandte Chemie International Edition·2004· 26 cited
Donor–Donor Energy‐Migration Measurements of Dimeric DsbC Labeled at Its N‐Terminal Amines with Fluorescent Probes: A Study of Protein Unfolding
Angewandte Chemie·2004· 10 cited
[8] Protein disulfide isomerase as an enzyme and a chaperone in protein folding
Methods in enzymology on CD-ROM/Methods in enzymology·2002· 17 cited
Thermodynamics of the folding of D‐glyceraldehyde‐3‐phosphate dehydrogenase assisted by protein disulfide isomerase studied by microcalorimetry
European Journal of Biochemistry·2001· 10 citedOpen Access
GroEL-Assisted Dehydrogenase Folding Mediated by Coenzyme Is ATP-Independent
Biochemical and Biophysical Research Communications·2001· 6 cited
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Frequent Co-authors

Lei Wang(9), Chen‐Lu Tsou(7), Jian Li(4), Huimin Ke(3), Wang Xie(3), Jiaojiao Yu(3), Jianchao Zhang(3), Hung‐Tsung Wu(3), Hsuan‐Wen Chou(3), Ching‐Han Lin(3), Horng‐Yih Ou(3), Jingqi Fang(2), Guang‐Hui Liu(2), Likun Wang(2), Xinxin Chen(2), Junyu Xiao(2), Lu Wang(2), Jianping Ye(2), Andong Xia(2), Guoqiang Yang(2)