Jon D. Polishook

Merck & Co., Inc., Rahway, NJ, USA (United States) — United States

Medicine · Health Sciences

31h-index3.8kcitations75works0.02yr avg
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Research Topics

Microbial Natural Products and Biosynthesis(24), Plant Pathogens and Fungal Diseases(16), Mycorrhizal Fungi and Plant Interactions(11), Carbohydrate Chemistry and Synthesis(9), Fungal Biology and Applications(6)

Publications75 total

Nocathiacin, Thiazomycin, and Polar Analogs Are Highly Effective Agents against Toxigenic <i>Clostridioides difficile</i>
Journal of Natural Products·2022· 5 cited
Correction for Zhang et al., Toxin-Mediated Paracellular Transport of Antitoxin Antibodies Facilitates Protection against Clostridium difficile Infection
Infection and Immunity·2015Open Access
Toxin-Mediated Paracellular Transport of Antitoxin Antibodies Facilitates Protection against Clostridium difficile Infection
Infection and Immunity·2014· 44 citedOpen Access
Isolation, structure elucidation and antibacterial activity of a new tetramic acid, ascosetin
The Journal of Antibiotics·2014· 21 citedOpen Access
Kibdelomycin Is a Potent and Selective Agent against Toxigenic Clostridium difficile
Antimicrobial Agents and Chemotherapy·2014· 30 citedOpen Access
Isolation, Structure Elucidation, and Biological Activity of Altersolanol P Using <i>Staphylococcus aureus</i> Fitness Test Based Genome-Wide Screening
Journal of Natural Products·2014· 12 cited
Kibdelomycin A, a congener of kibdelomycin, derivatives and their antibacterial activities
Bioorganic & Medicinal Chemistry Letters·2012· 39 citedOpen Access
Isolation, Structure Elucidation, and Antibacterial Activity of Methiosetin, a Tetramic Acid from a Tropical Sooty Mold (<i>Capnodium</i> sp.)
Journal of Natural Products·2012· 24 cited
Discovery of Kibdelomycin, A Potent New Class of Bacterial Type II Topoisomerase Inhibitor by Chemical-Genetic Profiling in Staphylococcus aureus
Chemistry & Biology·2011· 163 cited
CCDC 793130: Experimental Crystal Structure Determination
The Cambridge Structural Database·2011Open Access
Coelomycin, a highly substituted 2,6-dioxo-pyrazine fungal metabolite antibacterial agent discovered by Staphylococcus aureus fitness test profiling
The Journal of Antibiotics·2010· 21 citedOpen Access
Isolation, Structure, and Coccidiostat Activity of Coccidiostatin A
Journal of Natural Products·2007· 14 cited
Automated Agar Plate Streaker: A Linear Plater on Society for Biomolecular Sciences Standard Plates
SLAS DISCOVERY·2006· 7 citedOpen Access
Isolation and Structures of Novel Fungal Metabolites as Chemokine Receptor (CCR2) Antagonists
The Journal of Antibiotics·2005· 28 citedOpen Access
New fungal metabolite geranylgeranyltransferase inhibitors with antifungal activity
Natural Product Research·2005· 14 cited
Discovery of structurally diverse natural product antagonists of chemokine receptor CXCR3
Molecular Diversity·2005· 50 cited
Identification of Diverse Microbial Metabolites as Potent Inhibitors of HIV-1 Tat Transactivation
Chemistry & Biodiversity·2005· 39 cited
Aspercyclide A—C, Three Novel Fungal Metabolites from Aspergillus sp. as Inhibitors of High‐Affinity IgE Receptor.
ChemInform·2004
Aspercyclide A–C, three novel fungal metabolites from Aspergillus sp. as inhibitors of high-affinity IgE receptor
Tetrahedron Letters·2004· 26 cited
Isolation, Structure and HIV‐1 Integrase Inhibitory Activity of Exophillic Acid, a Novel Fungal Metabolite from Exophiala pisciphila.
ChemInform·2004
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Frequent Co-authors

Sheo B. Singh(28), Gerald F. Bills(22), Deborah L. Zink(22), Anne W. Dombrowski(21), Michael Goetz(13), Fernando Peláez(11), John G. Ondeyka(9), Hiranthi Jayasuriya(9), Daria J. Hazuda(8), Ziqiang Guan(7), Peter J. Felock(7), Russell B. Lingham(7), Kithsiri Herath(6), John W. Phillips(5), Francisca Vicente(5), Robert G. K. Donald(5), Keith C. Silverman(5), Gonzalo Platas(4), John Allocco(3), Scott K. Smith(3)