Jorge L. Del‐Aguila

Merck & Co., Inc., Rahway, NJ, USA (United States) — United States

Medicine · Health Sciences

28h-index4.7kcitations64works0.02yr avg
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Research Topics

Alzheimer's disease research and treatments(21), Bioinformatics and Genomic Networks(19), Neuroinflammation and Neurodegeneration Mechanisms(19), Genetic Associations and Epidemiology(18), Inflammation biomarkers and pathways(9)

Publications64 total

Single-nucleus RNA-sequencing of autosomal dominant Alzheimer disease and risk variant carriers
Nature Communications·2023· 79 citedOpen Access
A proteogenomic view of Parkinson’s disease causality and heterogeneity
npj Parkinson s Disease·2023· 51 citedOpen Access
MS4A4A modifies the risk of Alzheimer disease by regulating lipid metabolism and immune response in a unique microglia state
2023· 23 citedOpen Access
Parkinson’s disease causality and heterogeneity: a proteogenomic view
2022· 1 citedOpen Access
Parkinson’s disease causality and heterogeneity: a proteogenomic view
2022· 3 citedOpen Access
Multi-ancestry GWAS reveals excitotoxicity associated with outcome after ischaemic stroke
Brain·2022· 40 citedOpen Access
A landscape of the genetic and cellular heterogeneity in Alzheimer disease
2021· 11 citedOpen Access
<i>Chi3l1</i> /YKL-40 is controlled by the astrocyte circadian clock and regulates neuroinflammation and Alzheimer’s disease pathogenesis
Science Translational Medicine·2020· 212 citedOpen Access
Ascertaining perturbations in microglial expression profiles using single‐nuclei RNA‐seq from human brains
Alzheimer s & Dementia·2020Open Access
Multiomics approaches reveal a link between the <i>MS4A</i> gene loci, TREM2, and microglia function
Alzheimer s & Dementia·2020Open Access
Single‐nuclei RNA‐seq of brains carriers of high‐risk variants and Mendelian mutations
Alzheimer s & Dementia·2020· 1 citedOpen Access
Prediction of Alzheimer’s disease using plasma RNA sequences
Alzheimer s & Dementia·2020Open Access
Examination of the Effect of Rare Variants in <i>TREM2</i> , <i>ABI3</i> , and <i>PLCG2</i> in LOAD Through Multiple Phenotypes
Journal of Alzheimer s Disease·2020· 32 citedOpen Access
Genome‐wide association study of rate of cognitive decline in Alzheimer's disease patients identifies novel genes and pathways
Alzheimer s & Dementia·2020· 54 citedOpen Access
An atlas of cortical circular RNA expression in Alzheimer disease brains demonstrates clinical and pathological associations
Nature Neuroscience·2019· 362 citedOpen Access
The TMEM106B FTLD-protective variant, rs1990621, is also associated with increased neuronal proportion
Acta Neuropathologica·2019· 101 citedOpen Access
The <i>MS4A</i> gene cluster is a key modulator of soluble TREM2 and Alzheimer’s disease risk
Science Translational Medicine·2019· 268 citedOpen Access
A single-nuclei RNA sequencing study of Mendelian and sporadic AD in the human brain
Alzheimer s Research & Therapy·2019· 180 citedOpen Access
P4‐106: INTEGRATIVE ANALYSIS POINTS TO <i>AGFG2</i> AS A NOVEL PLAYER IN THE PATHOLOGY OF ALZHEIMER DISEASE
Alzheimer s & Dementia·2019
P1‐400: IMPACT OF REFERENCE REGION USED TO QUANTIFY AMYLOID BURDEN ON INTERPRETING THE RELATIONSHIP BETWEEN AMYLOID BURDEN AND GENETIC RISK FACTORS OF AD
Alzheimer s & Dementia·2019Open Access
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Frequent Co-authors

Carlos Cruchaga(40), John Budde(33), Oscar Harari(29), María Victoria Fernández(28), John C. Morris(21), Yuetiva Deming(21), Alison Goate(19), Laura Ibáñez(18), Kathleen Black(15), Bruno A. Benítez(14), Umber Dube(13), Zeran Li(13), Celeste M. Karch(11), David M. Holtzman(10), Joanne Norton(10), Anne M. Fagan(10), Sheng‐mei Ma(8), Sarah Bertelsen(7), Richard J. Perrin(7), Randall J. Bateman(7)