Edgars Liepinsh

Latvijas Organiskās Sintēzes Institūts — LV

Biochemistry, Genetics and Molecular Biology · Life Sciences

38h-index5.2kcitations284works5.22yr avg
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Research Topics

Metabolism and Genetic Disorders(56), Crystallization and Solubility Studies(47), X-ray Diffraction in Crystallography(47), Metabolomics and Mass Spectrometry Studies(32), Mitochondrial Function and Pathology(27)

Publications278 total

Short-term changes in des-acyl ghrelin following bariatric surgery
Endocrine Connections·2025Open Access
Low Bioavailability and High TMAO Production: Novel Insights Into Acetylcarnitine and Carnitine Metabolism
Molecular Nutrition & Food Research·2025Open Access
Testing Strategies for Metabolite-Mediated Neurotoxicity
International Journal of Molecular Sciences·2025Open Access
LC–MS/MS-based simultaneous quantification of acylcarnitines, eicosapentaenoic acid, and docosahexaenoic acid: exploring potential biomarkers in human plasma
Analytical and Bioanalytical Chemistry·2025· 2 citedOpen Access
Plasma Protein Binding (PPB) Results for Multiple Compounds
2025
Multiple compound stability in liver microsomes (RISK-HUNT3R part 1)
2025
<scp>EPA</scp> and <scp>DHA</scp> acylcarnitines are less cardiotoxic than are saturated and monounsaturated long‐chain acylcarnitines
BioFactors·2025· 4 citedOpen Access
PK/PD modelling and simulation of longitudinal meropenem in vivo effects against Escherichia coli and Klebsiella pneumoniae strains with high MICs
International Journal of Antimicrobial Agents·2024· 1 citedOpen Access
Model-informed drug development for antimicrobials: translational pharmacokinetic-pharmacodynamic modelling of apramycin to facilitate prediction of efficacious dose in complicated urinary tract infections
Journal of Antimicrobial Chemotherapy·2024· 2 citedOpen Access
Fatty acid β-oxidation in brain mitochondria: Insights from high-resolution respirometry in mouse, rat and Drosophila brain, ischemia and aging models
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease·2024· 5 citedOpen Access
Short term changes in des-acyl ghrelin following bariatric surgery
Clinical Nutrition ESPEN·2024
High-resolution respirometry for measurement of fatty acid β-oxidation in brain mitochondria. A comparative study and application in ischemia and aging
Biochimica et Biophysica Acta (BBA) - Bioenergetics·2024
Off‐target effects of statins: molecular mechanisms, side effects and the emerging role of kinases
British Journal of Pharmacology·2024· 26 citedOpen Access
Development of Potent Microtubule Targeting Agent by Structural Simplification of Natural Diazonamide
Journal of Medicinal Chemistry·2024· 6 cited
Hydroxymethylglutaryl‐CoA reductase activity is essential for mitochondrial β‐oxidation of fatty acids to prevent lethal accumulation of long‐chain acylcarnitines in the mouse liver
British Journal of Pharmacology·2024· 11 citedOpen Access
Antibiotic class with potent in vivo activity targeting lipopolysaccharide synthesis in Gram-negative bacteria
Proceedings of the National Academy of Sciences·2024· 22 citedOpen Access
Innovative Approach to Enhance Bioavailability of Birch Bark Extracts: Novel Method of Oleogel Development Contrasted with Other Dispersed Systems
Plants·2024· 4 citedOpen Access
Conceptual foundations of acetylcarnitine supplementation in neuropsychiatric long COVID syndrome: a narrative review
European Archives of Psychiatry and Clinical Neuroscience·2024· 10 citedOpen Access
Decreased long-chain acylcarnitine content increases mitochondrial coupling efficiency and prevents ischemia-induced brain damage in rats
Biomedicine & Pharmacotherapy·2023· 6 citedOpen Access
Knockout of Tmlhe in mice is not associated with autism spectrum disorder phenotypes or motor dysfunction despite low carnitine levels
Molecular Autism·2023· 1 citedOpen Access
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Frequent Co-authors

Maija Dambrova(43), Janis Kuka(25), Marina Makrecka‐Kuka(23), Solveiga Grı̄nberga(21), Reinis Vilšķe̅rsts(15), Osvalds Pugovičs(15), Helena Cirule(14), Ivars Kalvinsh(13), Eduards Sevostjanovs(11), Baiba Švalbe(10), Elīna Makarova(9), Elina Skapare(8), Kristine Volska(7), Liga Zvejniece(7), Ilze Konrāde(6), Kārlis Vilks(5), U. Antone(5), Coert J. Zuurbier(4), Kaspars Tārs(4), Einārs Loža(4)