Tien‐Sheng Tseng

National Chung Hsing University — Taiwan

Biochemistry, Genetics and Molecular Biology · Life Sciences

10h-index462citations33works1.82yr avg
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Research Topics

Bacterial biofilms and quorum sensing(5), Biochemical and Structural Characterization(5), Antimicrobial Peptides and Activities(4), melanin and skin pigmentation(4), Biochemical Analysis and Sensing Techniques(4)

Publications33 total

Pharmacophore‐Based Identification and Molecular Characterization of Potent Neprilysin Inhibitors: Biochemical and Therapeutic Implications for Cardiovascular Diseases
Chemical Biology & Drug Design·2026Open Access
NeuproGemp, a polyphenol-rich botanical formula, ameliorates Alzheimer’s-like pathology in APP/PS1 mice via inhibition of human glutaminyl cyclase
Frontiers in Pharmacology·2025Open Access
Discovery and characterization of novel hematopoietic prostaglandin D synthase inhibitors from traditional Chinese medicine: the bioactive potential of dihydroberberine in treatments of Duchenne muscular dystrophy and inflammation-related diseases
Journal of Enzyme Inhibition and Medicinal Chemistry·2025Open Access
The therapeutic potential of (R)-carvedilol in Huntington's disease through enhancement of autophagy-lysosomal pathway via GSK-3β inhibition
Neurotherapeutics·2025· 2 citedOpen Access
A novel Diguanylate cyclase VdcR has multifaceted regulatory functions in the pathogenicity of Vibrio vulnificus
Journal of Microbiology Immunology and Infection·2024· 2 citedOpen Access
Combatting Antibiotic-Resistant <i>Staphylococcus aureus</i>: Discovery of TST1N-224, a Potent Inhibitor Targeting Response Regulator VraRC, through Pharmacophore-Based Screening and Molecular Characterizations
Journal of Chemical Information and Modeling·2024· 2 citedOpen Access
Structure-guided identification and characterization of potent inhibitors targeting PhoP and MtrA to combat mycobacteria
Computational and Structural Biotechnology Journal·2024· 4 citedOpen Access
Discovery of a potent inhibitor, D-132, targeting AsfvPolX, via protein-DNA complex‐guided pharmacophore screening and in vitro molecular characterizations
Virus Research·2024· 1 citedOpen Access
Structure-Guided Discovery of PD-1/PD-L1 Interaction Inhibitors: Peptide Design, Screening, and Optimization via Computation-Aided Phage Display Engineering
Journal of Chemical Information and Modeling·2024· 5 cited
Development of anti-aflatoxin B1 nanobodies from a novel mutagenesis-derived synthetic library for traditional Chinese medicine and foods safety testing
Journal of Biological Engineering·2023· 15 citedOpen Access
The deficiency of poly-β-1,6-N-acetyl-glucosamine deacetylase trigger A. baumannii to convert to biofilm-independent colistin-tolerant cells
Scientific Reports·2023· 11 citedOpen Access
Deciphering Structure-Function Relationship Unveils Salt-Resistant Mode of Action of a Potent MRSA-Inhibiting Antimicrobial Peptide, RR14
Journal of Bacteriology·2022· 1 citedOpen Access
Structural insights into <scp>DNA</scp> binding domain of vancomycin‐resistance‐associated response regulator in complex with its promoter <scp>DNA</scp> from <i>Staphylococcus aureus</i>
Protein Science·2022· 5 citedOpen Access
Antigen–Antibody Complex-Guided Exploration of the Hotspots Conferring the Immune-Escaping Ability of the SARS-CoV-2 RBD
Frontiers in Molecular Biosciences·2022· 9 citedOpen Access
Correction: Discovery of 8-prenylnaringenin from hop (<i>Humulus lupulus</i> L.) as a potent monoacylglycerol lipase inhibitor for treatments of neuroinflammation and Alzheimer’s disease
RSC Advances·2022· 2 citedOpen Access
Pharmacophore-driven identification of human glutaminyl cyclase inhibitors from foods, plants and herbs unveils the bioactive property and potential of Azaleatin in the treatment of Alzheimer's disease
Food & Function·2022· 8 cited
Discovery of 8-prenylnaringenin from hop (<i>Humulus lupulus</i>L.) as a potent monoacylglycerol lipase inhibitor for treatments of neuroinflammation and Alzheimer's disease
RSC Advances·2021· 15 citedOpen Access
Characterizing the structure–activity relationships of natural products, tanshinones, reveals their mode of action in inhibiting spleen tyrosine kinase
RSC Advances·2021· 8 citedOpen Access
Characterization of the structure–function relationship of a novel salt-resistant antimicrobial peptide, RR12
RSC Advances·2020· 12 citedOpen Access
Exploring the mode of action of inhibitors targeting the PhoP response regulator of<i>Salmonella enterica</i>through comprehensive pharmacophore approaches
RSC Advances·2019· 4 citedOpen Access
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Frequent Co-authors

Keng‐Chang Tsai(16), Kit-Man Fung(8), Shu-Jung Lai(6), Wang-Chuan Chen(5), Chinpan Chen(5), Nai‐Wan Hsiao(4), Yu‐Ching Lee(4), Yu‐Ching Lee(4), Min‐Che Tung(4), Yichen Wu(3), Wang-Chuan Chen(2), Hui-Hsiung Lin(2), Hui-Hsiung Lin(2), Yeng‐Tseng Wang(2), Hung-Ju Hsu(2), Ming‐Jaw Don(2), I‐Fan Tu(2), Shih‐Hsiung Wu(2), Nai-Wan Hsiao(2), Chao‐Sheng Cheng(2)