Pascal Notin

Harvard University — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

12h-index1.8kcitations40works15.92yr avg
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Research Topics

Genomics and Phylogenetic Studies(9), RNA and protein synthesis mechanisms(9), Machine Learning in Bioinformatics(7), Protein Structure and Dynamics(6), SARS-CoV-2 and COVID-19 Research(4)

Publications39 total

Few-shot Protein Fitness Prediction via In-context Learning and Test-time Training
arXiv (Cornell University)·2025Open Access
Democratizing protein language model training, sharing and collaboration
Nature Biotechnology·2025· 1 cited
Sampling Protein Language Models for Functional Protein Design
2025· 1 citedOpen Access
AI expands the repertoire of CRISPR-associated proteins for genome editing
Nature·2025· 2 cited
RNAGym: Large-scale Benchmarks for RNA Fitness and Structure Prediction
2025· 2 cited
Evolutionary-scale enzymology enables exploration of a rugged catalytic landscape
Science·2025· 12 citedOpen Access
Protriever: End-to-End Differentiable Protein Homology Search for Fitness Prediction
arXiv (Cornell University)·2025Open Access
Computationally designed proteins mimic antibody immune evasion in viral evolution
Immunity·2025· 8 citedOpen Access
Large-scale discovery, analysis, and design of protein energy landscapes
2025· 11 citedOpen Access
Epigenomic insights into extreme longevity in the world’s oldest terrestrial animal, Jonathan
2025Open Access
Multi-megabase scale genome interpretation with genetic language models
ArXiv.org·2025· 1 citedOpen Access
A Genomic Language Model for Zero-Shot Prediction of Promoter Variant Effects
2024· 2 citedOpen Access
Evolutionary-Scale Enzymology Enables Biochemical Constant Prediction Across a Multi-Peaked Catalytic Landscape
2024· 5 citedOpen Access
Machine learning for functional protein design
Nature Biotechnology·2024· 206 cited
Multi-Scale Representation Learning for Protein Fitness Prediction
2024· 2 citedOpen Access
ProteinGym: Large-Scale Benchmarks for Protein Design and Fitness Prediction
2023· 188 citedOpen Access
DiscoBAX: Discovery of Optimal Intervention Sets in Genomic Experiment Design
arXiv (Cornell University)·2023· 3 citedOpen Access
ProteinNPT: Improving Protein Property Prediction and Design with Non-Parametric Transformers
2023· 21 citedOpen Access
DiscoBAX_GeneDisco_datasets
Zenodo (CERN European Organization for Nuclear Research)·2023Open Access
DiscoBAX_GeneDisco_datasets
Zenodo (CERN European Organization for Nuclear Research)·2023Open Access
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Frequent Co-authors

Debora S. Marks(21), Yarin Gal(20), Jonathan Frazer(6), Aidan N. Gomez(6), Aaron W. Kollasch(6), Kelly P. Brock(5), Sarah F. Gurev(5), Mafalda Dias(4), Nicole N. Thadani(4), Noor Youssef(4), Arash Mehrjou(4), Patrick Schwab(4), Nathan Rollins(3), Chris Sander(3), Daniel P. Ritter(3), Lood van Niekerk(3), Joseph Min(2), Hansen Spinner(2), Ruben Weitzman(2), Mafalda Dias(2)