Andrea Contestabile

Italian Institute of Technology — Italy

Neuroscience · Life Sciences

34h-index3.7kcitations101works7.32yr avg
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Research Topics

Neuroscience and Neuropharmacology Research(19), Down syndrome and intellectual disability research(18), Genetics and Neurodevelopmental Disorders(15), Neurogenesis and neuroplasticity mechanisms(12), Neuroscience and Neural Engineering(12)

Publications100 total

Efficacy of bumetanide for cognitive improvement in children and adolescents with Down syndrome: study protocol of a randomised, double-blind, placebo-controlled trial
BMJ Open·2026Open Access
Shuffling of HVRs in AAV Capsid Reveals a Context-Dependent Role for HVR5 in Peripheral Tissue Detargeting While Ensuring CNS Targeting
SSRN Electronic Journal·2025Open Access
Integrative multi-omic analysis reveals conserved cell-projection deficits in human Down syndrome brains
Neuron·2024· 22 cited
Heterogeneous subpopulations of GABAAR-responding neurons coexist across neuronal network scales and developmental stages in health and disease
iScience·2024· 7 citedOpen Access
EARLY-IN-LIFE INTERVENTIONS TARGETING NKCC1 RESCUE THE ALTERED GABAERGIC SIGNALING AND THE EPILEPTIC AND LOCOMOTOR DEFICITS IN THE ADULT DS MICE
IBRO Neuroscience Reports·2023Open Access
Heterogeneous subpopulations of GABAAR-responding neurons coexist in physiological and pathological mature neuronal networks at increasing scales of complexity
2023Open Access
LSD1/PRMT6-targeting gene therapy to attenuate androgen receptor toxic gain-of-function ameliorates spinobulbar muscular atrophy phenotypes in flies and mice
Nature Communications·2023· 25 citedOpen Access
Design, Synthesis, <i>In Vitro</i> and <i>In Vivo</i> Characterization of Selective NKCC1 Inhibitors for the Treatment of Core Symptoms in Down Syndrome
Journal of Medicinal Chemistry·2021· 20 citedOpen Access
Restoring neuronal chloride homeostasis with anti-NKCC1 gene therapy rescues cognitive deficits in a mouse model of Down syndrome
Molecular Therapy·2021· 31 citedOpen Access
Rescuing Over-activated Microglia Restores Cognitive Performance in Juvenile Animals of the Dp(16) Mouse Model of Down Syndrome
Neuron·2020· 137 citedOpen Access
Discovery of a Small Molecule Drug Candidate for Selective NKCC1 Inhibition in Brain Disorders
Chem·2020· 60 citedOpen Access
Gene Editing Preserves Visual Functions in a Mouse Model of Retinal Degeneration
Frontiers in Neuroscience·2019· 37 citedOpen Access
SINEUP Non-coding RNA Targeting GDNF Rescues Motor Deficits and Neurodegeneration in a Mouse Model of Parkinson’s Disease
Molecular Therapy·2019· 66 citedOpen Access
Synapsin I Synchronizes GABA Release in Distinct Interneuron Subpopulations
Cerebral Cortex·2019· 16 citedOpen Access
Gene editing preserves visual function in a mouse model of retinal degeneration
2019· 1 citedOpen Access
A light-gated potassium channel for sustained neuronal inhibition
Nature Methods·2018· 61 citedOpen Access
Translating molecular advances in Down syndrome and Fragile X syndrome into therapies
European Neuropsychopharmacology·2018· 14 cited
Synapsin I and Synapsin II regulate neurogenesis in the dentate gyrus of adult mice
Oncotarget·2018· 29 citedOpen Access
Mechano-sensitization of mammalian neuronal networks through expression of the bacterial large-conductance mechanosensitive ion channel
Journal of Cell Science·2018· 45 citedOpen Access
Influence of topography of nanofibrous scaffolds on functionality of engineered neural tissue
Journal of Materials Chemistry B·2018· 30 citedOpen Access
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Frequent Co-authors

Elisabetta Ciani(11), Laura Cancedda(10), Renata Bartesaghi(7), Fabio Benfenati(6), Tatiana Fila(5), Pietro Baldelli(5), Antonio Contestabile(5), Martina Parrini(4), Laura Gasparini(4), Diego Ghezzi(3), Annalisa Savardi(3), Gabriele Lignani(3), Flavia Valtorta(3), Marina Nanni(3), Giuseppe Ronzitti(3), Maria Pennuto(3), Anna Rocchi(3), Marco Virgili(3), Gabriele Deidda(2), Shovan Naskar(2)