Dónal O’Carroll

MRC Centre for Regenerative Medicine — United Kingdom

Biochemistry, Genetics and Molecular Biology · Life Sciences

50h-index21.8kcitations91works16.12yr avg
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Research Topics

MicroRNA in disease regulation(25), RNA Research and Splicing(23), RNA modifications and cancer(21), Epigenetics and DNA Methylation(20), Chromosomal and Genetic Variations(18)

Publications91 total

A mammalian-like piRNA pathway in Axolotl reveals the origins of piRNA-directed DNA methylation
The EMBO Journal·2025· 2 citedOpen Access
A new double reporter strategy reveals a subset of non-migratory hematopoietic stem cells localized in a dynamic bone marrow niche
2025Open Access
Targeting Cis-regulatory elements for CRISPR-mediated transcriptional activation of the human MIR503HG locus
Vascular Pharmacology·2025· 1 citedOpen Access
Loss of conserved long non-coding RNA MIR503HG leads to altered NOTCH pathway signalling and left ventricular non-compaction cardiomyopathy
Cardiovascular Research·2025· 6 citedOpen Access
PROSER1 modulates DNA demethylation through dual mechanisms to prevent syndromic developmental malformations
Genes & Development·2024· 4 citedOpen Access
Two-factor authentication underpins the precision of the piRNA pathway
Nature·2024· 23 citedOpen Access
Inherited defects of piRNA biogenesis cause transposon de-repression, impaired spermatogenesis, and human male infertility
Nature Communications·2024· 48 citedOpen Access
PROSER1 Modulates DNA Demethylation through Dual Mechanisms to Prevent Syndromic Developmental Malformations
2024Open Access
The selective prolyl hydroxylase inhibitor IOX5 stabilizes HIF-1α and compromises development and progression of acute myeloid leukemia
Nature Cancer·2024· 32 citedOpen Access
MIWI N-terminal arginines orchestrate generation of functional pachytene piRNAs and spermiogenesis
Nucleic Acids Research·2024· 13 citedOpen Access
C19ORF84 connects piRNA and DNA methylation machineries to defend the mammalian germ line
Molecular Cell·2024· 29 citedOpen Access
Inherited defects of piRNA biogenesis cause transposon de-repression, impaired spermatogenesis, and human male infertility
2024· 4 citedOpen Access
A time- and single-cell-resolved model of murine bone marrow hematopoiesis
Cell stem cell·2024· 63 citedOpen Access
MIWI arginines orchestrate generation of functional pachytene piRNAs and spermiogenesis
2024· 1 citedOpen Access
The DUF3715 domain has a conserved role in RNA-directed transposon silencing
RNA·2023· 11 citedOpen Access
Abstract 447: Genetic and pharmacological inhibition of TUT4 and TUT7 sensitizes AML cells to BCL-2 inhibition
Cancer Research·2023
Targeting HIF-Hydroxylases Compromises Disease Initiation and Propagation, and Synergises with Current Therapies to Eliminate Cancer Stem Cells in AML
Blood·2022
Genetic and Pharmacological Inhibition of TUT4/TUT7 Sensitizes AML Cells to BCL-2 Inhibition
Blood·2022
Structural and functional basis of mammalian microRNA biogenesis by Dicer
Molecular Cell·2022· 74 citedOpen Access
A time and single-cell resolved model of hematopoiesis
2022· 1 citedOpen Access
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Frequent Co-authors

Marcos Morgan(10), Alexander Tarakhovsky(9), Anton J. Enright(9), Christian Much(8), Monica Di Giacomo(8), Thomas Jenuwein(7), M. Azim Surani(7), Ivayla Ivanova(5), Kamil R. Kranc(5), K. Rasmussen(5), Stefano Comazzetto(5), Sheila C. Barton(4), Masahiro Kaneda(4), Kaiqin Lao(4), Hannah Lawson(4), Lewis Allen(4), Pedro N. Moreira(4), Claudia Carrieri(4), Lina Vasiliauskaitė(4), Stephen Rea(3)