Stephen C. Hyde

John Radcliffe Hospital — United Kingdom

Biochemistry, Genetics and Molecular Biology · Life Sciences

41h-index8.7kcitations244works3.52yr avg
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Research Topics

Virus-based gene therapy research(77), Cystic Fibrosis Research Advances(58), Neonatal Respiratory Health Research(51), RNA Interference and Gene Delivery(50), Viral gastroenteritis research and epidemiology(38)

Publications242 total

F/HN-pseudotyped lentiviral vector efficiently transduces non-human primate airways with no evidence of relevant toxicity
Molecular Therapy Advances·2025Open Access
Potential gene therapies for cystic fibrosis: a plain language summary for non-specialists and the lay community
Future Rare Diseases·2025
Single-cycle, pseudotyped reporter influenza virus to facilitate evaluation of treatment strategies for avian influenza, Ebola and other highly infectious diseases in vivo
Frontiers in Immunology·2025· 1 citedOpen Access
Lentiviral Gene Therapy for Cystic Fibrosis: A Promising Approach and First-in-Human Trial
American Journal of Respiratory and Critical Care Medicine·2024· 25 citedOpen Access
Pharmacological and pre-clinical safety profile of rSIV.F/HN, a hybrid lentiviral vector for cystic fibrosis gene therapy
European Respiratory Journal·2024· 2 citedOpen Access
P045 Lenticlair™ 1: A phase 1/2 trial evaluating the safety, tolerability and efficacy of an inhaled F/HN-pseudotyped lentiviral vector for CF gene therapy in people with CF ineligible for CFTR modulators
Journal of Cystic Fibrosis·2024
P046 Lenticlair™-ON: An extension trial examining long-term safety and efficacy outcomes associated with an inhaled F/HN-pseudotyped lentiviral vector for CF gene therapy in people with cystic fibrosis
Journal of Cystic Fibrosis·2024
WS10.01 Administration of lentiviral vector doses achieving high transduction efficiency is well tolerated in mice
Journal of Cystic Fibrosis·2024
WS17.06 F/HN pseudotyped lentiviral vector-mediated transduction of non-human primates
Journal of Cystic Fibrosis·2023· 1 citedOpen Access
Investigating religious commitment, perceived religious oppression, self-esteem, depression, and life satisfaction among Latter-day Saint women
Journal of Spirituality in Mental Health·2023· 5 cited
Type I interferon receptor signalling deficiency results in dysregulated innate immune responses to SARS‐CoV‐2 in mice
European Journal of Immunology·2022· 18 citedOpen Access
Author response for "Type I interferon signaling deficiency results in dysregulated innate immune responses to SARS‐CoV‐2 in mice"
2022
Progress in Respiratory Gene Therapy
Human Gene Therapy·2022· 24 citedOpen Access
Sendai F/HN pseudotyped lentiviral vector transduces human ciliated and non-ciliated airway cells using α 2,3 sialylated receptors
Molecular Therapy — Methods & Clinical Development·2022· 10 citedOpen Access
Intranasal Lentiviral Vector-Mediated Antibody Delivery Confers Reduction of SARS-CoV-2 Infection in Elderly and Immunocompromised Mice
Frontiers in Immunology·2022· 6 citedOpen Access
Correction of a chronic pulmonary disease through lentiviral vector-mediated protein expression
Molecular Therapy — Methods & Clinical Development·2022· 1 citedOpen Access
Lung directed antibody gene transfer confers protection against SARS-CoV-2 infection
Thorax·2022· 9 citedOpen Access
Aerosol-Mediated Non-Viral Lung Gene Therapy: The Potential of Aminoglycoside-Based Cationic Liposomes
Pharmaceutics·2021· 9 citedOpen Access
RNA-seq analysis of the human surfactant air-liquid interface culture reveals alveolar type II cell-like transcriptome
Molecular Therapy — Methods & Clinical Development·2021· 5 citedOpen Access
Genomic diversity of SARS-CoV-2 in Oxford during United Kingdom’s first national lockdown
Scientific Reports·2021· 7 citedOpen Access
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Frequent Co-authors

Deborah R. Gill(44), Eric W.F.W. Alton(19), Uta Griesenbach(16), David J. Porteous(15), Ian A. Pringle(12), Jane C. Davies(11), J. Alastair Innes(10), Gerry McLachlan(10), Stephanie Jones(10), Lee A. Davies(9), C. F. Higgins(8), Seng H. Cheng(8), Tracy Higgins(8), Alan Boyd(8), David Collie(7), Mario Chan(6), Christopher F. Higgins(5), Francisco V. Sepúlveda(5), William H Colledge(5), A. Christopher Boyd(5)