Alison J. Howells

Norwich University — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

13h-index929citations16works0.02yr avg
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Research Topics

Cancer therapeutics and mechanisms(12), DNA Repair Mechanisms(4), DNA and Nucleic Acid Chemistry(4), Bacteriophages and microbial interactions(3), Bioactive Compounds and Antitumor Agents(3)

Publications16 total

Discovery of a Novel DNA Gyrase-Targeting Antibiotic through the Chemical Perturbation of Streptomyces venezuelae Sporulation
Cell chemical biology·2019· 23 citedOpen Access
Structure-guided design of antibacterials that allosterically inhibit DNA gyrase
Bioorganic & Medicinal Chemistry Letters·2019· 35 citedOpen Access
Functionalised bicyclic tetramates derived from cysteine as antibacterial agents
Organic & Biomolecular Chemistry·2019· 12 citedOpen Access
CCDC 1904326: Experimental Crystal Structure Determination
The Cambridge Structural Database·2019Open Access
Palliative care in heart failure – results from systematic audits in an acute trust
BMJ Supportive & Palliative Care·2012
Dissection of the Bacteriophage Mu Strong Gyrase Site (SGS): Significance of the SGS Right Arm in Mu Biology and DNA Gyrase Mechanism
Journal of Bacteriology·2005· 31 citedOpen Access
Simocyclinone D8, an Inhibitor of DNA Gyrase with a Novel Mode of Action
Antimicrobial Agents and Chemotherapy·2005· 113 citedOpen Access
Overexpression and Purification of Bacterial DNA Gyrase
Humana Press eBooks·2003· 67 cited
A biochemical analysis of the interaction of DNA gyrase with the bacteriophage Mu, pSC101 and pBR322 strong gyrase sites: the role of DNA sequence in modulating gyrase supercoiling and biological activity
Molecular Microbiology·2003· 24 cited
Ciprofloxacin affects conformational equilibria of DNA gyrase A in the presence of magnesium ions
Journal of Molecular Biology·2001· 59 cited
Locking the ATP-operated clamp of DNA gyrase: probing the mechanism of strand passage
Journal of Molecular Biology·2001· 66 cited
The interaction of DNA gyrase with the bacterial toxin CcdB: evidence for the existence of two gyrase-CcdB complexes 1 1Edited by I. B. Holland
Journal of Molecular Biology·1999· 39 cited
The interaction of the F plasmid killer protein, CcdB, with DNA gyrase: induction of DNA cleavage and blocking of transcription 1 1J. Karn
Journal of Molecular Biology·1997· 89 cited
Immunogold localization of GyrA and GyrB proteins in Escherichia coli
Microbiology·1994· 27 cited
The 43-kilodalton N-terminal fragment of the DNA gyrase B protein hydrolyzes ATP and binds coumarin drugs
Biochemistry·1993· 303 cited
Clerocidin, a terpenoid antibiotic, inhibits bacterial DNA gyrase.
The Journal of Antibiotics·1993· 41 citedOpen Access

Frequent Co-authors

Anthony Maxwell(14), Mark Oram(2), Martin L. Pato(2), Tharindi Panduwawala(2), Amber L. Thompson(2), Miroslav Genov(2), Alexander Pretsch(2), Dagmar Pretsch(2), Richard H. Ebright(2), Mark G. Moloney(2), Janid A. Ali(1), Andrew P. Jackson(1), Ruth H. Flatman(1), Lutz Heide(1), Hans‐Peter Fiedler(1), Susan E. Critchlow(1), M H O'Dea(1), Martine Couturier(1), Martin Gellert(1), Nicola L. Williams(1)