Wei‐Hua Chiu

Philipps University of Marburg — Germany

Medicine · Health Sciences

12h-index442citations25works4.02yr avg
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Research Topics

Parkinson's Disease Mechanisms and Treatments(15), Neurological disorders and treatments(13), Nerve injury and regeneration(6), Neuroscience and Neuropharmacology Research(5), Neural dynamics and brain function(3)

Publications25 total

Ion channel dysregulation and cellular adaptations to alpha-synuclein in stressful pacemakers of the parkinsonian brainstem
Pharmacology & Therapeutics·2024· 7 cited
Enhanced firing of locus coeruleus neurons and SK channel dysfunction are conserved in distinct models of prodromal Parkinson's disease
2024· 1 citedOpen Access
Disentangling dyskinesia from parkinsonism in motor structures of patients with schizophrenia
Brain Communications·2022· 14 citedOpen Access
Enhanced firing of locus coeruleus neurons and SK channel dysfunction are conserved in distinct models of prodromal Parkinson’s disease
Scientific Reports·2022· 18 citedOpen Access
α-Synuclein–induced Kv4 channelopathy in mouse vagal motoneurons drives nonmotor parkinsonian symptoms
Science Advances·2021· 18 citedOpen Access
Radical-mediated aerobic oxidation of substituted styrenes and stilbenes
New Journal of Chemistry·2021
JN403, an alpha-7-nicotine-acetylcholine-receptor agonist, reduces alpha-synuclein induced inflammatory parameters of <i>in vitro</i> microglia but fails to attenuate the reduction of TH positive nigral neurons in a focal alpha-synuclein overexpression mouse model of Parkinson’s disease
2020
Vagal motoneurons in Parkinson's disease
Elsevier eBooks·2020· 1 cited
Contributors
Elsevier eBooks·2020
α-Synuclein-induced Kv4 channelopathy in mouse vagal motoneurons causes non-motor parkinsonian symptoms
2019Open Access
α-Synuclein 2.0 — Moving towards Cell Type Specific Pathophysiology
Neuroscience·2019· 17 cited
Activity Patterns in the Neuropil of Striatal Cholinergic Interneurons in Freely Moving Mice Represent Their Collective Spiking Dynamics
eNeuro·2019· 33 citedOpen Access
Wave-like activity patterns in the neuropil of striatal cholinergic interneurons in freely moving mice represent their collective spiking dynamics
2018· 6 citedOpen Access
A53T-α-synuclein overexpression in murine locus coeruleus induces Parkinson’s disease-like pathology in neurons and glia
Acta Neuropathologica Communications·2018· 66 citedOpen Access
Selective remodeling of glutamatergic transmission to striatal cholinergic interneurons after dopamine depletion
European Journal of Neuroscience·2017· 33 citedOpen Access
Protective efficacy of phosphodiesterase-1 inhibition against alpha-synuclein toxicity revealed by compound screening in LUHMES cells
Scientific Reports·2017· 69 citedOpen Access
Targeted overexpression of A53T-alpha-synuclein induces progressive neurodegeneration and electrophysiological changes of noradrenergic locus coeruleus neurons – A preclinical model of Parkinson's disease
Basal Ganglia·2017
Mutant α-Synuclein Overexpression Induces Stressless Pacemaking in Vagal Motoneurons at Risk in Parkinson's Disease
Journal of Neuroscience·2017Open Access
Mutant α-Synuclein Overexpression Induces Stressless Pacemaking in Vagal Motoneurons at Risk in Parkinson's Disease
Journal of Neuroscience·2016· 33 cited
l-DOPA-induced dyskinesia is associated with a deficient numerical downregulation of striatal tyrosine hydroxylase mRNA-expressing neurons
Neuroscience·2016· 8 cited
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Frequent Co-authors

Joshua A. Goldberg(11), Wolfgang H. Oertel(10), Günter U. Höglinger(7), James B. Koprich(7), Bolam Lee(5), Jonathan M. Brotchie(5), Jochen Roeper(5), Martin T. Henrich(4), Fanni F. Geibl(4), Lina A. Matschke(4), Candan Depboylu(4), Vincent Ries(4), Thomas Carlsson(4), Ruth E. Musgrove(4), Niels Decher(3), Lior Tiroshi(3), José de Jesús Aceves Buendía(3), Wolfgang H. Oertel(2), Lars Timmermann(2), Guido Hermanns(2)