Kai Kessenbrock

University of California, Irvine — United States

Medicine · Health Sciences

37h-index16.9kcitations88works8.62yr avg
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Research Topics

Cancer Cells and Metastasis(26), Single-cell and spatial transcriptomics(25), Cancer Genomics and Diagnostics(11), Protease and Inhibitor Mechanisms(9), Immune Cell Function and Interaction(8)

Publications88 total

Single-cell profiling of synchronous multi-organ metastasis reveals a systemic CD74 <sup>+</sup> lipid-associated macrophage niche driving polymetastatic breast cancer
2026Open Access
Type 2 innate lymphoid cells fuel breast cancer development via direct interactions with cancer cells and by inhibiting anti-cancer immunity 4454
The Journal of Immunology·2025Open Access
Multi-organ transcriptomic and functional characterization of tumor-associated neutrophils in breast cancer 4374
The Journal of Immunology·2025Open Access
Assessment and enhancement of natural killer cell-mediated anti-tumor immunity in brain metastasis 4449
The Journal of Immunology·2025Open Access
Defining breast epithelial cell types in the single-cell era
Developmental Cell·2025· 4 citedOpen Access
PHLDA2 promotes breast cancer metastasis by co-opting a developmental program for placental vascular remodeling
2025Open Access
Sequential emergence and contraction of epithelial subtypes in the prenatal human choroid plexus revealed by a stem cell model
Nature Communications·2025· 2 citedOpen Access
IL-33/ST2 signaling in ILC2s drives exhaustion and myeloid skewing of HSCs in response to hematopoietic stress and aging
iScience·2025· 1 citedOpen Access
Circadian control of tumor immunosuppression affects efficacy of immune checkpoint blockade
Nature Immunology·2024· 68 citedOpen Access
Type 2 innate lymphoid cells fuel breast cancer development by inhibiting anti-cancer immunity
The Journal of Immunology·2024
Targeting tumor–stromal interactions in triple-negative breast cancer using a human vascularized micro-tumor model
Breast Cancer Research·2024· 20 citedOpen Access
Nuclear RNA catabolism controls endogenous retroviruses, gene expression asymmetry, and dedifferentiation
Molecular Cell·2023· 16 citedOpen Access
Targeting tumor-stromal interactions in triple-negative breast cancer using a human vascularized micro-tumor model
2023Open Access
Single-cell and spatial transcriptomics identify a macrophage population associated with skeletal muscle fibrosis
Science Advances·2023· 111 citedOpen Access
A spatially resolved single-cell genomic atlas of the adult human breast
Nature·2023· 211 citedOpen Access
The circadian clock CRY1 regulates pluripotent stem cell identity and somatic cell reprogramming
Cell Reports·2023· 13 citedOpen Access
Multiomic and spatial immunophenotyping reveals a prominent Runx3+ resident T cell population in the healthy human breast
The Journal of Immunology·2023· 1 citedOpen Access
A spatially resolved single cell genomic atlas of the adult human breast
2023· 25 citedOpen Access
Presentation of Human Neural Stem Cell Antigens Drives Regulatory T Cell Induction
The Journal of Immunology·2023· 3 citedOpen Access
Single-cell and spatial transcriptomics identify a macrophage population associated with skeletal muscle fibrosis
2023· 9 citedOpen Access
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Frequent Co-authors

Quy Nguyen(18), Zena Werb(13), Devon A. Lawson(13), Nicholas Pervolarakis(12), Kevin Nee(8), Dennis Ma(7), Hamad Alshetaiwi(7), Qing Nie(6), Peng Sun(6), Xing Dai(6), Morgan Dragan(5), Yanwen Gong(5), Michael Mähler(5), Marvin J. Fritzler(5), Dieter E. Jenne(4), Andrei Goga(4), Ryan T. Davis(4), Grace A. Hernandez(4), Kerrigan Blake(4), Robert A. Edwards(4)