Juan A. Sánchez‐Arias

Universidad de Navarra — Spain

Medicine · Health Sciences

19h-index1.2kcitations36works0.02yr avg
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Research Topics

Pancreatic function and diabetes(9), Histone Deacetylase Inhibitors Research(9), Cholinesterase and Neurodegenerative Diseases(7), Phosphodiesterase function and regulation(6), Diet, Metabolism, and Disease(6)

Publications36 total

Design and Synthesis of Novel Epigenetic Inhibitors Targeting Histone Deacetylases, DNA Methyltransferase 1, and Lysine Methyltransferase G9a with <i>In Vivo</i> Efficacy in Multiple Myeloma
Journal of Medicinal Chemistry·2021· 29 citedOpen Access
A Case Control Study Demonstrates an Increase in Plasma Amylin Associated with Chronic Migraine
SSRN Electronic Journal·2020· 1 citedOpen Access
Multitarget Approach for the Treatment of Alzheimer’s Disease: Inhibition of Phosphodiesterase 9 (PDE9) and Histone Deacetylases (HDACs) Covering Diverse Selectivity Profiles
ACS Chemical Neuroscience·2019· 41 cited
Amylin as a potential link between type 2 diabetes and alzheimer disease
Annals of Neurology·2019· 106 cited
Taking Advantage of the Selectivity of Histone Deacetylases and Phosphodiesterase Inhibitors to Design Better Therapeutic Strategies to Treat Alzheimer’s Disease
Frontiers in Aging Neuroscience·2019· 43 citedOpen Access
Targeting CB1 and GPR55 Endocannabinoid Receptors as a Potential Neuroprotective Approach for Parkinson’s Disease
Molecular Neurobiology·2019· 33 citedOpen Access
Discovery of <i>in Vivo</i> Chemical Probes for Treating Alzheimer’s Disease: Dual Phosphodiesterase 5 (PDE5) and Class I Histone Deacetylase Selective Inhibitors
ACS Chemical Neuroscience·2018· 36 cited
Discovery of Reversible DNA Methyltransferase and Lysine Methyltransferase G9a Inhibitors with Antitumoral in Vivo Efficacy
Journal of Medicinal Chemistry·2018· 60 citedOpen Access
Glucocerebrosidase Mutations and Synucleinopathies. Potential Role of Sterylglucosides and Relevance of Studying Both GBA1 and GBA2 Genes
Frontiers in Neuroanatomy·2018· 26 citedOpen Access
Detailed Exploration around 4-Aminoquinolines Chemical Space to Navigate the Lysine Methyltransferase G9a and DNA Methyltransferase Biological Spaces
Journal of Medicinal Chemistry·2018· 31 citedOpen Access
Phenotypic Screening To Discover Novel Chemical Series as Efficient Antihemorrhagic Agents
ACS Medicinal Chemistry Letters·2018· 2 citedOpen Access
Design, synthesis, biological evaluation and in vivo testing of dual phosphodiesterase 5 (PDE5) and histone deacetylase 6 (HDAC6)-selective inhibitors for the treatment of Alzheimer's disease
European Journal of Medicinal Chemistry·2018· 67 citedOpen Access
CM352 Reduces Brain Damage and Improves Functional Recovery in a Rat Model of Intracerebral Hemorrhage
Journal of the American Heart Association·2017· 32 citedOpen Access
Discovery of first-in-class reversible dual small molecule inhibitors against G9a and DNMTs in hematological malignancies
Nature Communications·2017· 162 citedOpen Access
Inducing heat shock protein 70 expression provides a robust anti-thrombotic effect with minimal bleeding risk
Thrombosis and Haemostasis·2017· 9 cited
Impact of Scaffold Exploration on Novel Dual-Acting Histone Deacetylases and Phosphodiesterase 5 Inhibitors for the Treatment of Alzheimer’s Disease
ACS Chemical Neuroscience·2016· 34 cited
Design, Synthesis, and Biological Evaluation of First-in-Class Dual Acting Histone Deacetylases (HDACs) and Phosphodiesterase 5 (PDE5) Inhibitors for the Treatment of Alzheimer’s Disease
Journal of Medicinal Chemistry·2016· 85 citedOpen Access
A First-in-Class Small-Molecule that Acts as a Dual Inhibitor of HDAC and PDE5 and that Rescues Hippocampal Synaptic Impairment in Alzheimer’s Disease Mice
Neuropsychopharmacology·2016· 103 citedOpen Access
Two Affinity Sites of the Cannabinoid Subtype 2 Receptor Identified by a Novel Homogeneous Binding Assay
Journal of Pharmacology and Experimental Therapeutics·2016· 24 citedOpen Access
Neuroprotective Effect of JZL184 in MPP+-Treated SH-SY5Y Cells Through CB2 Receptors
Molecular Neurobiology·2015· 44 cited
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Frequent Co-authors

Julen Oyarzábal(19), Obdulia Rabal(16), Ana Ugarte(13), Irene de Miguel(11), Musheng Xu(10), Juan E. Felı́u(10), Elena Sáez(9), Mar Cuadrado‐Tejedor(7), Marta Pérez-González(7), Ana Garcı́a-Osta(7), Tan Haizhong(7), B Samper(7), Carolina García(6), Wei Wu(6), Edurne San José‐Eneriz(5), Xabier Agirre(5), Estíbaliz Miranda(5), Ander Estella‐Hermoso de Mendoza(5), Felipe Prósper(5), Rafael Franco(5)