Amelie Lier

Heidelberg University — Germany

Biochemistry, Genetics and Molecular Biology · Life Sciences

15h-index2.6kcitations26works0.02yr avg
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Research Topics

Epigenetics and DNA Methylation(7), DNA Repair Mechanisms(6), Acute Myeloid Leukemia Research(6), Cancer Genomics and Diagnostics(6), Genetic factors in colorectal cancer(5)

Publications26 total

Combined targeted DNA and RNA sequencing of advanced NSCLC in routine molecular diagnostics: Analysis of the first 3,000 Heidelberg cases
International Journal of Cancer·2019· 100 citedOpen Access
Measurement of tumor mutational burden (TMB) in routine molecular diagnostics: <i>in silico</i> and real‐life analysis of three larger gene panels
International Journal of Cancer·2018· 110 citedOpen Access
Implementing tumor mutational burden (TMB) analysis in routine diagnostics—a primer for molecular pathologists and clinicians
Translational Lung Cancer Research·2018· 233 citedOpen Access
Validating Comprehensive Next-Generation Sequencing Results for Precision Oncology: The NCT/DKTK Molecularly Aided Stratification for Tumor Eradication Research Experience
JCO Precision Oncology·2018· 39 cited
Size matters: Dissecting key parameters for panel‐based tumor mutational burden analysis
International Journal of Cancer·2018· 156 cited
Targeted molecular profiling reveals genetic heterogeneity of poromas and porocarcinomas
Pathology·2017· 41 cited
Precision oncology based on omics data: The NCT Heidelberg experience
International Journal of Cancer·2017· 168 citedOpen Access
PD-L1 (CD274) copy number gain, expression, and immune cell infiltration as candidate predictors for response to immune checkpoint inhibitors in soft-tissue sarcoma
OncoImmunology·2017· 53 citedOpen Access
The Fanconi anemia pathway is required for efficient repair of stress-induced DNA damage in haematopoietic stem cells
Cell Cycle·2015· 22 citedOpen Access
OC-0624: Diffusion-weighted MRI for the prediction of response to neoadjuvant chemoradiotherapy in esophageal cancer
Radiotherapy and Oncology·2015
Exit from dormancy provokes DNA-damage-induced attrition in haematopoietic stem cells
Nature·2015· 607 cited
Identification of DNA methylation changes at <i>cis</i>-regulatory elements during early steps of HSC differentiation using tagmentation-based whole genome bisulfite sequencing
Figshare·2015Open Access
Identification of DNA methylation changes at <i>cis</i>-regulatory elements during early steps of HSC differentiation using tagmentation-based whole genome bisulfite sequencing
Figshare·2015Open Access
Altered HSC Metabolism in Response to Stress Leads to De Novo dna Damage and Cellular Attrition
Blood·2014
Identification of DNA methylation changes at<i>cis</i>-regulatory elements during early steps of HSC differentiation using tagmentation-based whole genome bisulfite sequencing
Cell Cycle·2014· 56 citedOpen Access
Identification of Regulatory Networks in HSCs and Their Immediate Progeny via Integrated Proteome, Transcriptome, and DNA Methylome Analysis
Cell stem cell·2014· 535 citedOpen Access
Whole-genome bisulfite sequencing of HSCs and their immediate progeny identifies novel regulatory elements involved in self-renewal and early hematopoietic commitment
Experimental Hematology·2014Open Access
Stress-induced exit from dormancy alters redox signaling in HSCs, resulting in de novo DNA damage and bone marrow failure in the absence of a functional fanconi anemia signaling pathway
Experimental Hematology·2014· 1 cited
Early aberrant DNA methylation events in a mouse model of acute myeloid leukemia
Genome Medicine·2014· 33 citedOpen Access
Myelodysplastic Cells in Patients Reprogram Mesenchymal Stromal Cells to Establish a Transplantable Stem Cell Niche Disease Unit
Cell stem cell·2014· 371 citedOpen Access
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Frequent Co-authors

Michael D. Milsom(13), Andreas Trumpp(12), David Brocks(10), Marieke Essers(10), Benedikt Brors(9), Volker Endris(8), Roland Penzel(8), Albrecht Stenzinger(8), Peter Schirmacher(8), Daniel B. Lipka(7), Dieter Weichenhan(7), Carl Herrmann(7), Roland Eils(7), Christoph Plass(7), Martina Kirchner(7), Stefan Fröhling(7), Dagmar Walter(6), Nina Cabezas‐Wallscheid(6), Daniel Klimmeck(6), Simon Haas(6)