Nicholas H. Simpson

University of Birmingham — United Kingdom

Biochemistry, Genetics and Molecular Biology · Life Sciences

4h-index350citations8works0.02yr avg
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Research Topics

Viral Infectious Diseases and Gene Expression in Insects(6), Cell death mechanisms and regulation(3), RNA Interference and Gene Delivery(3), Pluripotent Stem Cells Research(2), Protein Hydrolysis and Bioactive Peptides(2)

Publications8 total

Modulation of Apoptosis by BCL-2 Expression Following Amino Acid Deprivation and in High Cell Density Perfusion Cultures
Kluwer Academic Publishers eBooks·2006· 1 cited
Nutritional Performance of Wheat-Gluten-Derived Protein Hydrolysates in Hybridoma Cell Cultures. A Nutritional Function Study
2005
Metabolic Shifts in Hybridoma Cells Utilising Wheat Peptides
2001· 1 cited
Bcl-2 over-expression reduces growth rate and prolongs G1 phase in continuous chemostat cultures of hybridoma cells
Biotechnology and Bioengineering·1999· 78 cited
In hybridoma cultures, deprivation of any single amino acid leads to apoptotic death, which is suppressed by the expression of thebcl-2 gene
Biotechnology and Bioengineering·1998· 130 cited
Prevention of hybridoma cell death bybcl-2 during suboptimal culture conditions
Biotechnology and Bioengineering·1997· 132 cited
Prevention of hybridoma cell death by bcl2 during suboptimal culture conditions
Biotechnology and Bioengineering·1997· 7 cited
Overexpression of the apoptosis suppressor gene, bcl-2, in hybridoma cells prolongs viability and increases productivity in batch culture
1997· 1 cited

Frequent Co-authors

Mohamed Al‐Rubeai(6), Rabinder Singh(3), Anne E. Milner(2), A. Perani(2), C. Goldenzon(2), H.B.A. Wegkamp(2), André D. Siemensma(2), Dirk E. Martens(2), Katherine A. Kentistou(1), Ben A. Bulthuis(1), D. Fassnacht(1), Ralf Pörtner(1), Hans H. Huttinga(1), Ton Kunst(1)