Prasanna Sivaprakasam

Chemistry · Physical Sciences

19h-index1.4kcitations42works3.32yr avg
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Research Topics

Synthesis and biological activity(12), Computational Drug Discovery Methods(9), HIV/AIDS drug development and treatment(8), Inflammatory mediators and NSAID effects(7), HIV Research and Treatment(6)

Publications42 total

Prevalence of hepatitis D among patients with hepatitis B: A cross-sectional study
Indian Journal of Gastroenterology·2025
Structure-Based Design of Novel TLR7/8 Agonist Payloads Enabling an Immunomodulatory Conjugate Approach
ACS Medicinal Chemistry Letters·2024· 3 citedOpen Access
Identification and Optimization of Small Molecule Pyrazolopyrimidine TLR7 Agonists for Applications in Immuno-oncology
ACS Medicinal Chemistry Letters·2024· 5 citedOpen Access
Discovery of Novel TLR7 Agonists as Systemic Agent for Combination With aPD1 for Use in Immuno-oncology
ACS Medicinal Chemistry Letters·2024· 5 citedOpen Access
Discovery of 2-(Anilino)pyrimidine-4-carboxamides as Highly Potent, Selective, and Orally Active Glycogen Synthase Kinase-3 (GSK-3) Inhibitors
Journal of Medicinal Chemistry·2023· 17 citedOpen Access
Design, Structure–Activity Relationships, and In Vivo Evaluation of Potent and Brain-Penetrant Imidazo[1,2-<i>b</i>]pyridazines as Glycogen Synthase Kinase-3β (GSK-3β) Inhibitors
Journal of Medicinal Chemistry·2023· 28 citedOpen Access
Scaffold modifications to the 4-(4,4-dimethylpiperidinyl) 2,6-dimethylpyridinyl class of HIV-1 allosteric integrase inhibitors
Bioorganic & Medicinal Chemistry·2022· 6 cited
Discovery and Preclinical Profiling of GSK3839919, a Potent HIV-1 Allosteric Integrase Inhibitor
ACS Medicinal Chemistry Letters·2022· 12 citedOpen Access
Design, Synthesis, and Preclinical Profiling of GSK3739936 (BMS-986180), an Allosteric Inhibitor of HIV-1 Integrase with Broad-Spectrum Activity toward 124/125 Polymorphs
Journal of Medicinal Chemistry·2022· 13 citedOpen Access
Synthesis, structure-activity relationship studies and evaluation of a TLR 3/8/9 agonist and its analogues
Medicinal Chemistry Research·2021· 1 citedOpen Access
DNA-Model-Based Design and Execution of Some Fused Benzodiazepine Hybrid Payloads for Antibody–Drug Conjugate Modality
ACS Medicinal Chemistry Letters·2021· 4 citedOpen Access
Design, Synthesis, and Structure–Activity Relationships of Novel Tetrahydroisoquinolino Benzodiazepine Dimer Antitumor Agents and Their Application in Antibody–Drug Conjugates
Journal of Medicinal Chemistry·2020· 15 cited
Structure-based amelioration of PXR transactivation in a novel series of macrocyclic allosteric inhibitors of HIV-1 integrase
Bioorganic & Medicinal Chemistry Letters·2020· 8 citedOpen Access
Synthesis, characterization, pharmacological evaluation and molecular docking studies of benzothiazole azo derivatives
Journal of Molecular Structure·2020· 39 cited
Discovery and Optimization of Novel Pyrazolopyrimidines as Potent and Orally Bioavailable Allosteric HIV-1 Integrase Inhibitors
Journal of Medicinal Chemistry·2020· 27 citedOpen Access
Uncialamycin as a novel payload for antibody drug conjugate (ADC) based targeted cancer therapy
Bioorganic & Medicinal Chemistry Letters·2018· 32 cited
Catalytic approach green synthesis, characterization and electrochemical studies of heterocyclic azo dye derived from 5-amino-1,3,4-thiadiazole-2-thiol
Journal of Molecular Liquids·2018· 15 cited
Discovery of Isonicotinamides as Highly Selective, Brain Penetrable, and Orally Active Glycogen Synthase Kinase-3 Inhibitors
Journal of Medicinal Chemistry·2016· 68 citedOpen Access
Discovery of new acylaminopyridines as GSK-3 inhibitors by a structure guided in-depth exploration of chemical space around a pyrrolopyridinone core
Bioorganic & Medicinal Chemistry Letters·2015· 114 citedOpen Access
Homology models of the <scp>HIV</scp>‐1 attachment inhibitor <scp>BMS</scp>‐626529 bound to gp120 suggest a unique mechanism of action
Proteins Structure Function and Bioinformatics·2014· 58 citedOpen Access
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Frequent Co-authors

Robert J. Doerksen(10), David R. Langley(9), E. Manivannan(9), Kevin Kish(8), H.A. Lewis(8), Nicholas A. Meanwell(6), Mark Krystal(6), Sanjeev Gangwar(6), Brian McAuliffe(5), Aihua Xie(5), Gregory D. Vite(5), B. Narasimhulu Naidu(5), Susan Jenkins(5), Chunshan Xie(5), Hong Xiao(4), Carol Krause(4), Catherine R. Burton(4), John E. Macor(4), Gene M. Dubowchik(4), Ira B. Dicker(4)