Adrian M. Isaacs

Institute for Neurodegenerative Disorders — United States

Medicine · Health Sciences

52h-index14.6kcitations180works6.92yr avg
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Research Topics

Amyotrophic Lateral Sclerosis Research(98), Neurogenetic and Muscular Disorders Research(46), Alzheimer's disease research and treatments(45), Genetic Neurodegenerative Diseases(28), Parkinson's Disease Mechanisms and Treatments(20)

Publications180 total

Metformin promotes broad neuroprotection and proteostatic resilience via rngo/DDI2 stabilisation
2026Open Access
U7 small nuclear RNA splice-switching therapeutics for STMN2 and UNC13A in Amyotrophic Lateral Sclerosis
2025Open Access
CANVAS causing AAGGG repeat expansions cause tissue-specific reduction in RFC1 expression and increase sensitivity to DNA damage
2025Open Access
CRISPR/Cas9-mediated generation of a <i>de novo C9ORF72</i> knock-in isogenic iPSC cell bank to model ALS and FTD
2025Open Access
The Neurolipid Atlas: a lipidomics resource for neurodegenerative diseases
Nature Metabolism·2025· 9 citedOpen Access
An alternative cytoplasmic SFPQ isoform with reduced phase separation potential is up-regulated in ALS
Science Advances·2025· 2 citedOpen Access
Multi-modal comparative phenotyping of knock-in mouse models of frontotemporal dementia/amyotrophic lateral sclerosis
Disease Models & Mechanisms·2025· 3 citedOpen Access
Scalable human neuronal models of tauopathy producing endogenous seed-competent 4R tau
2025Open Access
CTAD taskforce: genetic therapies in Alzheimer’s disease
The Journal of Prevention of Alzheimer s Disease·2025· 3 citedOpen Access
<i>C9orf72</i> polyGA knock-in mice exhibit mild motor and proteomic changes consistent with ALS/FTD
2025Open Access
A multimodal screening platform for endogenous dipeptide repeat proteins in C9orf72 patient iPSC neurons
Cell Reports·2025· 1 citedOpen Access
Differential neuronal vulnerability to C9orf72 repeat expansion driven by Xbp1-induced endoplasmic reticulum-associated degradation
Cell Reports·2025· 3 citedOpen Access
Author Correction: Neuronal polyunsaturated fatty acids are protective in ALS/FTD
Nature Neuroscience·2025· 2 citedOpen Access
Neuronal polyunsaturated fatty acids are protective in ALS/FTD
Nature Neuroscience·2025· 21 citedOpen Access
Amyotrophic lateral sclerosis caused by hexanucleotide repeat expansions in C9orf72: from genetics to therapeutics
The Lancet Neurology·2025· 29 citedOpen Access
Generation of <i>C9orf72</i> repeat knock-in iPSC lines for modelling ALS and FTD
2025· 3 citedOpen Access
Generation of <i> C9orf72 <sup>h370</sup> </i> mice, an intron 1 humanised <i>C9orf72</i> repeat-expansion knock-in model
2025· 2 citedOpen Access
Dual-targeting CRISPR-CasRx reduces C9orf72 ALS/FTD sense and antisense repeat RNAs in vitro and in vivo
Nature Communications·2025· 16 citedOpen Access
The ALS- and FTD-associated proteins Annexin A11 and CHMP2B act sequentially in membrane repair
2024· 2 citedOpen Access
Molecular pathology, developmental changes and synaptic dysfunction in (pre-) symptomatic human C9ORF72-ALS/FTD cerebral organoids
Acta Neuropathologica Communications·2024· 12 citedOpen Access
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Frequent Co-authors

Elizabeth Fisher(14), Sarah Mizielinska(11), Pietro Fratta(11), Jonathan D. Rohrer(8), Jason D. Warren(8), Simon Mead(8), Linda Partridge(7), Martin N. Rossor(7), Tammaryn Lashley(7), John Collinge(7), John Hardy(6), Teresa Niccoli(6), Janice L. Holton(6), Ida E. Holm(6), Henry Houlden(5), Anny Devoy(5), Jon Beck(5), Nick C. Fox(5), Tamás Révész(5), Peter Johannsen(5)