Elena Marrocco

Telethon Institute Of Genetics And Medicine — Italy

Biochemistry, Genetics and Molecular Biology · Life Sciences

22h-index1.4kcitations49works0.82yr avg
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Research Topics

Retinal Development and Disorders(33), CRISPR and Genetic Engineering(14), Virus-based gene therapy research(11), RNA regulation and disease(8), interferon and immune responses(6)

Publications49 total

In vitro high-content screening reveals miR-429 as a protective molecule in photoreceptor degeneration
Molecular Therapy — Nucleic Acids·2024· 1 citedOpen Access
A DNA base-specific sequence interposed between CRX and NRL contributes to RHODOPSIN expression
Scientific Reports·2024Open Access
Combined intraocular and intravenous gene delivery for therapy of gyrate atrophy of the choroid and retina
Molecular Therapy·2024· 2 cited
MicroRNA-181a/b modulation as possible therapeutic strategy for Autosomal Dominant Optic Atrophy
Biochimica et Biophysica Acta (BBA) - Bioenergetics·2024
A DNA base-specific sequence interposed between CRX and NRL contributes to RHODOPSIN expression.
2023Open Access
Liver‐directed gene therapy for ornithine aminotransferase deficiency
EMBO Molecular Medicine·2023· 17 citedOpen Access
<scp>miR</scp> ‐181a/b downregulation: a mutation‐independent therapeutic approach for inherited retinal diseases
EMBO Molecular Medicine·2022· 25 citedOpen Access
Therapeutic homology-independent targeted integration in retina and liver
Nature Communications·2022· 42 citedOpen Access
Inclusion of a degron reduces levels of undesired inteins after AAV-mediated protein trans-splicing in the retina
Molecular Therapy — Methods & Clinical Development·2021· 23 citedOpen Access
Altered heparan sulfate metabolism during development triggers dopamine-dependent autistic-behaviours in models of lysosomal storage disorders
Nature Communications·2021· 31 citedOpen Access
Challenging Safety and Efficacy of Retinal Gene Therapies by Retinogenesis
International Journal of Molecular Sciences·2021· 5 citedOpen Access
Allele-specific editing ameliorates dominant retinitis pigmentosa in a transgenic mouse model
The American Journal of Human Genetics·2021· 47 citedOpen Access
α-synuclein overexpression in the retina leads to vision impairment and degeneration of dopaminergic amacrine cells
Scientific Reports·2020· 44 citedOpen Access
miR-181a/b downregulation: a possible gene-independent therapeutic approach for inherited retinal diseases
2020
Gene replacement therapy provides benefit in an adult mouse model of Leigh syndrome
Brain·2020· 41 citedOpen Access
Light‐responsive microRNA miR‐211 targets Ezrin to modulate lysosomal biogenesis and retinal cell clearance
The EMBO Journal·2020· 44 citedOpen Access
Retinal Degeneration in MPS-IIIA Mouse Model
Frontiers in Cell and Developmental Biology·2020· 19 citedOpen Access
Gene replacement therapy provides benefit in an adult mouse model of Leigh syndrome
2020· 2 citedOpen Access
AAV-miR-204 Protects from Retinal Degeneration by Attenuation of Microglia Activation and Photoreceptor Cell Death
Molecular Therapy — Nucleic Acids·2019· 44 citedOpen Access
α-synuclein in the retina leads to degeneration of dopamine amacrine cells impairing vision
2019· 2 citedOpen Access
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Frequent Co-authors

Enrico Maria Surace(37), Settimio Rossi(20), Alberto Auricchio(20), Francesca Simonelli(19), Maria Laura Bacci(15), Salvatore Botta(14), Carlo Gesualdo(13), Sandro Banfi(13), Martina Sofia(13), Mariangela Lupo(11), Nicola de Prisco(11), Mariateresa Pizzo(9), Mario Renda(9), Fabiola Curion(8), Alessia Indrieri(7), Carolina Iodice(6), Massimo Giunti(6), Michele Della Corte(6), Sara Barbato(6), Annamaria Carissimo(6)