Leonard G. Meggs

Ochsner Health System — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

28h-index3.8kcitations68works0.02yr avg
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Research Topics

Receptor Mechanisms and Signaling(13), Cardiovascular Function and Risk Factors(9), Adipose Tissue and Metabolism(9), Cardiomyopathy and Myosin Studies(7), Renin-Angiotensin System Studies(7)

Publications68 total

Aging phenotype(s) in kidneys of diabetic mice are p66ShcA dependent
American Journal of Physiology-Renal Physiology·2018· 9 cited
Modulation of apolipoprotein L1-microRNA-193a axis prevents podocyte dedifferentiation in high-glucose milieu
American Journal of Physiology-Renal Physiology·2018· 31 citedOpen Access
AT<sub>1</sub>R blockade in adverse milieus: role of SMRT and corepressor complexes
American Journal of Physiology-Renal Physiology·2015· 7 citedOpen Access
Polycyclic aromatic hydrocarbons—induced ROS accumulation enhances mutagenic potential of T‐antigen from human polyomavirus JC
Journal of Cellular Physiology·2013· 47 citedOpen Access
Deficit of p66ShcA restores redox-sensitive stress response program in cisplatin-induced acute kidney injury
Experimental and Molecular Pathology·2013· 8 citedOpen Access
Diabetic nephropathy: lessons from the mouse.
PubMed·2013· 8 citedOpen Access
Null mutations at the p66 and bradykinin 2 receptor loci induce divergent phenotypes in the diabetic kidney
American Journal of Physiology-Renal Physiology·2012· 13 citedOpen Access
Receptor Loci Induce Divergent Phenotypes in
2012
HIV gene expression deactivates redox-sensitive stress response program in mouse tubular cells both in vitro and in vivo
American Journal of Physiology-Renal Physiology·2011· 14 citedOpen Access
Cardiorenal Protection in Diabetes Mellitus
2011
Insulin‐like growth factor‐I–forkhead box O transcription factor 3a counteracts high glucose/tumor necrosis factor‐α‐mediated neuronal damage: Implications for human immunodeficiency virus encephalitis
Journal of Neuroscience Research·2010· 30 citedOpen Access
Inhibition of p66ShcA Longevity Gene Rescues Podocytes from HIV-1-induced Oxidative Stress and Apoptosis
Journal of Biological Chemistry·2009· 48 citedOpen Access
Inhibition of p66ShcA redox activity in cardiac muscle cells attenuates hyperglycemia-induced oxidative stress and apoptosis
American Journal of Physiology-Heart and Circulatory Physiology·2008· 35 citedOpen Access
Abstract 1390: Enhanced Leptin Expression in the Hypothalamus Reverses p66ShcA Dependent Oxidative Stress and Myocyte Apoptosis in Akita Mice
Circulation·2008
Overexpression of G<sub>s</sub>α compensates for myocyte loss in diabetic cardiomyopathyPresented in part at the American Heart Association meeting, New Orleans, Louisiana, November 2004.
Canadian Journal of Physiology and Pharmacology·2008· 3 cited
Abstract 221: Inhibition Of Wild Type P66shca In Cardiac Myocytes Prevents Hyperglycemia Induced Oxidative Stress And Promotes The Survival Phenotype
Circulation·2007
Abstract 940: C-kit Positive Cardiac Progenitor Cells Contribute to the Embryonic Development of the Heart
Circulation·2007· 1 cited
Inhibition of wild-type p66ShcA in mesangial cells prevents glycooxidant-dependent FOXO3a regulation and promotes the survival phenotype
American Journal of Physiology-Renal Physiology·2006· 28 cited
Activated IGF-1R inhibits hyperglycemia-induced DNA damage and promotes DNA repair by homologous recombination
American Journal of Physiology-Renal Physiology·2005· 68 cited
PKC-ε-dependent survival signals in diabetic hearts
American Journal of Physiology-Heart and Circulatory Physiology·2005· 39 cited
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Frequent Co-authors

Ashwani Malhotra(20), Piero Anversa(15), Krzysztof Reiss(13), J. M. Capasso(12), Himanshu Vashistha(9), Norman K. Hollenberg(7), Pravin C. Singhal(7), Wei Cheng(6), Barinder Kang(6), Edmund H. Sonnenblick(5), Hui‐Fu Huang(5), P. Li(5), Jan Kajstura(4), Mohammad Husain(4), Moin A. Saleem(4), G Olivetti(3), David Opawumi(3), Richard W. Katzberg(3), Shuo Yang(3), Dileep Kumar(3)