Hidefumi Fukushima

Biochemistry, Genetics and Molecular Biology · Life Sciences

32h-index3.6kcitations68works0.02yr avg
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Research Topics

Bone Metabolism and Diseases(33), Ubiquitin and proteasome pathways(21), Bone health and treatments(18), NF-κB Signaling Pathways(11), TGF-β signaling in diseases(10)

Publications68 total

Correction: SCFβ-TRCP suppresses angiogenesis and thyroid cancer cell migration by promoting ubiquitination and destruction of VEGF receptor 2
The Journal of Experimental Medicine·2025Open Access
SCFFbw7 Modulates the NFκB Signaling Pathway by Targeting NFκB2 for Ubiquitination and Destruction
Cell Reports·2025Open Access
NOTCH2 Hajdu-Cheney Mutations Escape SCFFBW7-Dependent Proteolysis to Promote Osteoporosis
Molecular Cell·2017· 42 citedOpen Access
The SCF <sup>β-TRCP</sup> E3 ubiquitin ligase complex targets Lipin1 for ubiquitination and degradation to promote hepatic lipogenesis
Science Signaling·2017· 54 cited
Nutrient-induced FNIP degradation by SCFβ-TRCP regulates FLCN complex localization and promotes renal cancer progression
Oncotarget·2016· 17 citedOpen Access
Proteasome-dependent FNIP2 degradation modulates function of Birt-Hogg-Dube (BHD) complex
The Molecular Biology Society of Japan·2016
Analysis of proteasome-dependent lipogenic pathway in hepatocytes
The Molecular Biology Society of Japan·2016
Fine-tuning between BMP and NF-κB pathways regulates osteoblastic bone formation
Journal of Oral Biosciences·2016· 2 cited
[NF-κB signaling pathways and the future perspectives of bone disease therapy using selective inhibitors of NF-κB].
PubMed·2016· 11 cited
Functional Analysis of TRPM7 in Odontoblasts
The Journal of Physiological Sciences·2016Open Access
Inhibition of bone morphogenetic protein-induced osteoblast differentiation
Journal of Oral Biosciences·2015· 4 cited
The novel IκB kinase β inhibitor IMD-0560 prevents bone invasion by oral squamous cell carcinoma
Oncotarget·2014· 16 citedOpen Access
The role of nuclear factor-κB signaling in bone formation: One bite provides dual tastes
Journal of Oral Biosciences·2014· 2 cited
Inhibition of BMP2-Induced Bone Formation by the p65 Subunit of NF-κB via an Interaction With Smad4
Molecular Endocrinology·2014· 44 citedOpen Access
SCFβ-TRCP regulates osteoclastogenesis via promoting CYLD ubiquitination
Oncotarget·2014· 24 citedOpen Access
RelB-induced Expression of Cot, an MAP3K Family Member, Rescues RANKL-induced Osteoclastogenesis in Alymphoplasia Mice by Promoting NF-κB2 Processing by IKKα
Journal of Biological Chemistry·2014· 16 citedOpen Access
SCF-Mediated Cdh1 Degradation Defines a Negative Feedback System that Coordinates Cell-Cycle Progression
Cell Reports·2013· 77 citedOpen Access
Regulation of APCCdh1 E3 ligase activity by the Fbw7/cyclin E signaling axis contributes to the tumor suppressor function of Fbw7
Cell Research·2013· 29 citedOpen Access
p130Cas, Crk-Associated Substrate, Plays Important Roles in Osteoclastic Bone Resorption
Journal of Bone and Mineral Research·2013· 46 cited
Disruption of NF-κB1 prevents bone loss caused by mechanical unloading
Journal of Bone and Mineral Research·2013· 41 citedOpen Access
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Frequent Co-authors

Eijiro Jimi(24), Hiroyuki Inuzuka(19), Wenyi Wei(19), Koji Okabe(17), Lixin Wan(13), Daming Gao(11), Hiroshi Kajiya(10), Fujio Okamoto(9), Pengda Liu(9), Shavali Shaik(9), Zhiwei Wang(8), Kazuhiro Aoki(7), Keiichi Ohya(7), Masashi Shin(7), Alan W. Lau(6), Kenji Osawa(6), Hisataka Yasuda(6), Takahiro Doi(5), Kenshi Maki(5), Keiko Nakayama(4)