Ladislav Bumba

Czech Academy of Sciences — Czech Republic

Immunology and Microbiology · Life Sciences

27h-index2.3kcitations82works1.52yr avg
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Research Topics

Bacterial Infections and Vaccines(30), Bacterial Genetics and Biotechnology(14), RNA and protein synthesis mechanisms(13), Photosynthetic Processes and Mechanisms(12), Lipid Membrane Structure and Behavior(11)

Publications82 total

Bacteria deliver a microtubule-binding protein into mammalian cells to promote colonization
Science·2026· 1 cited
Acyl chains stabilize the acylated domain and determine the receptor-mediated interaction of the Bordetella adenylate cyclase toxin with cell membrane
Journal of Biological Chemistry·2025· 1 citedOpen Access
Bacteria deliver a microtubule-binding protein into mammalian cells to promote colonization
2025· 1 citedOpen Access
The Actinobacillus pleuropneumoniae apxIV operon encodes an antibacterial toxin-immunity pair
Microbiological Research·2024· 3 citedOpen Access
The adenylate cyclase toxin RTX domain follows a series templated folding mechanism with implications for toxin activity
Journal of Biological Chemistry·2023· 14 citedOpen Access
A conserved tryptophan in the acylated segment of RTX toxins controls their β2 integrin–independent cell penetration
Journal of Biological Chemistry·2023· 3 citedOpen Access
BopN is a Gatekeeper of the <i>Bordetella</i> Type III Secretion System
Microbiology Spectrum·2023· 15 citedOpen Access
Advanced high-affinity glycoconjugate ligands of galectins
Bioorganic Chemistry·2022· 13 citedOpen Access
The AAA+ ATPase RavA and its binding partner ViaA modulate E. coli aminoglycoside sensitivity through interaction with the inner membrane
Nature Communications·2022· 9 citedOpen Access
Pertussis toxin suppresses dendritic cell-mediated delivery of B. pertussis into lung-draining lymph nodes
PLoS Pathogens·2022· 14 citedOpen Access
Glycopolymers Decorated with 3-<i>O</i>-Substituted Thiodigalactosides as Potent Multivalent Inhibitors of Galectin-3
Journal of Medicinal Chemistry·2022· 16 cited
The AAA+ ATPase RavA and its binding partner ViaA modulate <i>E. coli</i> aminoglycoside sensitivity through interaction with the inner membrane
2022Open Access
Different roles of conserved tyrosine residues of the acylated domains in folding and activity of RTX toxins
Scientific Reports·2021· 7 citedOpen Access
Almost half of the RTX domain is dispensable for complement receptor 3 binding and cell-invasive activity of the Bordetella adenylate cyclase toxin
Journal of Biological Chemistry·2021· 11 citedOpen Access
Immunoprotective neo-glycoproteins: Chemoenzymatic synthesis of multivalent glycomimetics for inhibition of cancer-related galectin-3
European Journal of Medicinal Chemistry·2021· 28 cited
Lipid binding by the N-terminal motif mediates plasma membrane localization of Bordetella effector protein BteA
Journal of Biological Chemistry·2021· 12 citedOpen Access
Acellular Pertussis Vaccine Inhibits Bordetella pertussis Clearance from the Nasal Mucosa of Mice
Vaccines·2020· 35 citedOpen Access
Lipid binding by N-terminal motif mediates plasma membrane localization of <i>Bordetella</i> effector protein BteA
2020Open Access
Production of Highly Active Recombinant Dermonecrotic Toxin of Bordetella Pertussis
Toxins·2020· 3 citedOpen Access
Continuous Assembly of β-Roll Structures Is Implicated in the Type I-Dependent Secretion of Large Repeat-in-Toxins (RTX) Proteins
Journal of Molecular Biology·2020· 26 cited
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Frequent Co-authors

Peter Šebo(21), Jiří Mašín(14), Radim Osička(10), František Vácha(10), Radovan Fišer(8), Vladimı́r Křen(8), Pavla Bojarová(8), Jana Kamanová(6), Adriana Osic̆ková(6), Helena Pelantová(6), Michaela Jirku(5), Jan Teisinger(5), Lucie Petrásková(5), Irena Linhartová(4), Lucie Bednářová(4), Václav Veverka(4), Lothar Elling(4), Tomáš Etrych(4), Petr Chytil(4), Ondřej Staněk(4)