Grant A. Challen

Washington University in St. Louis — United States

Medicine · Health Sciences

38h-index7.6kcitations226works1.02yr avg
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Research Topics

Acute Myeloid Leukemia Research(133), Myeloproliferative Neoplasms: Diagnosis and Treatment(58), Epigenetics and DNA Methylation(50), Hematopoietic Stem Cell Transplantation(48), Hematological disorders and diagnostics(21)

Publications224 total

Comparison with Ezh2 reveals the PRC2-dependent functions of Jarid2 in hematopoietic stem Cell lineage commitment
Stem Cell Reports·2026Open Access
MLL3 and MLL4 sustain hematopoietic stem cell multipotency by opposing a B-cell default state
2025Open Access
Parallel Evolution of Leukemic Clones in Myeloproliferative Neoplasms
2025Open Access
High expression of GFP on hematopoietic stem cells acts as a neoantigen triggering increased T cell-mediated clearance and reduced self-renewal
Blood·2025Open Access
Interleukin-12 and TNFα signaling drives parallel evolution of independent leukemic clones in JAK2V617F mutant myeloproliferative neoplasms
Blood·2025Open Access
<i>JAK2</i> <sup>V617F</sup> Myeloproliferative Neoplasms Support Parallel Evolution of Independent Leukemic Clones
2025Open Access
JARID2 Inhibition Reprograms Human Hematopoietic Progenitor Cells To Enhance Bone Marrow Transplantation
2025Open Access
Functional Comparison to Ezh2 Reveals PRC2-Independent Functions of Jarid2 in Hematopoietic Stem Cell Lineage Commitment
2025Open Access
Non-canonical functions of DNMT3A in hematopoietic stem cells regulate telomerase activity and genome integrity
Cell stem cell·2025· 4 citedOpen Access
Cell-extrinsic factors contribute toward myeloid-biased expansion in Tet2-mutant clonal hematopoiesis
Experimental Hematology·2025· 1 cited
Abstract 1916: Oncogenic fusion detection for leukemia patients using droplet digital PCR
Cancer Research·2025
Elevated mitochondrial membrane potential is a therapeutic vulnerability in Dnmt3a-mutant clonal hematopoiesis
Nature Communications·2025· 13 citedOpen Access
Stathmin 1 regulates mitophagy and cellular function in hematopoietic stem cells
2025· 2 citedOpen Access
RSK1 is an exploitable dependency in myeloproliferative neoplasms and secondary acute myeloid leukemia
Nature Communications·2025· 10 citedOpen Access
RSK1 dependency in FLT3-ITD acute myeloid leukemia
Blood Cancer Journal·2024· 6 citedOpen Access
EZH2-Mediated Methylation Regulates JARID2 Protein Stability in Normal and Neoplastic Hematopoiesis
Blood·2024
Dnmt3a Controls Hematopoietic Stem Cells Via DNA Methylation-Independent Regulation of Telomeres
Blood·2024· 1 citedOpen Access
<i>JAK2V617F</i> Mutant MPN Cells Support Parallel Evolution of Independent Leukemic Clones
Blood·2024
<i>In Vivo</i> and <i>Ex Vivo</i> Expansion of Functional Human Repopulating Cells through JARID2 Inhibition
Blood·2024
Loss of Microtubule Protein Stathmin-1 Impairs Autophagy in Hematopoietic Stem Cells
Blood·2024
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Frequent Co-authors

Margaret A. Goodell(16), Hamza Celik(12), Elizabeth L. Ostrander(9), Mira Jeong(8), Cates Mallaney(7), Ashley C. Kramer(7), Blanca Rodríguez(6), Andrew Martens(6), Min Luo(5), Wei Li(5), Liubin Yang(5), Melissa H. Little(4), Allison Mayle(4), Katherine Y. King(4), Won Kyun Koh(4), Gretchen J. Darlington(3), Lucy A. Godley(3), Xiaotian Zhang(3), Sang-Bae Kim(3), Berthold Göttgens(3)