Emmanuel Darcq

Biochemistry, Genetics and Molecular Biology · Life Sciences

30h-index3.0kcitations116works2.92yr avg
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Research Topics

Receptor Mechanisms and Signaling(46), Neurotransmitter Receptor Influence on Behavior(43), Neuropeptides and Animal Physiology(39), Neuroscience and Neuropharmacology Research(18), Pharmacological Receptor Mechanisms and Effects(14)

Publications116 total

The orphan receptor GPR88 controls impulsivity and is a risk factor for Attention-Deficit/Hyperactivity Disorder.
Apollo (University of Cambridge)·2026Open Access
IFNγ-associated immune–metabolic remodeling drives serotonin–kynurenine imbalance with cortical vulnerability in lupus-prone mice
2025Open Access
Incubation of social deficit during morphine abstinence in male mice using a novel unbiased and automatized method
Frontiers in Behavioral Neuroscience·2025Open Access
Sex-divergent brain epigenetic reprogramming by chronic opioids
2025· 1 citedOpen Access
The neural circuits and signalling pathways of opioid use disorder
Nature reviews. Neuroscience·2025· 3 cited
The GPR88 Agonist RTI‐122 Reduces Alcohol‐Related Motivation and Consumption
Addiction Biology·2025· 1 citedOpen Access
Discovery of BI-9508, a Brain-Penetrant GPR88-Receptor-Agonist Tool Compound for <i>In Vivo</i> Mouse Studies
Journal of Medicinal Chemistry·2024· 1 cited
Model of negative affect induced by withdrawal from acute and chronic morphine administration in male mice
Scientific Reports·2024· 17 citedOpen Access
Neuroscience and addiction research: current advances and perspectives
Journal of Neural Transmission·2024· 6 citedOpen Access
Implication of habenular neurons expressing mu opioid receptors in negative affect associated with naloxone precipitated morphine withdrawal
Neuroscience Applied·2024Open Access
Chronic Morphine Leaves a Durable Fingerprint on Whole-Brain Functional Connectivity
Biological Psychiatry·2023· 8 citedOpen Access
Manipulating ΔFOSB in D1-Type Medium Spiny Neurons of the Nucleus Accumbens Reshapes Whole-Brain Functional Connectivity
Biological Psychiatry·2023· 4 citedOpen Access
Mu Opioid Receptor–Positive Neurons in the Dorsal Raphe Nucleus Are Impaired by Morphine Abstinence
Biological Psychiatry·2023· 17 citedOpen Access
Mu Opioid Receptor–Expressing Neurons in the Dorsal Raphe Nucleus Are Involved in Reward Processing and Affective Behaviors
Biological Psychiatry·2023· 25 citedOpen Access
Chronic tianeptine induces tolerance in analgesia and hyperlocomotion via mu-opioid receptor activation in mice
Frontiers in Psychiatry·2023· 7 citedOpen Access
Advances in the characterization of negative affect caused by acute and protracted opioid withdrawal using animal models
Neuropharmacology·2023· 33 citedOpen Access
Improvement of the Metabolic Stability of GPR88 Agonist RTI-13951-33: Design, Synthesis, and Biological Evaluation
Journal of Medicinal Chemistry·2023· 12 citedOpen Access
Striatal μ-opioid receptor activation triggers direct-pathway GABAergic plasticity and induces negative affect
Cell Reports·2023· 28 citedOpen Access
Synthesis and pharmacological validation of a novel radioligand for the orphan GPR88 receptor
Bioorganic & Medicinal Chemistry Letters·2022· 3 citedOpen Access
Reduced dopamine release in Dcc haploinsufficiency male mice abolishes the rewarding effects of cocaine but not those of morphine and ethanol
Psychopharmacology·2022· 2 citedOpen Access
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Frequent Co-authors

Brigitte L. Kieffer(37), Sami Ben Hamida(15), Dorit Ron(9), Aliza T. Ehrlich(9), Katia Befort(8), Md Taufiq Nasseef(6), Vincent Warnault(5), Khanhky Phamluong(5), Audrey Matifas(5), Julie Bailly(5), Claire Gavériaux‐Ruff(5), Laura Harsan(5), Laura‐Joy Boulos(4), Dominique Filliol(4), Michael McNicholas(4), Florence Allain(4), Jun Wang(3), Doulaye Dembélé(3), Florence Gross(3), Lola Welsch(3)