Isabel Rodríguez‐Escudero

Universidad Complutense de Madrid — Spain

Biochemistry, Genetics and Molecular Biology · Life Sciences

19h-index1.2kcitations40works0.02yr avg
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Research Topics

PI3K/AKT/mTOR signaling in cancer(16), Escherichia coli research studies(8), Bacterial Genetics and Biotechnology(7), Fungal and yeast genetics research(6), Protein Kinase Regulation and GTPase Signaling(5)

Publications40 total

A trans-kingdom T6SS effector induces the fragmentation of the mitochondrial network and activates innate immune receptor NLRX1 to promote infection
Nature Communications·2023· 51 citedOpen Access
Functional analysis of PTEN variants of unknown significance from PHTS patients unveils complex patterns of PTEN biological activity in disease
European Journal of Human Genetics·2022· 6 citedOpen Access
A global analysis of the reconstitution of PTEN function by translational readthrough of<i>PTEN</i>pathogenic premature termination codons
Human Mutation·2021· 15 cited
BtpA and BtpB TIR filaments are not coincident with yeast tubulin.
Figshare·2020Open Access
Functional analyses in yeast loss-of-function mutations in conserved residues of BtpB.
Figshare·2020Open Access
Inhibitory effect of BtpB on phosphorylation of yeast signaling proteins.
Figshare·2020Open Access
Partial suppression of BtpB toxicity by overexpression of yeast genes.
Figshare·2020Open Access
The TIR-domain containing effectors BtpA and BtpB from Brucella abortus impact NAD metabolism
PLoS Pathogens·2020· 69 citedOpen Access
BtpB loss-of-function mutants found by random mutagenesis screening on yeast.
Figshare·2020Open Access
Expression of BtpB and BtpA versions in yeast and in inhibition of yeast endocytosis by the TIR domain of BtpB.
Figshare·2020Open Access
Oligonucleotides used in this work.
Figshare·2020Open Access
Yeast genes that suppress BtpB-induced toxicity when overexpressed.
Figshare·2020Open Access
Plasmids generated and used in this work.
Figshare·2020Open Access
Klebsiella pneumoniae type VI secretion system-mediated microbial competition is PhoPQ controlled and reactive oxygen species dependent
PLoS Pathogens·2020· 127 citedOpen Access
Expression of Human PTEN-L in a Yeast Heterologous Model Unveils Specific N-Terminal Motifs Controlling PTEN-L Subcellular Localization and Function
Cells·2019· 10 citedOpen Access
The TIR-domain containing effectors BtpA and BtpB from <i>Brucella abortus</i> block energy metabolism
2019· 2 citedOpen Access
<i>Klebsiella pneumoniae</i> type VI secretion system-mediated microbial competition is PhoPQ controlled and reactive oxygen species dependent
2019· 1 citedOpen Access
Modeling human disease in yeast: recreating the PI3K-PTEN-Akt signaling pathway in Saccharomyces cerevisiae
International Microbiology·2019· 20 cited
Heterologous mammalian Akt disrupts plasma membrane homeostasis by taking over TORC2 signaling in Saccharomyces cerevisiae
Scientific Reports·2018· 8 citedOpen Access
A pathogenic role for germline PTEN variants which accumulate into the nucleus
European Journal of Human Genetics·2018· 23 citedOpen Access
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Frequent Co-authors

Marı́a Molina(39), Vı́ctor J. Cid(39), Rafael Pulido(13), Julia María Coronas-Serna(12), María Rodríguez-Escudero(12), Arthur Louche(11), Morgane Roussin(11), Paul R. C. Imbert(11), Jean‐Pierre Gorvel(11), Suzana P. Salcedo(11), Laurent Terradot(10), Teresa Fernández‐Acero(9), Janire Mingo(6), Sandra Luna(6), Amparo Andrés‐Pons(4), Rafael Rotger(4), José I. López(4), Joana Sá‐Pessoa(3), Helina Marshall(3), José A. Bengoechea(3)