Saskia Milton

University of California, Irvine — United States

Medicine · Health Sciences

22h-index9.0kcitations45works0.02yr avg
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Research Topics

Alzheimer's disease research and treatments(22), Chemical Synthesis and Analysis(9), Prion Diseases and Protein Misfolding(9), Computational Drug Discovery Methods(7), Neuroinflammation and Neurodegeneration Mechanisms(6)

Publications45 total

Familial Alzheimer’s Disease Mutations within the Amyloid Precursor Protein Alter the Aggregation and Conformation of the Amyloid-β Peptide
Journal of Biological Chemistry·2017· 150 citedOpen Access
Structural differences between amyloid beta oligomers
Biochemical and Biophysical Research Communications·2016· 75 citedOpen Access
Monoclonal Antibodies against Aβ42 Fibrils Distinguish Multiple Aggregation State Polymorphisms in Vitro and in Alzheimer Disease Brain
Journal of Biological Chemistry·2014· 124 citedOpen Access
Intracellular amyloid and the neuronal origin of Alzheimer neuritic plaques
Neurobiology of Disease·2014· 126 citedOpen Access
Nonhuman Amyloid Oligomer Epitope Reduces Alzheimer’s-Like Neuropathology in 3xTg-AD Transgenic Mice
Molecular Neurobiology·2013· 10 cited
Structure of a C-terminal AHNAK peptide in a 1:2:2 complex with S100A10 and an acetylated N-terminal peptide of annexin A2
Acta Crystallographica Section D Biological Crystallography·2012· 24 citedOpen Access
Vaccination with a non-human random sequence amyloid oligomer mimic results in improved cognitive function and reduced plaque deposition and micro hemorrhage in Tg2576 mice
Molecular Neurodegeneration·2012· 38 citedOpen Access
The Oncogenic Jaagsiekte Sheep Retrovirus Cytoplasmic Tail Adopts a Unique Conformation on a Phosphocholine Surface
Biophysical Journal·2012· 1 citedOpen Access
Improving the Fmoc Solid Phase Synthesis of the Cyclic Hexapeptide Complement C5a Antagonist, PMX205
International Journal of Peptide Research and Therapeutics·2011· 5 cited
Vaccination with a non-human sequence amyloid oligomer mimic results in improved cognitive function and reduced plaque deposition in Tg2576 mice
Neuroscience Research·2011
Amyloid Oligomers Increase the Lifetime and Single Channel Conductance of Gramicidin Channels
Biophysical Journal·2011Open Access
Linear and conformation specific antibodies in aged beagles after prolonged vaccination with aggregated Abeta
Neurobiology of Disease·2010· 21 citedOpen Access
Dependence of Amyloid-β Oligomer (AβO) Interaction with Membranes on Preparation Method
Biophysical Journal·2010Open Access
Amyloid Oligomers Increase the Lifetime and Single Channel Conductance of Gramicidin Channels
Biophysical Journal·2010Open Access
Amyloid Oligomers Alter The Conductance Of The Gramicidin Channel
Biophysical Journal·2009Open Access
A Two-Year Study with Fibrillar β-Amyloid (Aβ) Immunization in Aged Canines: Effects on Cognitive Function and Brain Aβ
Journal of Neuroscience·2008· 101 citedOpen Access
Methylene Blue Inhibits Amyloid Aβ Oligomerization by Promoting Fibrillization
Biochemistry·2007· 208 cited
Pore-Forming Proteins Share Structural and Functional Homology with Amyloid Oligomers
NeuroMolecular Medicine·2007· 79 cited
Small Molecule Inhibitors of Aggregation Indicate That Amyloid β Oligomerization and Fibrillization Pathways Are Independent and Distinct
Journal of Biological Chemistry·2007· 677 citedOpen Access
Immunization with fibrillar Aβ1–42 in young and aged canines: Antibody generation and characteristics, and effects on CSF and brain Aβ
Vaccine·2006· 19 cited
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Frequent Co-authors

Charles Glabe(24), Rakez Kayed(9), Raymond C. de L. Milton(7), Suhail Rasool(6), R. C. deLisle Milton(6), Yuri Sokolov(5), James E. Hall(5), R. C. Milton(5), Elizabeth Head(4), Leonid Breydo(4), Ricardo Albay(4), Jessica Wu(4), Theresa M. McIntire(3), Asa Hatami(3), Vitaly Vasilevko(3), Edward G. Barrett(3), Charles Glabe(3), Martina Schnölzer(3), Stephen B. H. Kent(3), Steven A. Kates(3)