Minoru Tada

National Institute of Health Sciences — Japan

Medicine · Health Sciences

23h-index2.1kcitations113works2.52yr avg
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Research Topics

Monoclonal and Polyclonal Antibodies Research(40), Glycosylation and Glycoproteins Research(20), Protein purification and stability(20), Barrier Structure and Function Studies(10), T-cell and B-cell Immunology(6)

Publications112 total

Linker and Conjugation Site Synergy in Antibody–Drug Conjugates: Impacts on Biological Activity
Bioconjugate Chemistry·2024· 4 citedOpen Access
Key role of Pro230 in the hinge region on the IgG architecture and function
2024· 1 citedOpen Access
Specific peptide conjugation to a therapeutic antibody leads to enhanced therapeutic potency and thermal stability by reduced Fc dynamics
Scientific Reports·2023· 9 citedOpen Access
Target-independent Immune-cell Activation by Aggregates of T Cell-redirecting Bispecific Antibodies
Journal of Pharmaceutical Sciences·2023· 3 cited
Characterization of anti-SARS-CoV-2 monoclonal antibodies focusing on antigen binding, neutralization, and FcγR activation via formation of immune complex
mAbs·2023· 5 citedOpen Access
FcγRIIIa-158V/F polymorphism affects the performance of FcγRIIIa-related bioassay
Biochemical and Biophysical Research Communications·2022· 3 cited
Fcγ Receptor-Dependent Internalization and Off-Target Cytotoxicity of Antibody-Drug Conjugate Aggregates
Pharmaceutical Research·2021· 66 citedOpen Access
The influence of antibody engineering on Fc conformation and Fc receptor binding properties: Analysis of FcRn-binding engineered antibodies and an Fc fusion protein
mAbs·2021· 16 citedOpen Access
Characterization of Aggregated Antibody-Silicone Oil Complexes: From Perspectives of Morphology, 3D Image, and Fcγ Receptor Activation
Journal of Pharmaceutical Sciences·2020· 15 citedOpen Access
Structural insight and stability of TNFR-Fc fusion protein (Etanercept) produced by using transgenic silkworms
The Journal of Biochemistry·2020· 7 citedOpen Access
Fcγ receptor activation by monoclonal antibody aggregates
The Pharmaceutical Society of Japan·2020
Development of anti-drug monoclonal antibody panels against adalimumab and infliximab
Biologicals·2019· 10 cited
Fcγ Receptor Activation by Human Monoclonal Antibody Aggregates
Journal of Pharmaceutical Sciences·2019· 29 citedOpen Access
Human-rat chimeric anti-occludin monoclonal antibodies inhibit hepatitis C virus infection
Biochemical and Biophysical Research Communications·2019· 6 cited
Effects of terminal galactose residues in mannose α1-6 arm of Fc-glycan on the effector functions of therapeutic monoclonal antibodies
mAbs·2019· 67 citedOpen Access
A Cell-Based Reporter Assay Measuring the Activation of Fc Gamma Receptors Induced by Therapeutic Monoclonal Antibodies
Methods in molecular biology·2018· 6 cited
Safety evaluation of a human chimeric monoclonal antibody that recognizes the extracellular loop domain of claudin-2
Toxicology Letters·2018
Effects of amino acid substitutions on the biological activity of anti-CD20 monoclonal antibody produced by transgenic silkworms (Bombyx mori)
Biochemical and Biophysical Research Communications·2018· 8 cited
Assessing the Heterogeneity of the Fc-Glycan of a Therapeutic Antibody Using an engineered FcγReceptor IIIa-Immobilized Column
Scientific Reports·2018· 62 citedOpen Access
Safety evaluation of a human chimeric monoclonal antibody that recognizes the extracellular loop domain of claudin-2
European Journal of Pharmaceutical Sciences·2018· 16 cited
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Frequent Co-authors

Akiko Ishii‐Watabe(24), Takuo Suzuki(12), Nana Kawasaki(6), Akihiro Watari(6), Kiyohito Yagi(6), Masuo Kondoh(6), Teruhide Yamaguchi(5), Kenji Kontani(5), Toshiaki Katada(5), Michihiko Aoyama(5), Noritaka Hashii(5), Manami Iida(5), Masayoshi Fukasawa(5), Yosuke Hashimoto(5), Terry A. Klein(4), José B. P. Lima(4), Akira Harazono(4), Masato Kiyoshi(4), Hiroko Shibata(4), Takuji Kishimoto(4)