John C. Murray

Materials Science · Physical Sciences

16h-index937citations41works1.52yr avg
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Research Topics

Crystallization and Solubility Studies(8), X-ray Diffraction in Crystallography(8), Computational Drug Discovery Methods(5), Antifungal resistance and susceptibility(4), Cholinesterase and Neurodegenerative Diseases(4)

Publications40 total

ACM TechBrief: Advancing Accessibility in the Digital World
ACM eBooks·2025Open Access
A General Synthesis of Dihydronaphthyridinones with Aryl-Substituted Quaternary Benzylic Centers
The Journal of Organic Chemistry·2023
Safety and nonclinical and clinical pharmacokinetics of PC945, a novel inhaled triazole antifungal agent
Pharmacology Research & Perspectives·2020· 63 citedOpen Access
Safety and nonclinical and clinical pharmacokinetics of PC945, a novel inhaled triazole antifungal agent
2020· 5 citedOpen Access
Current approaches to the discovery of novel inhaled medicines
Drug Discovery Today·2018· 61 citedOpen Access
Design and Synthesis of Clinical Candidate PF-06751979: A Potent, Brain Penetrant, β-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitor Lacking Hypopigmentation
Journal of Medicinal Chemistry·2018· 41 citedOpen Access
<i>In Vitro</i> and <i>In Vivo</i> Efficacy of a Novel and Long-Acting Fungicidal Azole, PC1244, on Aspergillus fumigatus Infection
Antimicrobial Agents and Chemotherapy·2018· 26 citedOpen Access
CCDC 1829109: Experimental Crystal Structure Determination
The Cambridge Structural Database·2018Open Access
Spiropiperidine Sultam and Lactam Templates: Diastereoselective Overman Rearrangement and Metathesis followed by NH Arylation
The Journal of Organic Chemistry·2017· 15 cited
<i>In Vitro</i> and <i>In Vivo</i> Antifungal Profile of a Novel and Long-Acting Inhaled Azole, PC945, on Aspergillus fumigatus Infection
Antimicrobial Agents and Chemotherapy·2017· 82 citedOpen Access
CCDC 1589529: Experimental Crystal Structure Determination
The Cambridge Structural Database·2017Open Access
CCDC 1484986: Experimental Crystal Structure Determination
The Cambridge Structural Database·2017Open Access
Autonomous services composition in domain 2
2016
Two Routes to 4-Fluorobenzisoxazol-3-one in the Synthesis of a 5-HT<sub>4</sub>Partial Agonist
Organic Process Research & Development·2016· 10 cited
CCDC 1485349: Experimental Crystal Structure Determination
The Cambridge Structural Database·2016Open Access
CCDC 1485348: Experimental Crystal Structure Determination
The Cambridge Structural Database·2016Open Access
Utilizing Structures of CYP2D6 and BACE1 Complexes To Reduce Risk of Drug–Drug Interactions with a Novel Series of Centrally Efficacious BACE1 Inhibitors
Journal of Medicinal Chemistry·2015· 78 citedOpen Access
2-Aryl-3-methyloctahydrophenanthrene-2,3,7-triols as Potent Dissociated Glucocorticoid Receptor Agonists
Journal of Medicinal Chemistry·2015· 5 citedOpen Access
Discovery of a Series of Efficient, Centrally Efficacious BACE1 Inhibitors through Structure-Based Drug Design
Journal of Medicinal Chemistry·2015· 45 citedOpen Access
CCDC 1052960: Experimental Crystal Structure Determination
The Cambridge Structural Database·2015Open Access
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Frequent Co-authors

Michael A. Brodney(15), Brian T. O’Neill(15), Kevin Ogilvie(13), Luis Martinez-Alsina(11), Leanne M. Buzon(10), Jason K. Dutra(10), Gabriela Barreiro(9), Charles E. Nolan(9), Erik LaChapelle(9), Ricardo Lira(9), Christopher R. Butler(8), David Riddell(8), Cathleen Gonzales(8), Ashley Robshaw(8), Shawn D. Doran(8), Subas M. Sakya(8), Elizabeth M. Beck(7), Bruce N. Rogers(7), Joseph M. Young(7), Kevin Parris(6)