Alan Melcher

Institute of Cancer Research — United Kingdom

Biochemistry, Genetics and Molecular Biology · Life Sciences

71h-index16.1kcitations544works1.62yr avg
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Research Topics

Virus-based gene therapy research(285), CAR-T cell therapy research(151), Cancer Research and Treatments(123), Immunotherapy and Immune Responses(111), Viral gastroenteritis research and epidemiology(91)

Publications541 total

Single versus repeated intravenous oncolytic reovirus infusions: Implications for immune modulation and rationalised scheduling of therapy in hepatocellular carcinoma
International Journal of Cancer·2026Open Access
Necroptosis in Both Tumour and Stromal Compartments Determines Responsiveness to Immunogenic Cell Death-based Immunotherapy
Zenodo (CERN European Organization for Nuclear Research)·2026Open Access
Necroptosis in Both Tumour and Stromal Compartments Determines Responsiveness to Immunogenic Cell Death-based Immunotherapy
Zenodo (CERN European Organization for Nuclear Research)·2026Open Access
Figure 4 from Xevinapant plus Chemoradiotherapy Negatively Sculpts the Tumor-Immune Microenvironment in Head and Neck Cancer
2025Open Access
Figure S4 from Xevinapant plus Chemoradiotherapy Negatively Sculpts the Tumor-Immune Microenvironment in Head and Neck Cancer
2025Open Access
Figure S6 from Xevinapant plus Chemoradiotherapy Negatively Sculpts the Tumor-Immune Microenvironment in Head and Neck Cancer
2025Open Access
Figure S7 from Xevinapant plus Chemoradiotherapy Negatively Sculpts the Tumor-Immune Microenvironment in Head and Neck Cancer
2025Open Access
Figure S5 from Xevinapant plus Chemoradiotherapy Negatively Sculpts the Tumor-Immune Microenvironment in Head and Neck Cancer
2025Open Access
Figure 3 from Xevinapant plus Chemoradiotherapy Negatively Sculpts the Tumor-Immune Microenvironment in Head and Neck Cancer
2025Open Access
Figure S1 from Xevinapant plus Chemoradiotherapy Negatively Sculpts the Tumor-Immune Microenvironment in Head and Neck Cancer
2025Open Access
Data from Xevinapant plus Chemoradiotherapy Negatively Sculpts the Tumor-Immune Microenvironment in Head and Neck Cancer
2025Open Access
Figure 2 from Xevinapant plus Chemoradiotherapy Negatively Sculpts the Tumor-Immune Microenvironment in Head and Neck Cancer
2025Open Access
Figure S3 from Xevinapant plus Chemoradiotherapy Negatively Sculpts the Tumor-Immune Microenvironment in Head and Neck Cancer
2025Open Access
Figure 1 from Xevinapant plus Chemoradiotherapy Negatively Sculpts the Tumor-Immune Microenvironment in Head and Neck Cancer
2025Open Access
Figure S2 from Xevinapant plus Chemoradiotherapy Negatively Sculpts the Tumor-Immune Microenvironment in Head and Neck Cancer
2025Open Access
Supplementary Data from Xevinapant plus Chemoradiotherapy Negatively Sculpts the Tumor-Immune Microenvironment in Head and Neck Cancer
2025Open Access
Engagement of the T cell receptor against an oncolytic virus generates a population of hypereffector CAR T cells with potent antitumor activity
2025Open Access
Beyond tumour mutational burden: Determinants of response to combination radiation/immunotherapy in Muscle-Invasive Bladder Cancer (MIBC)
European Urology Open Science·2025Open Access
896 Oncolytic vaccinia virus-mediated immunotherapy increases survival and reduces tumour growth by turning immunologically ‘cold’ oestrogen receptor-positive breast tumours ‘hot’
Regular and Young Investigator Award Abstracts·2025Open Access
Using oncolytic viruses to exploit endogenous TCR signaling for modulation of CAR T phenotype and function against solid tumors 4322
The Journal of Immunology·2025Open Access
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Frequent Co-authors

Kevin J. Harrington(38), Richard G. Vile(37), Hardev Pandha(26), Fiona Errington‐Mais(17), Peter J. Selby(16), Jill Thompson(12), Matt Coffey(12), Robin Prestwich(12), Timothy Kottke(11), Elizabeth J. Ilett(11), Rosa María Díaz(9), Katie Twigger(8), Karen J. Scott(6), Johann S. de Bono(6), Alison Merrick(5), Feorillo Galivo(5), Stephen Todryk(4), Matthew Coffey(4), Christine L. White(4), Victoria Roulstone(4)