Patricia A. Fraser

Brigham and Women's Hospital — United States

Immunology and Microbiology · Life Sciences

30h-index4.3kcitations86works7.52yr avg
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Research Topics

T-cell and B-cell Immunology(30), Systemic Lupus Erythematosus Research(24), Immune Cell Function and Interaction(15), Rheumatoid Arthritis Research and Therapies(11), Monoclonal and Polyclonal Antibodies Research(9)

Publications86 total

Phase 1/2 trial of the HPK1 inhibitor NDI-101150 as monotherapy and in combination with pembrolizumab: Clinical update.
Journal of Clinical Oncology·2024· 10 cited
Choosing to End African American Health Disparities in Patients With Systemic Lupus Erythematosus
Arthritis & Rheumatology·2024· 5 cited
751 Monotherapy results from an ongoing phase 1a dose escalation study of NDI-101150, a highly selective oral hematopoietic progenitor kinase 1 (HPK1) inhibitor
Regular and Young Investigator Award Abstracts·2023· 3 citedOpen Access
One-year results of a clinical trial of olipudase alfa enzyme replacement therapy in pediatric patients with acid sphingomyelinase deficiency
Genetics in Medicine·2022· 5 citedOpen Access
One-year results of a clinical trial of olipudase alfa enzyme replacement therapy in pediatric patients with acid sphingomyelinase deficiency
Genetics in Medicine·2021· 85 citedOpen Access
Children treated with olipudase alfa for chronic acid sphingomyelinase deficiency show meaningful improvement on clinically relevant outcomes and an overall favorable safety profile: 1-year results of the ASCEND-Peds trial
Molecular Genetics and Metabolism·2021
Adults with chronic acid sphingomyelinase deficiency show significant visceral, pulmonary, and hematologic improvements after enzyme replacement therapy with olipudase-alfa: 1-year results of the ASCEND placebo-controlled trial
Molecular Genetics and Metabolism·2021· 1 cited
P.69NEO1 and NEO-EXT studies: exploratory efficacy of repeat avalglucosidase alfa dosing for up to 5 years in participants with late-onset Pompe disease (LOPD)
Neuromuscular Disorders·2019
NEO1 AND NEO-EXT STUDIES: PHARMACODYNAMIC/EXPLORATORY BIOMARKER AND SAFETY ASSESSMENTS FOLLOWING REPEAT AVALGLUCOSIDASE ALFA DOSING FOR UP TO 4.5 YEARS IN PATIENTS WITH LATE-ONSET POMPE DISEASE
2019· 1 cited
Pesticide exposure and risk of systemic lupus erythematosus in an urban population of predominantly African-American women
Lupus·2018· 28 cited
Efficacy and Safety of Atacicept in Patients With Systemic Lupus Erythematosus
Arthritis & Rheumatology·2017· 225 citedOpen Access
8 Efficacy and safety of atacicept in patients with systemic lupus erythematosus: results of a 24-week randomisedrandomized, placebo-controlled, phase iib study
2017· 2 citedOpen Access
Designing an intervention for women with systemic lupus erythematosus from medically underserved areas to improve care: a qualitative study
Lupus·2012· 54 citedOpen Access
P93 The acceptability of routine enquiry of gender-based violence at sexual health clinics
Sexually Transmitted Infections·2012Open Access
MHC region and risk of systemic lupus erythematosus in African American women
Human Genetics·2011· 31 cited
Development and initial validation of a self‐assessed lupus organ damage instrument
Arthritis Care & Research·2010· 54 cited
A prospective study of androgen levels, hormone-related genes and risk of rheumatoid arthritis
Arthritis Research & Therapy·2009· 60 citedOpen Access
Meiotic recombination generates rich diversity in NK cell receptor genes, alleles, and haplotypes
Genome Research·2009· 124 citedOpen Access
Gene–environment interaction between HLA-DRB1 shared epitope and heavy cigarette smoking in predicting incident rheumatoid arthritis
Annals of the Rheumatic Diseases·2009· 228 citedOpen Access
HLA-DR Alpha 2 Mediates Negative Signalling via Binding to Tirc7 Leading to Anti-Inflammatory and Apoptotic Effects in Lymphocytes In Vitro and In Vivo
PLoS ONE·2008· 12 citedOpen Access
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Frequent Co-authors

Michael E. Weinblatt(9), Karen H. Costenbader(7), Edmond J. Yunis(5), David N. Glass(4), Jonathan S. Coblyn(4), Elizabeth W. Karlson(4), Glinda S. Cooper(4), Elizabeth W. Karlson(4), Peter H. Schur(4), Donald E. Holdsworth(3), David E. Trentham(3), Agnes L. Maier(3), Lori B. Chibnik(3), M. Elaine Husni(3), Matthew H. Liang(3), Helen Pankey(3), Dolores A. Fici(3), Elena Massarotti(3), Jean M. Jackson(3), Martin G. Larson(3)