Dominique Charmot

Ardelyx (United States) — United States

Immunology and Microbiology · Life Sciences

26h-index3.0kcitations87works0.02yr avg
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Research Topics

T-cell and B-cell Immunology(35), Immune Cell Function and Interaction(22), Immunotherapy and Immune Responses(21), Advanced Polymer Synthesis and Characterization(20), Monoclonal and Polyclonal Antibodies Research(8)

Publications86 total

Discovery of Tenapanor: A First-in-Class Minimally Systemic Inhibitor of Intestinal Na<sup>+</sup>/H<sup>+</sup> Exchanger Isoform 3
ACS Medicinal Chemistry Letters·2022· 22 citedOpen Access
Design of Gut-Restricted Thiazolidine Agonists of G Protein-Coupled Bile Acid Receptor 1 (GPBAR1, TGR5)
Journal of Medicinal Chemistry·2018· 33 citedOpen Access
Development and Characterization of a Human and Mouse Intestinal Epithelial Cell Monolayer Platform
Stem Cell Reports·2017· 168 citedOpen Access
Preclinical and Healthy Volunteer Studies of Potential Drug–Drug Interactions Between Tenapanor and Phosphate Binders
Clinical Pharmacology in Drug Development·2016· 18 citedOpen Access
Gastrointestinal Inhibition of Sodium-Hydrogen Exchanger 3 Reduces Phosphorus Absorption and Protects against Vascular Calcification in CKD
Journal of the American Society of Nephrology·2014· 104 citedOpen Access
Intestinal Inhibition of the Na <sup>+</sup> /H <sup>+</sup> Exchanger 3 Prevents Cardiorenal Damage in Rats and Inhibits Na <sup>+</sup> Uptake in Humans
Science Translational Medicine·2014· 146 cited
Non-Systemic Drugs: A Critical Review
Current Pharmaceutical Design·2012· 76 citedOpen Access
The Safety, Tolerability, Systemic Exposure, and Effect on Bowel Habits of Single and Multiple Doses of the Intestinal Sodium Re-Uptake Inhibitor RDX5791 in Normal Healthy Volunteers
The American Journal of Gastroenterology·2011· 5 cited
RDX5791, a First-in-Class Minimally Systemic NHE3 Inhibitor in Clinical Development for CIC and IBS-C, Increases Intestinal Sodium Leading to Enhanced Intestinal Fluid Volume and Transit
Gastroenterology·2011· 16 cited
Visceral Antinociceptive Effects of RDX5791, a First-in-Class Minimally Systemic NHE3 Inhibitor on Stress-Induced Colorectal Hypersensitivity to Distension in Rats
Gastroenterology·2011· 14 cited
The phospholipase A<sub>2</sub> inhibitor methyl indoxam suppresses diet‐induced obesity and glucose intolerance in mice
British Journal of Pharmacology·2009· 50 citedOpen Access
Preparation of monodisperse, magnetizable, composite metal/polymer microspheres
Steinkopff eBooks·2007· 18 cited
Method for preparing latex by emulsion (co)polymerization of ethylenically unsaturated monomers, with direct inline monitoring by Raman spectroscopy.
HAL (Le Centre pour la Communication Scientifique Directe)·2004
Modeling of Seeded Semibatch Emulsion Polymerization of <i>n</i>-BA
Industrial & Engineering Chemistry Research·2001· 119 cited
High throughput synthesis and screening in specialty polymers applications.
Lancaster EPrints (Lancaster University)·2001· 2 cited
Kinetics and Polymer Microstructure of the Seeded Semibatch Emulsion Copolymerization of <i>n</i>-Butyl Acrylate and Styrene
Macromolecules·2001· 104 cited
Seeded semibatch emulsion polymerization of butyl acrylate: Effect of the chain‐transfer agent on the kinetics and structural properties
Journal of Polymer Science Part A Polymer Chemistry·2001· 1 cited
Seeded semibatch emulsion polymerization of butyl acrylate: Effect of the chain-transfer agent on the kinetics and structural properties
Journal of Polymer Science Part A Polymer Chemistry·2001· 85 cited
Dithiocarbamates as universal reversible addition-fragmentation chain transfer agents
Macromolecular Rapid Communications·2000· 329 cited
Seeded Semibatch Emulsion Polymerization of<i>n</i>-Butyl Acrylate. Kinetics and Structural Properties
Macromolecules·2000· 169 cited
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Frequent Co-authors

Claude Mawas(22), Kenji Kozuka(6), Samantha Koo-McCoy(6), Andrew Spencer(6), Jill Kohler(6), Marc Navre(6), Christophe Plessis(5), Gurutze Arzamendi(5), José R. Leiza(5), Harold A. S. Schoonbrood(5), José M. Asúa(5), Michael R. Leadbetter(5), Limin He(5), Eric D. Labonté(5), Christopher W. Carreras(5), Noah Bell(5), Jeffrey Jacobs(5), Bernard Malissen(5), Jason G. Lewis(3), Stephen Shaw(3)