Torsten Steinmetzer

Philipps University of Marburg — Germany

Medicine · Health Sciences

36h-index5.0kcitations181works3.52yr avg
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Research Topics

Peptidase Inhibition and Analysis(29), Protease and Inhibitor Mechanisms(26), Blood Coagulation and Thrombosis Mechanisms(26), Influenza Virus Research Studies(17), Chemical Synthesis and Analysis(17)

Publications181 total

Design, Synthesis, and Characterization of Dichlorobiphenyl-Derived Inhibitors of the Proprotein Convertase Furin
Journal of Medicinal Chemistry·2025· 1 citedOpen Access
Furin sustains tumor-promoting signals in KRAS- and BRAF-mutated colorectal cancer by engaging the TGF-β1–COX-2 axis in a reciprocal regulatory network
2025Open Access
Membrane disruption attenuates agonist potency in prostanoid receptors
Biochemical Journal·2025Open Access
Proteolytic processing of the Marburg virus glycoprotein depends on Sec61β and is required for cell entry
2025Open Access
Immunogenicity of NSDV GP38 and the role of furin in GP38 proteolytic processing
Journal of Virology·2025Open Access
Repurposing of Furin Inhibitors to Reduce Pathogenic E. coli- and Shigella flexneri-Induced Cytotoxicity, Oxidative Stress and Inflammation in Mammalian Epithelial Cells
Antibiotics·2025Open Access
Unveiling the Role of TMPRSS2 in the Proteolytic Activation of Pandemic and Zoonotic Influenza Viruses and Coronaviruses in Human Airway Cells
Viruses·2024· 3 citedOpen Access
In Vitro Evaluation of Antipseudomonal Activity and Safety Profile of Peptidomimetic Furin Inhibitors
Biomedicines·2024· 3 citedOpen Access
A molecular mechanism to diversify Ca2+ signaling downstream of Gs protein-coupled receptors
Nature Communications·2024· 21 citedOpen Access
Macrocyclic Inhibitors Targeting the Prime Site of the Fibrinolytic Serine Protease Plasmin
ChemMedChem·2024· 1 citedOpen Access
PK/PD investigation of antiviral host matriptase/TMPRSS2 inhibitors in cell models
Scientific Reports·2024· 4 citedOpen Access
Novel proteolytic activation of Ebolavirus glycoprotein GP by TMPRSS2 and cathepsin L at an uncharted position can compensate for furin cleavage
Virus Research·2024· 5 citedOpen Access
Synthesis and structural characterization of new macrocyclic inhibitors of the Zika virus NS2B–NS3 protease
Archiv der Pharmazie·2024· 6 citedOpen Access
Front Cover: Fragment‐Based Design, Synthesis, and Characterization of Aminoisoindole‐Derived Furin Inhibitors (ChemMedChem 9/2024)
ChemMedChem·2024Open Access
Antiviral Drug Candidate Repositioning for Streptococcus suis Infection in Non-Tumorigenic Cell Models
Biomedicines·2024· 1 citedOpen Access
ACE2 acts as a novel regulator of TMPRSS2-catalyzed proteolytic activation of influenza A virus in airway cells
Journal of Virology·2024· 10 citedOpen Access
Fragment‐Based Design, Synthesis, and Characterization of Aminoisoindole‐Derived Furin Inhibitors
ChemMedChem·2024· 5 citedOpen Access
In vitro testing of host-targeting small molecule antiviral matriptase/TMPRSS2 inhibitors in 2D and 3D cell-based assays
Biomedicine & Pharmacotherapy·2023· 6 citedOpen Access
Front Cover: Synthesis and Structural Characterization of Macrocyclic Plasmin Inhibitors (ChemMedChem 6/2023)
ChemMedChem·2023Open Access
In Vitro Pharmacokinetic Behavior of Antiviral 3-Amidinophenylalanine Derivatives in Rat, Dog and Monkey Hepatocytes
Biomedicines·2023· 1 citedOpen Access
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Frequent Co-authors

Kornelia Hardes(13), Wolfgang Garten(13), Eva Böttcher‐Friebertshäuser(12), Manuel E. Than(10), Frank Sielaff(8), Jörg Stürzebecher(8), Sven O. Dahms(7), Hans‐Dieter Klenk(6), Andrea Schweinitz(6), Iris Lindberg(6), Yinghui Lu(6), Maya Hammami(5), Anne Stürzebecher(5), Gero L. Becker(5), A. Heine(5), G. Klebe(5), Daniela Meyer(4), O. Schuster(4), Miriam Ruth Heindl(3), Thuy Van Lam van(3)