Mark D. Szczelkun

University of Exeter — United Kingdom

Biochemistry, Genetics and Molecular Biology · Life Sciences

32h-index3.1kcitations106works9.32yr avg
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Research Topics

DNA and Nucleic Acid Chemistry(44), Advanced biosensing and bioanalysis techniques(34), Bacterial Genetics and Biotechnology(30), DNA Repair Mechanisms(30), CRISPR and Genetic Engineering(29)

Publications106 total

Individual <i>Staphylococcus aureus</i> SauUSI restriction endonuclease motors fragment methylated DNA
2025Open Access
Structure and activation mechanism of a Lamassu phage and plasmid defense system
Nature Structural & Molecular Biology·2025· 2 citedOpen Access
Eco-evolutionary feedbacks drive the co-occurrence of restriction-modification systems and antimicrobial resistance genes
2025Open Access
Defence systems drive accessory genome interactions in <i>Pseudomonas aeruginosa</i>
2025Open Access
Structure and Activation Mechanism of a Lamassu Phage Defence System
2025· 7 citedOpen Access
Various plasmid strategies limit the effect of bacterial restriction–modification systems against conjugation
Nucleic Acids Research·2024· 27 citedOpen Access
The bacterial defense system MADS interacts with CRISPR-Cas to limit phage infection and escape
Cell Host & Microbe·2024· 25 citedOpen Access
Various plasmid strategies limit the effect of bacterial Restriction-Modification systems against conjugation
2024· 3 citedOpen Access
Multi-layered genome defences in bacteria
Current Opinion in Microbiology·2024· 27 citedOpen Access
Short-range translocation by a restriction enzyme motor triggers diffusion along DNA
Nature Chemical Biology·2024· 2 citedOpen Access
Short-range DNA translocation initiates long-range 1-dimensional DNA diffusion by the Type III restriction enzyme EcoP15I
2023Open Access
CRISPR–Cas12a-mediated DNA clamping triggers target-strand cleavage
Nature Chemical Biology·2022· 57 citedOpen Access
Ultrafast twist measurements resolve short range dsDNA translocation during ATP-driven initiation of DNA sliding by EcoP15I
Biophysical Journal·2022
Bacteriostatic antibiotics promote CRISPR-Cas adaptive immunity by enabling increased spacer acquisition
Cell Host & Microbe·2021· 63 citedOpen Access
ENDO-Pore: high-throughput linked-end mapping of single DNA cleavage events using nanopore sequencing
Nucleic Acids Research·2021· 7 citedOpen Access
ENDO-Pore: High-throughput linked-end mapping of single DNA cleavage events using nanopore sequencing
2021· 2 citedOpen Access
A gate and clamp regulate sequential DNA strand cleavage by CRISPR-Cas12a
2021· 4 citedOpen Access
Bacteriostatic antibiotics promote the evolution of CRISPR-Cas immunity
2021· 2 citedOpen Access
Evolutionary Ecology and Interplay of Prokaryotic Innate and Adaptive Immune Systems
Current Biology·2020· 97 citedOpen Access
Mitochondrial import, health and mtDNA copy number variability seen when using type II and type V CRISPR effectors
Journal of Cell Science·2020· 34 citedOpen Access
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Frequent Co-authors

Ralf Seidel(9), Stephen E. Halford(9), Kara van Aelst(7), Edze R. Westra(5), Fiona M. Diffin(5), Massimo Antognozzi(5), Pavel Janščák(4), M. J. Miles(4), Tatiana Dimitriu(3), Julia I. Toth(3), Keith Firman(3), Cees Dekker(3), Luke J. Peakman(3), Nigel J. Savery(3), Giedrius Gasiūnas(2), Tautvydas Karvelis(2), Virginijus Šikšnys(2), Thomas A. Bickle(2), Friedrich W. Schwarz(2), Joost GP Bloom(2)