J. Lesley Brown

National Institutes of Health — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

20h-index3.1kcitations30works10.02yr avg
OpenAlex↗ORCID↗Google Scholar↗Lab page↗

Accepting Students?

No reports yet. Know if this professor is taking students?

Research Topics

Genomics and Chromatin Dynamics(16), Epigenetics and DNA Methylation(16), Cancer-related gene regulation(7), Chromosomal and Genetic Variations(5), Protist diversity and phylogeny(5)

Publications30 total

Polycomb protein binding and looping in the ON transcriptional state
Science Advances·2024· 10 citedOpen Access
Polycomb protein binding and looping mediated by Polycomb Response Elements in the ON transcriptional state
2023· 1 citedOpen Access
Context-dependent role of Pho binding sites in Polycomb complex recruitment in Drosophila
Genetics·2023· 5 citedOpen Access
Crol contributes to PRE-mediated repression and Polycomb group proteins recruitment in<i>Drosophila</i>
Nucleic Acids Research·2023· 11 citedOpen Access
Global changes of H3K27me3 domains and Polycomb group protein distribution in the absence of recruiters Spps or Pho
Proceedings of the National Academy of Sciences·2018· 51 citedOpen Access
Architectural and Functional Diversity of Polycomb Group Response Elements in <i>Drosophila</i>
Genetics·2013· 32 citedOpen Access
Polycomb Group Response Elements in Drosophila and Vertebrates
Advances in genetics·2013· 226 citedOpen Access
Polycomb Group Proteins Bind an engrailed PRE in Both the “ON” and “OFF” Transcriptional States of engrailed
PLoS ONE·2012· 30 citedOpen Access
Spps, a<i>Drosophila</i>Sp1/KLF family member, binds to PREs and is required for PRE activity late in development
Development·2010· 46 citedOpen Access
Characterization of the Polycomb Group Response Elements of the <i>Drosophila melanogaster invected</i> Locus
Molecular and Cellular Biology·2009· 31 citedOpen Access
The role of Polycomb-group response elements in regulation of <i>engrailed</i> transcription in <i>Drosophila</i>
Development·2008· 50 cited
An Sp1/KLF binding site is important for the activity of a Polycomb group response element from the Drosophila engrailed gene
Nucleic Acids Research·2005· 85 citedOpen Access
Hierarchical Recruitment of Polycomb Group Silencing Complexes
Molecular Cell·2004· 566 citedOpen Access
The<i>Drosophila pho-like</i>gene encodes a YY1-related DNA binding protein that is redundant with<i>pleiohomeotic</i>in homeotic gene silencing
Development·2002· 190 citedOpen Access
Interactions of Protein Complexes on Supercoiled DNA: The Mechanism of Selective Synapsis by Tn3 Resolvase
Journal of Molecular Biology·2002· 8 cited
A Complex Array of DNA-Binding Proteins Required for Pairing-Sensitive Silencing by a Polycomb Group Response Element From the Drosophila <i>engrailed</i> Gene
Genetics·2002· 91 citedOpen Access
The DNA-binding Polycomb group protein Pleiohomeotic mediates silencing of a <i>Drosophila</i> homeotic gene
Development·1999· 181 cited
The Drosophila Polycomb Group Gene pleiohomeotic Encodes a DNA Binding Protein with Homology to the Transcription Factor YY1
Molecular Cell·1998· 403 citedOpen Access
Repression of Drosophila pair-rule segmentation genes by ectopic expression of tramtrackDevelopment 117, 45–58
Trends in Genetics·1993· 7 cited
Repression of <i>Drosophila</i> pair-rule segmentation genes by ectopic expression of <i>tramtrack</i>
Development·1993· 70 cited
page 1 of 2Next →

Frequent Co-authors

Judith A. Kassis(16), Ming-an Sun(4), Michael J. Siciliano(3), Richard Baer(3), Carl Wu(3), Martin R. Boocock(3), David J. Sherratt(3), Liangliang Zhang(3), Mary Whiteley(2), R Espinosa(2), Michelle M. Le Beau(2), Cornelia Fritsch(2), Hitoshi Ueda(2), Shunro Sonoda(2), Matthew P. Scott(2), Maksim Erokhin(2), Pedro P. Rocha(2), Liangjun Wang(1), Ru Cao(1), Yi Zhang(1)