Yugang Guo

Zhejiang University — China

Medicine · Health Sciences

16h-index2.1kcitations53works26.62yr avg
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Research Topics

CAR-T cell therapy research(15), Immunotherapy and Immune Responses(10), Cancer-related molecular mechanisms research(8), Immune Cell Function and Interaction(7), RNA modifications and cancer(7)

Publications53 total

IL-10-expressing, anti-CD19 CAR T cells for patients with relapsed or refractory B-cell acute lymphoblastic leukaemia: an open-label, single-arm, phase 1 study
The Lancet Haematology·2025· 1 citedOpen Access
Metabolic reinvigoration of NK cells by IL-21 enhances immunotherapy against MHC-I deficient solid tumors
2025Open Access
Computational-aided rational mutation design of pertuzumab to overcome active HER2 mutation S310F through antibody–drug conjugates
Proceedings of the National Academy of Sciences·2024· 2 citedOpen Access
Clinical Efficacy and Complications of Spinal Surgery Unilateral Biportal Endoscopy for Cervical Spondylosis: A Systematic Review and Meta-Analysis
World Neurosurgery·2024· 5 cited
An Oral PROTAC Targeting HPK1 Degradation Potentiates Anti‐Solid Tumor Immunity
Advanced Materials·2024· 12 cited
1‰ Regular Dose of Metabolically Armored CD19 CAR-T Cells Induces Robust <i>in vivo</i> Expansion and Complete Remission in Relapsed or Refractory Diffuse Large B-Cell Lymphoma Patients
Blood·2024
IL-10 Expressing CD19 CAR-T Cells Induce Complete Remission and Improve Long-Term Protection in Relapsed or Refractory B-Cell Hematological Malignancies
Blood·2024· 9 cited
The type 2 cytokine Fc–IL-4 revitalizes exhausted CD8+ T cells against cancer
Nature·2024· 99 citedOpen Access
CT-244 Updated Clinical Progress of IL-10 expressing CD19 CAR-T Cells for Treatment of Relapsed or Refractory B-Cell Hematological Malignancies at Tiny Doses
Clinical Lymphoma Myeloma & Leukemia·2024
Updated Clinical Progress of IL-10 expressing CD19 CAR-T Cells for Treatment of Relapsed or Refractory B-Cell Hematological Malignancies at Tiny Doses
Clinical Lymphoma Myeloma & Leukemia·2024
Updated Clinical Progress of IL-10-Expressing CD19 CAR-T Cells for Treatment of Relapsed or Refractory B-Cell Hematological Malignancies at Tiny Doses
Clinical Lymphoma Myeloma & Leukemia·2024
Grooved Microneedle Patch Augments Adoptive T Cell Therapy Against Solid Tumors via Diverting Regulatory T Cells
Advanced Materials·2024· 28 cited
Abstract LB236: Metabolically armed CD19 CAR-T cells for safe and effective treatment of relapsed or refractory CD19+ B cell hematological malignancies at extremely low doses
Cancer Research·2024· 1 cited
IL-10-expressing CAR T cells resist dysfunction and mediate durable clearance of solid tumors and metastases
Nature Biotechnology·2024· 215 citedOpen Access
The role of APOBEC3C in modulating the tumor microenvironment and stemness properties of glioma: evidence from pancancer analysis
Frontiers in Immunology·2023· 8 citedOpen Access
Comprehensive Analysis of RNA-Binding Protein-Related lncRNA in Breast Invasive Carcinoma
Frontiers in Bioscience-Landmark·2023· 3 citedOpen Access
A pan-cancer landscape of IGF2BPs and their association with prognosis, stemness and tumor immune microenvironment
Frontiers in Oncology·2023· 51 citedOpen Access
Cancer-cell stiffening via cholesterol depletion enhances adoptive T-cell immunotherapy
Nature Biomedical Engineering·2021· 231 citedOpen Access
A Pan-Cancer Landscape of HOX-Related lncRNAs and Their Association With Prognosis and Tumor Microenvironment
Frontiers in Molecular Biosciences·2021· 14 citedOpen Access
Switchable immune modulator for tumor-specific activation of anticancer immunity
Science Advances·2021· 41 citedOpen Access
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Frequent Co-authors

Weihua Xiao(10), Li Tang(10), Yuqing Xie(6), Min Gao(6), Yongjun Zhong(6), Jie Sun(6), Qian Ding(5), Qian Xu(5), Zhigang Tian(5), Xiaoping Song(5), Changsheng Shao(5), Qianwen Xu(5), Lei Xue(5), Jingjing Ren(5), Xingbing Wang(5), Guohui Ma(4), Wenyao Kang(4), Hao Jia(4), Xuhan Zhang(4), Chonglin Liu(4)