Guy G. Poirier

Centre hospitalier universitaire de Québec — Canada

Medicine · Health Sciences

97h-index41.2kcitations432works3.22yr avg
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Research Topics

PARP inhibition in cancer therapy(228), DNA Repair Mechanisms(121), Toxin Mechanisms and Immunotoxins(59), Cell death mechanisms and regulation(58), Calcium signaling and nucleotide metabolism(43)

Publications429 total

Nucleoplasmic Lamin A/C controls replication fork restart upon stress by modulating local H3K9me3 and ADP-ribosylation levels
Nature Communications·2025Open Access
Nucleoplasmic Lamin A/C controls replication fork restart upon stress by modulating local H3K9me3 and ADP-ribosylation levels
Universität Zürich, ZORA·2025Open Access
Codon specific readthrough as a mechanism of BRCA2 restoration in acquired PARP inhibitor and chemotherapy resistance
Nucleic Acids Research·2025Open Access
Proteome-wide microarray-based screening of PAR-binding proteins
Nucleic Acids Research·2025· 8 citedOpen Access
CHD6 has poly(ADP-ribose)- and DNA-binding domains and regulates PARP1/2-trapping inhibitor sensitivity via abasic site repair
Nature Communications·2025· 2 citedOpen Access
Nucleoplasmic Lamin A/C controls replication fork restart upon stress by modulating local H3K9me3 and ADP-ribosylation levels
2025· 1 cited
A Kinetic Scout Approach Accelerates Targeted Protein Degrader Development
Angewandte Chemie International Edition·2024· 5 citedOpen Access
A Kinetic Scout Approach Accelerates Targeted Protein Degrader Development
Angewandte Chemie·2024
Proteomic study identifies Aurora-A–mediated regulation of alternative splicing through multiple splicing factors
Journal of Biological Chemistry·2024· 11 citedOpen Access
Une réalité qui se dérobe : l’expérience des altérités dans les oeuvres de Jacques Cartier et de Samuel de Champlain
Les Presses de l'Université de Montréal eBooks·2024
Abstract A019: Inhibition of nicotinamide adenine dinucleotide (NAD) production is a potent therapeutic strategy to inactivate homologous recombination in cancer cells
Molecular Cancer Therapeutics·2024
pADP-ribosylation regulates the cytoplasmic localization, cleavage, and pro-apoptotic function of HuR
Life Science Alliance·2024· 2 citedOpen Access
Poly( <scp>ADP</scp> ‐ribose) mediates bioenergetic defects and redox imbalance in neurons following oxygen and glucose deprivation
The FASEB Journal·2024· 10 citedOpen Access
Tankyrase-1 regulates RBP-mediated mRNA turnover to promote muscle fiber formation
Nucleic Acids Research·2024· 6 citedOpen Access
Bernhardt, Matthieu. La Chine en partage. Les écrits sinophiles du Père Matteo Ricci
Renaissance and Reformation·2023Open Access
ZNF432 stimulates PARylation and inhibits DNA resection to balance PARPi sensitivity and resistance
Nucleic Acids Research·2023· 12 citedOpen Access
pADP-ribosylation Regulates the Cytoplasmic Localization, Cleavage and Pro-apoptotic Function of HuR
2023Open Access
The dynamic process of covalent and non-covalent PARylation in the maintenance of genome integrity: a focus on PARP inhibitors
NAR Cancer·2023· 9 citedOpen Access
Poly(ADP-ribose) mediates bioenergetic defects and redox imbalance in neurons following oxygen and glucose deprivation
2023· 1 citedOpen Access
Supplementary Figure 1 from Failure of Iniparib to Inhibit Poly(ADP-Ribose) Polymerase &lt;i&gt;In Vitro&lt;/i&gt;
2023Open Access
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Frequent Co-authors

Valina L. Dawson(14), Ted M. Dawson(13), Shaida A. Andrabi(7), Scott H. Kaufmann(6), Vishva M. Dixit(6), Serge Desnoyers(5), Michael J. Hendzel(5), William C. Earnshaw(4), Hongmin Wang(4), Yuri Lazebnik(3), Guy S. Salvesen(3), Damien D’Amours(3), Marc F. Poitras(3), Michèle Rouleau(3), No Soo Kim(3), David W. Koh(3), David K. Perry(3), Yusuf A. Hannun(3), Ho Chul Kang(3), Sylvie Bourassa(3)