Stephen D. Hauschka

University of Washington — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

66h-index14.4kcitations152works17.82yr avg
OpenAlex↗ORCID↗Google Scholar↗Lab page↗

Accepting Students?

No reports yet. Know if this professor is taking students?

Research Topics

Muscle Physiology and Disorders(90), Virus-based gene therapy research(31), Pluripotent Stem Cells Research(17), CRISPR and Genetic Engineering(17), Congenital heart defects research(15)

Publications152 total

13INV AAV delivery of mini- and full-length dystrophins
Neuromuscular Disorders·2024
Split intein-mediated protein trans-splicing to express large dystrophins
Nature·2024· 51 citedOpen Access
Assessment of systemic AAV-microdystrophin gene therapy in the GRMD model of Duchenne muscular dystrophy
UNC Libraries·2024Open Access
Targeted CRISPR activation is functional in engineered human pluripotent stem cells but undergoes silencing after differentiation into cardiomyocytes and endothelium
Cellular and Molecular Life Sciences·2024· 20 citedOpen Access
Split intein-mediated protein trans-splicing to express large dystrophins
2023· 5 citedOpen Access
WITHDRAWN: Cell based dATP delivery as a therapy for chronic heart failure
2023· 6 citedOpen Access
Assessment of systemic AAV-microdystrophin gene therapy in the GRMD model of Duchenne muscular dystrophy
Science Translational Medicine·2023· 64 citedOpen Access
Comparison of dystrophin expression following gene editing and gene replacement in an aged preclinical DMD animal model
Molecular Therapy·2022· 12 citedOpen Access
DeoxyATP producing hiPSC derived cardiomyocyte to restore cardiac function in heart failure
Biophysical Journal·2022
Laminin-111 Improves the Anabolic Response to Mechanical Load in Aged Skeletal Muscle
The Journals of Gerontology Series A·2020· 7 citedOpen Access
Dystrophin Gene-Editing Stability Is Dependent on Dystrophin Levels in Skeletal but Not Cardiac Muscles
Molecular Therapy·2020· 24 citedOpen Access
In Vivo Gene Editing of Muscle Stem Cells with Adeno-Associated Viral Vectors in a Mouse Model of Duchenne Muscular Dystrophy
Molecular Therapy — Methods & Clinical Development·2020· 53 citedOpen Access
Abstract 352: Optimization of a CRISPR Activation Human Pluripotent Stem Cell Line for Screening of Candidate Regulators of Cardiomyocyte Maturation
Circulation Research·2020
Gene Therapy Rescues Cardiac Dysfunction in Duchenne Muscular Dystrophy Mice by Elevating Cardiomyocyte Deoxy-Adenosine Triphosphate
JACC Basic to Translational Science·2019· 23 citedOpen Access
Development of Novel Micro-dystrophins with Enhanced Functionality
Molecular Therapy·2019· 110 citedOpen Access
Muscle-dominant wild-type TDP-43 expression induces myopathological changes featuring tubular aggregates and TDP-43-positive inclusions
Experimental Neurology·2018· 13 cited
AAV-Mediated Delivery of Ribonucleotide Reductase and Microdystrophin Rescues Function in Dystrophic Mice
Biophysical Journal·2018Open Access
Single-cut genome editing restores dystrophin expression in a new mouse model of muscular dystrophy
Science Translational Medicine·2017· 243 citedOpen Access
Correction: Corrigendum: Muscle-specific CRISPR/Cas9 dystrophin gene editing ameliorates pathophysiology in a mouse model for Duchenne muscular dystrophy
Nature Communications·2017· 138 citedOpen Access
Muscle-specific CRISPR/Cas9 dystrophin gene editing ameliorates pathophysiology in a mouse model for Duchenne muscular dystrophy
Nature Communications·2017· 379 citedOpen Access
page 1 of 8Next →

Frequent Co-authors

Jeffrey S. Chamberlain(9), Jean N. Buskin(8), Christopher H. Clegg(5), Bradley B. Olwin(4), Charles E. Murry(4), Thomas A. Linkhart(3), Niclas E. Bengtsson(3), Jane E. Johnson(3), Andrew B. Lassar(2), Harold Weintraub(2), John K. Hall(2), Guy L. Odom(2), Michael Phelps(2), Colin Andrus(2), R. David Hawkins(2), Joel R. Chamberlain(2), Hans Reinecke(2), James B. Jaynes(2), C L Gartside(2), Todd C. McDevitt(2)